Omez Insta powder for oral suspension 20mg 30 sachets — Made in India — Free Delivery
(Omez Insta )
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Description Omez Insta powder for oral suspension 20mg 30 sachets — Made in India — Free Delivery
Pharmacological properties
Antisecretory, antiulcer agent, inhibitor of n + / k + -atphase (proton pump). inhibits the final phase of secretion of hydrochloric acid in parietal cells, inhibits both basal and pentagastrin-stimulated secretion. due to a significant and prolonged decrease in the acidity of gastric juice, it contributes to the rapid healing of the ulcer.
After administration, the preparation is rapidly and completely absorbed, about 90–95% of the preparation binds to blood plasma proteins. The bioavailability of a single oral dose is about 40%. Concomitant food intake does not affect the bioavailability of the preparation. Cmax in blood plasma is achieved within 0.5-1.5 hours after administration. The effect lasts for 24 hours or more. T½ is about 1 hour. The total clearance of the preparation in the body is 500-600 mg / min. Excreted by the kidneys as metabolites.
Indications
Treatment of heartburn caused by increased acidity of gastric juice (hyperacidity).
Application
Inside for 1 hour before meals. Dissolve the contents of the sachet in 30 ml of water. the preparation should not be mixed with other liquids or food. the suspension is stirred and drunk immediately after preparation. water is added to an empty glass with the rest of the suspension and the rest of the preparation is drunk.
The recommended dose for adults and children over the age of 12 is 1 sachet once a day. If you are resistant to treatment and have frequent heartburn, you should consult your doctor.
Contraindications
Hypersensitivity to omeprazole and / or to other components of the preparation; children under the age of 12; lactation period; hereditary galactose intolerance, lactase deficiency or glucose and galactose malabsorption syndrome, metabolic alkalosis.
Side effects
Criteria for assessing the incidence of adverse preparation reactions: often - ≥1 / 100; infrequently - ≥1 / 1000 - 1/100; rarely - 1/1000.
From the digestive system: often - diarrhea, constipation, abdominal pain, nausea, vomiting, flatulence, rarely - dry mouth, stomatitis, gastrointestinal candidiasis, lack of appetite.
From the nervous system: often - headache; rarely - dizziness, loss of consciousness, general weakness, insomnia, drowsiness, anxiety, paresthesia; rarely - agitation, reversible confusion, aggressiveness, depression, hallucinations.
Skin disorders: infrequently - rash (including bullous) and / or itching, dermatitis, urticaria, rarely - photosensitivity, exudative erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, alopecia.
Allergic reactions: rarely - angioedema, fever, bronchospasm, anaphylactic shock.
From the side of the cardiovascular system: chest pain or angina pectoris, tachycardia, bradycardia, palpitations, increased blood pressure, peripheral edema.
From the hepatobiliary system: infrequently - taste disturbance, increased activity of liver enzymes, rarely - in patients with previous severe liver disease, hepatitis (including jaundice), encephalopathy, severe liver dysfunction (including liver failure).
From the musculoskeletal system: rarely - arthralgia, muscle weakness, myalgia.
Others: infrequently - malaise, rarely - interstitial nephritis, gynecomastia, visual impairment, peripheral edema, increased sweating, impotence, hyponatremia.
Special instructions
When prescribing the preparation omez insta for patients with stomach ulcers, it is necessary to exclude the possibility of a malignant disease, since omez insta can mask its symptoms and delay the determination of an accurate diagnosis.
For elderly people and patients with impaired renal function when using Omez Insta, dose adjustment is not required.
During treatment, it is possible to distort the results of laboratory tests of liver function and indicators of the concentration of gastrin in the blood plasma.
Decreased gastric acid secretion by proton pump inhibitors or other inhibitory agents leads to the growth of normal intestinal microflora, which, in turn, may lead to a slight increase in the risk of intestinal infections.
With long-term use of proton pump inhibitors, cases of moderate vitamin B12 deficiency have been reported, therefore, in some cases, it may be advisable to monitor the level of vitamin B12 in the blood plasma.
The preparation contains sodium bicarbonate, which should be taken into account when used in patients who adhere to a sodium-restricted diet. Sodium bicarbonate is contraindicated in patients with metabolic alkalosis.
Use during pregnancy and lactation. The preparation is not used during pregnancy.
During the use of the preparation, breastfeeding should be discontinued.
Children. Do not use in children under 12 years of age.
Influence on the ability to drive vehicles or when working with mechanisms. In general, it does not affect, but the possibility of the appearance of such adverse reactions as dizziness and drowsiness should be taken into account.
Interactions
The absorption of certain medicinal substances can be affected by decreased gastric acidity. as with the use of other acid secretion inhibitors or antacids, treatment with omeprazole decreases the absorption of ketoconazole and itraconazole. auc and cmax of itraconazole significantly decreased to 60% when used simultaneously with omeprazole.
Interactions with antacids with simultaneous use have not been noted. Also, no food interactions were noted.
Omeprazole can cause a delay in the elimination of diazepam, warfarin and preparations that are extensively metabolized by oxidation in the liver (cytochrome P450). Although the concentration of phenytoin in the study with the use of omeprazole at a dose of 20 mg / day was unchanged, it is recommended to control the level of phenytoin, as well as oral anticoagulants and, if necessary, reduce the dosage.
Concomitant treatment does not affect the coagulation time with continuous administration of warfarin. However, in the case of the simultaneous use of omeprazole and clarithromycin, an increase in their concentration in the blood plasma is detected.
Omeprazole can reduce the absorption of ketoconazole, ampicillin, iron preparations. Interactions with metronidazole or amoxicillin have not been reported.
The results of studies of various interactions between omeprazole and other preparations have shown that omeprazole in doses of 20-40 mg does not affect the relevant isoforms of cytochrome P450. Omeprazole does not interact with CYP 1A2 (caffeine, phenacetin, theophylline), CYP 2C9 (S-warfarin, piroxicam, diclofenac, naproxen), CYP 2D6 (metoprolol, propranolol), CYP 2E1 (ethanol), CYP 3A (cyclosporine, lidocadin , estradiol, erythromycin, budenoside).
Medicines that suppress the enzymes CYP 2C19 and CYP 3A (HIV protease inhibitors, ketoconazole, itraconazole) can increase the concentration of omeprazole in the blood plasma.
Proton pump inhibitors, including omeprazole, should not be used with atazanavir.
The simultaneous use of omeprazole with tacrolimus can lead to an increase in the concentration of tacrolimus in the blood plasma. At the beginning or after treatment with omeprazole, it is recommended to monitor the concentration of tacrolimus in the blood plasma.
No interactions were noted between omeprazole, theophylline, caffeine, quinidine, lidocaine, propranolol, and ethanol.
Overdose
In case of an overdose of the preparation omez insta, symptoms occur that are characteristic of side effects. there is no specific antidote. omeprazole binds to blood plasma proteins, as a result, poorly excreted during dialysis. in case of an overdose, measures are taken to remove the unabsorbed preparation into the gastrointestinal tract, symptomatic and supportive treatment is carried out.
Storage conditions
At a temperature not exceeding 25 ° c.
Tags: Omez
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