Pompezo lyophilisate for solution for injection 40mg 1 pc — Made in Turkey — Free Delivery
(Pompezo)
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Description Pompezo lyophilisate for solution for injection 40mg 1 pc — Made in Turkey — Free Delivery
Product description
Lyophilisate for Pompezo solution for injection is used for the indications below.
Adults:
- antisecretory therapy in cases where it is impossible to use the oral route of administration, for example:
- gastroesophageal reflux disease in patients with esophagitis and / or severe reflux symptoms;
- treatment of stomach ulcers associated with therapy with non-steroidal anti-inflammatory preparations(NSAIDs);
- prevention of gastric and duodenal ulcers associated with NSAID therapy in patients at risk;
- short-term maintenance of hemostasis and prevention of rebleeding in patients after endoscopic treatment of acute bleeding of gastric or duodenal ulcers.
- Children and adolescents aged 1 to 18 years: antisecretory therapy in cases where it is impossible to use the oral route of administration, for example, gastroesophageal reflux disease (GERD) in patients with erosive reflux esophagitis and / or severe reflux symptoms.
Compound
Active substance: esomeprazole;
1 bottle contains esomeprazole (in the form of esomeprazole sodium) 40 mg;
Excipients: sodium edetate, sodium hydroxide.
Contraindications
Hypersensitivity to the active substance, to other substituted benzimidazole or other components of the preparation.
Simultaneous use with atazanavir, nelfinavir.
Mode of application
The reconstituted solution should be visually inspected for particles and discoloration prior to use. Only clear solution should be used. The solution is intended for single use only.
If the entire contents of the vial are not needed, the unused solution should be disposed of in accordance with local requirements.
Application features
Pregnant
Esomeprazole should be used with caution in pregnant women.
Children
Applied to children aged 1 year and older as a means for antisecretory therapy in the case when oral administration of the preparation is not possible.
Drivers
Esomeprazole sodium is unlikely to affect the ability to drive and operate machinery. During treatment, adverse reactions from the nervous system or organs of vision may occur.
Overdose
The experience of deliberate overdose is currently very limited. Symptoms that resulted from the 280 mg oral dose were gastrointestinal symptoms and weakness. A single oral dose of 80 mg of esomeprazole and an intravenous administration of 308 mg of esomeprazole over 24 hours did not cause any consequences. The specific antidote is unknown. Esomeprazole binds significantly to blood plasma proteins and is therefore poorly eliminated by dialysis. As with any overdose, symptomatic treatment and general supportive measures should be taken.
Side effects
General disorders and reactions at the injection site: malaise, increased sweating.
Irreversible visual impairment was observed in isolated cases in critically ill patients who received omeprazole as an intravenous injection, especially in high doses, but a causal relationship has not been established.
Interaction
Esomeprazole is metabolized by CYP2C19 and CYP3A4. Concomitant oral administration of esomeprazole and the CYP3A4 inhibitor clarithromycin (500 mg twice daily) resulted in a doubling of the exposure (AUC) of esomeprazole. The simultaneous use of esomeprazole and a combined inhibitor of CYP2C19 and CYP3A4 can lead to an increase in the exposure of esomeprazole by more than two times. The CYP2C19 and CYP3A4 inhibitor voriconazole increased the AUC of omeprazole by 280%. Dose adjustments for esomeprazole are not always necessary in these situations. However, it may be necessary for patients with severely impaired liver function and in cases where long-term treatment is indicated.
Preparations that can stimulate CYP2C19 or CYP3A4 or both of these enzymes (such as rifampicin and St. John's wort) can reduce the plasma concentration of esomeprazole by increasing its metabolism.
Storage conditions
Store at a temperature not exceeding 25 ° C, protected from light and out of reach of children.
Shelf life is 3 years.
Tags: Pompezo
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