Rynomistyn nasal drops solution 0.05% / 0.01%, 10 ml — Made in Ukraine — Free Delivery

Pharmacodynamics. Xylometazoline is an α-adrenergic agonist for topical use, an imidazoline derivative. causes a narrowing of the blood vessels of the mucous membrane of the nasal cavity, eliminates its hyperemia and edema, reduces exudation. the effect of xylometazoline develops in 10-15 minutes, the effect lasts 5-6 hours, vasoconstriction persists for another 8-12 hours.

Miramistin is an antiseptic of a group of cationic surfactants - detergents. The mechanism of action of miramistin is based on a direct hydrophobic interaction with the lipids of the membranes of microorganisms, as a result of which the membrane is loosened, its permeability for high-molecular substances increases, the activity of the enzyme systems of the microbial cell is disrupted, which leads to inhibition of the vital activity of microorganisms and their cytolysis. Unlike other antiseptics, miramistin has a high selectivity of action against microorganisms, practically not acting on the membranes of human cells. This is due to a different structure of cell membranes in humans: a significantly longer length of lipid radicals, which sharply limits the possibility of hydrophobic interaction of miramistin with cells.

Miramistin is active against gram-positive and gram-negative, aerobic and anaerobic, spore-forming and asporogenic bacteria in the form of monocultures and microbial associations, including hospital strains with multi-resistance to antibiotics.

It is more effective against gram-positive bacteria (staphylococcus, streptococcus, etc.), has a detrimental effect on sexually transmitted diseases (gonococcus, treponema pallidum, Trichomonas, chlamydia), as well as influenza, herpes, human immunodeficiency viruses and others. Has antifungal effect (on ascomycetes, dermatophytes, yeast, yeast-like and other pathogenic fungi). Under the influence of miramistin, the resistance of microorganisms to antibiotics decreases. Miramistin has an anti-inflammatory and immunoadjuvant effect, enhances local defense reactions, accelerates regeneration processes, activates nonspecific defense mechanisms due to modulation of the cellular and local humoral immune response. Rynomistyn ® has a balanced pH value characteristic of the nasal cavity. Due to the optimal composition of the components, the drops do not cause dryness and irritation of the mucous membrane, facilitate the outflow of mucus and do not suppress the activity of the cilia of the epithelium of the nasal passages.

Pharmacokinetics. When applied to the mucous membrane, xylometazoline causes a local narrowing of blood vessels and is practically not absorbed into the bloodstream, without exerting a systemic effect. There are no data on the possibility of penetration of miramistin into the systemic circulation.

Acute and chronic forms of rhinitis, sinusitis, rhinosinusitis, which are accompanied by nasal congestion and complicated by microbial infection; complex therapy of acute otitis media and eustachitis (in order to restore the patency of the Eustachian tube); prevention of infectious complications during rhinoscopy and other manipulations in the area of ​​the nasopharynx.

Before administration of the preparation, thoroughly cleanse the nasal cavity.

Rynomistyn®, nasal drops 0.05% / 0.01%, is used in children aged 1 to 11 years.