Solex 100mg 30 tablets — Made in Switzerland — Free Delivery

(Solex )
Solex 100mg 30 tablets — Made in Switzerland — Free Delivery
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Rivopharm SA Brand: Rivopharm SA
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Description Solex 100mg 30 tablets — Made in Switzerland — Free Delivery

Product description 

Solex tablets are used to treat schizophrenia.

Compound

The active substance is amisulpride (one tablet contains amisulpride 100 mg).
Excipients: lactose, monohydrate; cellulose microcrystalline; methylcellulose; sodium starch glycolate (type A); magnesium stearate.

Contraindications

  • hypersensitivity to the active substance or other components of the preparation;
  • it is advisable to refrain from prescribing this preparation to patients with diagnosed or suspected pheochromocytoma who have taken antidopaminergic preparations, including some benzamides;
  • detected or suspected prolactin-dependent tumors, such as prolactin-secreting pituitary adenoma and breast cancer;
  • use in combination with levodopa;
  • combination with preparations that may cause torsades de pointes.

Mode of application

If the daily dose does not exceed 400 mg, the preparation should be taken once a day.
A dose greater than 400 mg should be divided into 2 doses.
Acute psychotic episodes
You can start treatment with intramuscular injection, which will last several days, at a maximum dose of 400 mg / day, followed by a transition to oral administration.
Doses of 400 mg/day to 800 mg/day are recommended for oral administration. The maximum oral dose should not exceed 1200 mg/day. The safety of doses greater than 1200 mg/day has not been extensively studied. In this regard, such doses should not be used.
The maintenance dose or dose adjustments should be set individually, according to the patient's response.
In all cases, maintenance therapy should be prescribed individually, at the level of the minimum effective dose.
Mostly negative episodes
Recommended doses are from 50 mg/day to 300 mg/day. Doses must be selected individually. The optimal dose is about 100 mg/day.

Application features

pregnant
Amisulpride has not shown reproductive toxicity in animal studies. There was a decrease in fertility associated with the pharmacological effects of the preparation. No teratogenic effects of amisulpride have been noted.
Clinical data on use during pregnancy are limited. Accordingly, the safety of amisulpride during pregnancy has not been established. The use of amisulpride is not recommended during pregnancy unless the benefits justify the potential risks.
If the preparation is used during pregnancy, the side effects of amisulpride may occur in newborns. In the third trimester of pregnancy, there is a risk of adverse reactions such as extrapyramidal syndromes and / or withdrawal syndrome, which may vary in severity and duration after delivery. Adverse reactions such as agitation, hypertonicity, hypotension, tremor, drowsiness, respiratory distress syndrome or feeding difficulties have been reported. In this regard, careful monitoring of newborns is necessary.
Due to the lack of information on the penetration of amisulpride into breast milk, breast-feeding is contraindicated.
Children
The efficacy and safety of amisulpride when used from puberty to 18 years of age have not been established; data on the use of amisulpride in children with schizophrenia are limited. For this reason, the use of amisulpride between puberty and 18 years of age is not recommended. Amisulpride is contraindicated in children under 15 years of age due to lack of clinical data.
Drivers
Patients, especially those who drive a car and work with other mechanisms, should be warned about the risk of developing drowsiness, dizziness in connection with the use of this preparation.

Overdose

To date, there are few data regarding acute overdose of amisulpride. The reported symptoms are mainly the result of an increase in pharmacological activity, which is clinically manifested in dizziness, sedation, coma, arterial hypotension and extrapyramidal symptoms.
There have been reports of fatal cases when used simultaneously with other psychotropic preparations.
The specific antidote for amisulpride is unknown. In the event of an acute overdose, it should be determined whether another preparation was used at the same time and appropriate measures should be taken:
  • careful monitoring of vital functions;
  • monitoring of cardiac activity (danger of prolongation of the QT interval) until the patient has completely recovered;
  • in case of severe extrapyramidal symptoms, it is necessary to prescribe anticholinergics;
  • Since amisulpride is poorly dialyzed, the ability of hemodialysis to remove this preparation  compound is limited.

Side effects

From the side of the nervous system. Very often: possible extrapyramidal symptoms (tremor, rigidity, hypertension, increased salivation, akathisia, hypokinesia, dyskinesia). In most cases, they are moderately pronounced at maintenance doses and partially reversible without discontinuation of amisulpride when prescribing anticholinergic antiparkinsonian preparations. The frequency of extrapyramidal symptoms, which depends on the dose, is very low in patients who are treated for predominantly negative symptoms with doses of 50-300 mg / day. Often: acute dystonia is possible (spasmodic torticollis, oculogyric crises, trismus, and so on). It is reversible without discontinuation of amisulpride when an anticholinergic antiparkinsonian is prescribed. Drowsiness. Infrequently, tardive dyskinesia, characterized by involuntary movements of the tongue and/or facial muscles, has been reported, usually after prolonged use of the preparation. Anticholinergic antiparkinsonian preparations are ineffective or may cause an increase in symptoms. Seizures.
From the nervous system: insomnia, anxiety, agitation, frigidity.
From the digestive system: constipation, nausea, vomiting, dry mouth.
From the endocrine system. An increase in the level of prolactin in the blood plasma, which is reversible after discontinuation of the preparation. This can cause such clinical symptoms: galactorrhea, amenorrhea, gynecomastia, chest pain, erectile dysfunction.
From the side of metabolism and nutrition: weight gain, hyperglycemia.
From the side of the cardiovascular system: arterial hypotension, bradycardia.
From the immune system: allergic reactions.

Storage conditions

Store in the original packaging at a temperature of 15-25°C, in a dry, dark place and out of the reach of children.
Expiration date - 36 months.

Tags: Solex

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