Phenobarbital induces liver enzymes and, accordingly, can accelerate the metabolism of some preparations that are metabolized by liver enzymes (for example, coumarin derivatives, antibiotics, and sulfonamides). Phenobarbital enhances the effect of analgesics, anesthetics, anesthetics, neuroleptics, tranquilizers; reduces the effect of paracetamol, indirect anticoagulants, metronidazole, tricyclic antidepressants, salicylates, digitoxin.

Possible influence on the blood concentration of phenytoin, as well as carbamazepine and clonazepam. MAO inhibitors prolong the effect of phenobarbital. Rifampicin may reduce the effect of phenobarbital. When used with gold preparations, the risk of kidney damage increases. With long-term simultaneous use with non-steroidal anti-inflammatory preparations, there is a risk of stomach ulcers and bleeding. The simultaneous use of preparations containing phenobarbital with zidovudine increases the toxicity of both preparations. The interaction of Valocordin (containing phenobarbital) with lamotrigine, thyroid hormones, doxycycline, chloramphenicol, antifungal preparations (azole group), griseofulvin, GCS, oral contraceptives is undesirable due to the possible weakening of the action of these preparations.

Increases the toxicity of methotrexate.

Symptoms acute (from mild to moderate) poisoning with barbiturates: dizziness, fatigue, deep sleep from which the patient cannot be awakened.

Hypersensitivity reactions may occur: angioedema, urticaria, itching, rash.

Acute severe poisoning: deep coma accompanied by tissue hypoxia, shallow breathing, first accelerated and then slowed down, increased heart rate, arrhythmia, hypotension, bradycardia, vascular collapse, reduction or loss of reflexes, nystagmus, headache, nausea, weakness, heart failure activity, a decrease in body temperature, a decrease in heart rate, a decrease in diuresis.

Failure to provide timely medical assistance may result in death as a result of vascular insufficiency, respiratory paralysis, or pulmonary edema.

Long-term use of preparations containing bromine can lead to bromine poisoning, which is characterized by the following symptoms: confusion, ataxia, apathy, depressed mood, conjunctivitis, colds, acne or purpura.

Treatment. Cases of acute valocordin poisoning should be treated in the same way as poisoning with other hypnotics and barbiturates, depending on the severity of the symptoms of poisoning. The patient must be hospitalized in the intensive care unit. Breathing and blood circulation require stabilization. Respiratory failure requires artificial respiration, shock is stopped by the administration of plasma and plasma substitutes. If a lot of time has passed after taking the preparation, it is necessary to wash the stomach (inject 10 g of activated carbon powder and sodium sulfate into the stomach). In order to quickly remove barbiturates from the body, it is possible to perform forced diuresis with alkalis, as well as hemodialysis and / or hemoperfusion.

Treatment of bromine poisoning: the removal of bromine ions from the body can be accelerated by the introduction of a significant amount of table salt solution with the simultaneous introduction of saluretic agents.

In the event of hypersensitivity reactions, prescribe desensitizing preparations.

In the original packaging at a temperature not higher than 25 °C.