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Treatment and prevention of magnesium deficiency, which may be manifested by: nervousness, irritability, mood swings, feeling mild anxiety accompanied by palpitations, anxiety, temporary fatigue, lethargy, sleep disturbances in low mood, muscle cramps, tingling or twitching of the eyelids. Supplementing a magnesium deficiency can alleviate these symptoms. Continuation of treatment is not recommended in the absence of improvement after one month of use. It is used in adults and children aged 6 years and above.


The active substances of the drug are magnesium citrate and pyridoxine hydrochloride (vitamin B6). One film-coated tablet contains 60 mg of magnesium ions in the form of magnesium citrate (Magnesii citras) and 6.06 mg of pyridoxine hydrochloride (Pyridoxini hydrochloridum). The other ingredients are: tablet core: microcrystalline cellulose, crospovidone (type A), croscarmellose sodium, colloidal anhydrous silica, magnesium stearate; tablet coating: polyvinyl alcohol, talc, titanium dioxide (E171), glycerol monocaprylocaproate (type 1), sodium laurilsulfate.


Magnesium plays an important role in the contraction of the heart muscle and affects the state of neuromuscular excitability. Its presence is essential for the proper course of many biochemical processes in the body. In addition, it plays a biological role involving the activation of a number of enzymes.


Adults: 5 to 6 tablets a day, in 2 or 3 divided doses. Children and adolescents: age 6-14, body weight 21-30 kg: 3 to 4 tablets a day in 2 or 3 divided doses; age 6-14 years, weight 31-39 kg: 4 to 5 tablets a day in 2 or 3 divided doses; age 14-18 years, body weight over 40 kg: 5 to 6 tablets a day in 2 or 3 divided doses. The drug should be taken with a meal, drinking plenty of water (one glass).


Hypersensitivity to any of the ingredients of this drug; known hypermagnesaemia in the patient; acute renal failure; evidence of significant arterial hypotension; atrioventricular block; the patient is diagnosed with myasthenia gravis disease. Due to the risk of high potassium levels in the blood, special care should be taken in patients with moderate renal insufficiency. If the patient is pregnant, thinks she may be pregnant, plans to have a baby or is breastfeeding, consult a doctor before taking this medicine. The drug can be used during pregnancy and breastfeeding only in consultation with a doctor. The recommended dose of vitamin B6 during breastfeeding should not exceed 20 mg a day. The drug should not be used in children under 6 years of age and weighing less than 20 kg. If a dose is missed, do not double the dose to make up.


The drug should be stored at a temperature below 30 degrees C, out of the sight and reach of children. The expiry date on the carton or blister refers to the last day of that month. After this period, you should not take this medication. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist for instructions on how to dispose of unused drugs.

Side effects

Rare: abdominal pain, loose stools or diarrhea at the start of treatment (usually mild and transient); redness of the skin; very rare: allergic reactions. The drug administered in a dose higher than the recommended dose may cause diarrhea; long-term use of high doses of magnesium may contribute to the development of caries; long-term use of magnesium may increase blood potassium levels, especially in patients with controlled potassium intake and poor kidney function. The use of pyridoxine over a long period of time (several months or years) may cause disturbance of the sensory nerves, with symptoms such as numbness and impaired sense of position, tingling in the hands and feet, and gradually progressive disturbance in coordination. In patients with normal renal function, overdosing with magnesium does not cause toxic reactions. Magnesium poisoning can occur in patients with renal insufficiency. Reporting side effects should be reported directly to your doctor or pharmacist.


Please inform your doctor or pharmacist if you are taking any of the following medicines as they may cause a deficiency of magnesium and / or vitamin B6, increasing their excretion from the body or poor absorption. In addition, when using these drugs, individual adjustment of the drug may be necessary: ​​some antibiotics (cisplatin, cyclosporin A, rifampicin, amphotericin B, penicillamine, inoniazid, cyclospherin); bisphosphonates (medicines to treat osteoporosis); diuretics (e.g. thiazides or furosemide); cetuximab or erlotinib (medicines to treat cancer); proton pump inhibitors (medicines to treat heartburn such as pantoprazole or omeprazole); foxarin (an antiviral drug); pentamidine (a medicine to treat parasitic or lung infections); hydralazine (a medicine to lower blood pressure); phosphates, iron compounds or calcium salts; contraceptives; laxatives. Tell your doctor or pharmacist if you are taking levodopa (a medicine for Parkinson's disease) as vitamin B6 may stop it from working. Medicines containing magnesium and certain antibiotics (fluoroquinolones, tetracyclines) or drugs used in the treatment of osteoporosis (the so-called bisphosphonates) should not be taken at the same time, because magnesium may reduce their absorption from the gastrointestinal tract. There should be a 2-3 hour interval between taking these drugs and this drug. There is a risk of hypermagnesaemia and symptoms of magnesium intoxication when concomitantly using magnesium preparations with lithium carbonate, potassium-sparing diuretics (such as amiloride and spironolactone), or with other drugs containing magnesium (such as laxatives, antacids). The risk is especially increased in people with kidney failure.


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