OFTAQUIX EYE DROPS 0,5% 5ML - MADE IN FINLAND - FREE SHIPPING
Product description
Oftaquix (Oftakvics, Oftakwix) eye drops - is an ophthalmic agent whose active ingredient is levofloxacin, which has an antimicrobial effect on various groups of pathogenic microorganisms. The preparation is used in the treatment of eye infections caused by susceptible to levofloxacin microorganisms.
Antimicrobial preparation from the group of fluoroquinolones.
Levofloxacin is the L-isomer of the racemic preparation substance ofloxacin. The antibacterial activity of ofloxacin is mainly related to the L-isomer. Levofloxacin blocks DNA-gyrase and topoisomerase IV, disrupts supercoiling and cross-linking of DNA gaps, suppresses DNA synthesis, causes profound morphological changes in the cytoplasm, cell wall and membranes.
It is active against gram-negative aerobes: Branchamella (Moraxella) cataralis, Haemophilus influenzae, Neisseria gonorrhoeae, Pseudomonas aeruginosa; Gram-positive aerobes: Staphyloccocus aureus, Streptococcus pneumoniae, Streptococcus pyogenes.
Pharmacokinetics
After instillation into the eye, levofloxacin is well preserved in the lacrimal film. In studies on healthy volunteers, it was shown that the average concentrations of levofloxacin in the tear film, measured at 4 and 6 hours after topical application, were 17.0 μg / ml and 6.6 μg / ml, respectively. In five of the six subjects, the concentrations of levofloxacin were 2 μg / ml and higher 4 hours after instillation. In four out of six subjects, this concentration was preserved 6 hours after instillation.
The average concentration of levofloxacin in the application of eye drops Oftakwix in aqueous humor is statistically significant (p = 0.0008) above the mean concentration of ofloxacin (1139.9 ± 717.1 ng / ml and 621.7 ± 368.7 ng / ml, respectively). The average concentration of levofloxacin in the blood plasma after 1 h after application is from 0.86 ng / ml to 2.05 ng / ml.
Cmax levofloxacin in plasma, equal to 2.25 ng / ml, was detected on the fourth day after 2 days of the preparation every 2 hours up to 8 times / day. The Cmax of levofloxacin, achieved on the fifteenth day, was more than 1000 times lower than the concentration noted after ingestion of standard doses of levofloxacin.
Indications:
- Treatment of superficial bacterial infections of the eye of patients aged 1 year and older.
- Prophylaxis of complications after surgical and laser operations on the eye.
Contraindications:
- Hypersensitivity to any of the components of Oftakwix or to other quinolones.
- Contraindicated in pregnancy and lactation.
Special instructions:
- Ophthalmic eye drops, 5 mg / ml, can not be administered subconjunctivally and directly forward camera of the eye.
- With the simultaneous use of other ophthalmic agents, the interval between the instillations should be at least 15 minutes.
- Drops should not be used during the wearing of hydrophilic (soft) contact lenses, due to the presence of benzalkonium chloride in the drops.
- To avoid contamination of the tip of the dropper and solution, the tip of the dropper should not touch the eyelids and tissues around the eye.
Side effects:
Often (1-10%): a burning sensation in the eye, reduced visual acuity, the appearance of mucous cords.
Rarely (0.1-1%): blepharitis, chemosis, papillary sprains on the conjunctiva, edema of the eyelids, unpleasant sensations in the eye, itching in the eye, eye pain, conjunctival hyperemia, conjunctival follicles, dry eye syndrome, erythema eyelids, eye irritation, contact dermatitis, photophobia and allergic reactions.
Other: during clinical trials - headache, rin
Overdose:
The total amount of levofloxacin contained in one bottle of eye drops is too low to cause toxic reactions even after accidental ingestion. After topical administration of an excessive dose of eye drops, Oftakwix, 5 mg / ml, the eye should be rinsed with clean (tap) water at room temperature.
Suggested Use:
Locally, in the affected eye.
1-2 drops in the affected eye (a) every two hours up to 8 times a day during the waking period during the first 2 days, then four times a day from 3 to 5 days. The duration of treatment is determined by a doctor, usually 5 days.
Packaging:
- Comes in original packaging. Item is brand new and unopened.
Storage:
- Keep away from direct sunlight.
- Keep locked and away from children.
- Store in dry place at room temperature.
- Do not exceed storage temperature higher than 25 C
Important notice- the outer box design may vary before prior notice!
Tags: OFTAQUIX
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