Amizonchik 10mg/ml syrup — Made in Ukraine — Free Delivery
(Amizonchik )
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Description Amizonchik 10mg/ml syrup — Made in Ukraine — Free Delivery
Pharmacological properties
Pharmacodynamics. Enisamium iodide is a derivative of isonicotinic acid. It has an inhibitory effect on influenza viruses, exhibits interferonogenic properties, increases the body's resistance to viral infections, has anti-inflammatory, antipyretic and analgesic effects.
The antiviral effect of Amizonchik is associated with its direct effect on the hemagglutinins of the influenza virus, as a result of which the virion loses its ability to attach to target cells for further replication.
The anti-inflammatory effect is the result of stabilization of cell and lysosomal membranes, slowing down the degranulation of basophils, antioxidant action, normalization of the level of prostaglandins, cyclic nucleotides and energy metabolism in the focus of inflammation. The antipyretic properties of this agent are due to the effect on the thermoregulatory centers of the brain. The analgesic effect of the agent is carried out through the reticular formation of the brain stem.
Enisamium iodide enhances persistent immunity by increasing the level of endogenous interferon in blood plasma by 3-4 times, lysozyme and increasing the titer of antibodies to infectious agents, as well as cellular immunity - by stimulating the functional activity of T-lymphocytes and macrophages. This agent is a powerful inducer of endogenous interferon.
Pharmacokinetics. After oral administration, enisamium iodide quickly enters the bloodstream, Cmax is noted 2–2.5 hours after administration. T1 / 2 is 13.5-14 hours. The preparation is metabolized in the liver, but rapidly excreted from tissues (T1 / 2 = 2-3 hours). It is excreted from the body by 90–95% in the urine in the form of metabolites.
Indications
Treatment for influenza and ARVI.
Application
The preparation is recommended for the treatment of children from the age of 3 years. the syrup is taken orally, preferably after a meal, with a little water.
Children aged 3-4 years - 5 ml (50 mg) 3 times a day.
Children aged 4-5 years - 6 ml (60 mg) 3 times a day.
Children aged 5-6 years - 7 ml (70 mg) 3 times a day.
For children aged 6–12 years, the preparation should be prescribed in the form of tablets. If a child cannot swallow tablets, the preparation should be taken 12 ml (120 mg) 2-3 times a day.
Do not exceed recommended doses.
For dosing the syrup, a 5 ml dosing spoon with a 1 ml graduation is included. If it is necessary to measure a dose above 5 ml, first measure out the first 5 ml of syrup, and then the rest of the dose.
The course of treatment is 5-7 days, depending on the severity of the disease and the therapeutic effect.
Contraindications
Hypersensitivity to the components of the preparation and iodine preparations, the presence of allergic reactions regardless of the nature of the allergen in the history, severe organic lesions of the liver and kidneys, tuberculosis, Dühring's herpetiformis dermatitis (Dühring-brock syndrome), manifest and latent hyperthyroidism, autonomous adenoma, focal and diffuse autonomous foci of the thyroid gland, hemorrhagic diathesis.
Side effects
From the immune system: hypersensitivity reactions;
- on the part of the skin and subcutaneous tissue: rash, itching, urticaria, erythema, angioedema;
- from the gastrointestinal tract: dry mouth, dysgeusia (bitter taste in the mouth), swelling of the oral mucosa, hypersalivation, discoloration of the tongue (staining yellow), nausea, vomiting, diarrhea, dyspepsia, abdominal pain, pain in the upper part abdomen, bloating;
- from the respiratory system, chest and mediastinal organs: dyspnea, throat irritation;
- from the nervous system: headache, dizziness;
- general disorders and disorders at the injection site: asthenia, peripheral edema;
- laboratory and instrumental data: increase in blood pressure, decrease in blood pressure.
Special instructions
Care should be taken to prescribe the preparation to patients with thyroid diseases, especially those with nodular or multinodular goiter at the age of 40 years, due to the risk of decompensation of the functional autonomy of the thyroid gland (with the exception of the contraindications indicated in the section).
The syrup contains sorbitol, therefore patients with hereditary intolerance to some sugars should consult a doctor before taking this medicine. Patients with rare hereditary fructose intolerance should not take this preparation.
Sorbitol can also have a mild laxative effect. The energy value of 1 g of sorbitol is 2.6 kcal.
This medicinal product contains, in a minimum daily dose (15 ml), 1.89 mmol (or 43.5 mg) sodium. Caution should be exercised when administered to patients on a sodium-controlled diet.
Use during pregnancy and lactation. The use of the preparation during pregnancy and lactation is contraindicated.
Children. The preparation is used to treat children from the age of 3 years.
The ability to influence the reaction rate when driving or working with other mechanisms. The preparation is not intended for use in this category of patients.
Interactions
Amizonchik enhancing and immunomodulating agents. the combination of this preparation with ascorbic acid and other vitamins is advisable. patients with thyroid dysfunction are not recommended to use the preparation in combination with interferon.
Overdose
In case of an overdose, an increase in the manifestations of side reactions is possible: staining of the mucous membrane in brown, vomiting, abdominal pain and diarrhea. development of edema, erythema, acne-like and bullous eruptions, fever is possible.
Treatment: gastric lavage, symptomatic treatment.
Storage conditions
In its original packaging at a temperature not exceeding 25 ° C.
Tags: Amizon
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