Amoksiklav Quicktab (Amoxicillin) 875mg/125mg 14 tablets — Made in Poland by Sandoz — Free Delivery

Pharmacodynamics. mechanism of action. Amoxicillin is a semi-synthetic penicillin (beta-lactam antibiotic) that inhibits one or more enzymes (often called penicillin-binding proteins - psb) in the biosynthetic metabolism of bacterial peptidoglycan, which is an integral structural component of the bacterial cell wall. inhibition of peptidoglycan synthesis leads to a weakening of the cell wall, resulting in lysis and cell death.

Amoxicillin is sensitive to degradation by beta-lactamases produced by resistant bacteria, therefore, the spectrum of activity of amoxicillin in monotherapy does not include organisms producing these enzymes.

Clavulanic acid is a beta-lactam structurally related to penicillins. It deactivates some beta-lactamase enzymes, thereby preventing the inactivation of amoxicillin. Clavulanic acid alone has no clinically beneficial antibacterial effect.

Pharmacokinetics / pharmacodynamics ratio. Time exceeding the MIC (VMPK) is considered the main factor determining the effectiveness for amoxicillin.

Mechanisms of resistance. There are two mechanisms of amoxicillin / clavulanic acid resistance:

- inactivation by bacterial beta-lactamases, which are not inhibited by themselves by clavulanic acid, including class B, C and D;

- transformation of PSB, which reduces the affinity of the antibacterial drug to the target.

Bacterial impermeability or the reflux pump mechanism can cause or contribute to bacterial resistance, particularly in gram-negative bacteria.

Limit values. The European Committee for Antimicrobial Susceptibility Testing (EUCAST) MIC limits for amoxicillin / clavulanic acid: