Aquadetrim vitamin D3 aqueous solution for oral administration 15000 IU/ ml 10 ml — Made in Poland — Free Delivery

(Aquadetrim vitamin D3)
Aquadetrim vitamin D3 aqueous solution for oral administration 15000 IU/ ml 10 ml — Made in Poland — Free Delivery
Availability: In Stock
Medana Pharma Brand: Medana Pharma

Product description

Vitamin D3 is an active antirachitic factor. The most important function of vitamin D is to regulate calcium and phosphate metabolism, which contributes to proper mineralization and skeletal growth.

Vitamin D3 is a natural form of vitamin D that is produced in animals and humans. Compared to vitamin D2, its activity is 25% higher.

It is essential for the functioning of the parathyroid glands, intestines, kidneys and skeletal system. Plays an essential role in the absorption of calcium and phosphates from the intestines, in the transport of mineral salts and in the process of bone calcification, regulates the excretion of calcium and phosphates by the kidneys. The concentration of calcium ions affects a number of important biochemical processes that maintain the tone of the muscles of the skeletal muscles, take part in the conduct of nervous excitement and affect blood clotting. Vitamin D3 is also involved in the functioning of the immune system, affects the production of lymphokines.

Lack of vitamin D3 in food, weakening of its absorption, calcium deficiency, as well as lack of exposure to sunlight during the period of rapid growth of the child lead to rickets, and in adults - to osteomalacia, in pregnant women - to the appearance of symptoms of tetany and non-formation of tooth enamel in newborns ...

Women in menopause, who often suffer from osteoporosis, due to hormonal imbalance, need to increase the dose of vitamin D3.

Features of the

An aqueous solution of vitamin D3 is better absorbed than an oil solution. Premature babies have insufficient formation and flow of bile into the intestines, which disrupts the absorption of vitamins in the form of oil solutions.

After oral administration, cholecalciferol is absorbed in the small intestine.

Distribution. Penetrates through the placental barrier and into breast milk.

Metabolism. It is metabolized in the liver and kidneys, turning into an active metabolite - calcitriol, which combines with a carrier protein and is transported to target organs (intestines, bones, kidneys). The half-life in the blood is several days and can be prolonged in the case of kidney disease.

Excretion. It is excreted in urine and feces.

Vitamin D3 is involved in the regulation of phosphorus and calcium metabolism in the body 6 hours after taking the preparation.

After taking vitamin D3, a significant increase in the level of cholecalciferol in the blood serum is observed after 48 hours.


Prevention of rickets;

  • prevention of vitamin D3 deficiency in high-risk groups who do not have malabsorption disorders;
  • prevention of rickets in premature newborns;
  • prevention of vitamin D3 deficiency in malabsorption;
  • treatment of rickets and osteomalacia;
  • maintenance treatment for osteoporosis;
  • treatment of hypoparathyroidism.


Hypersensitivity to preparation components, hypercalcemia and / or hypercalciuria, hypervitaminosis D, sarcoidosis, renal failure, nephrolithiasis, tuberculosis. Pseudohypoparathyroidism (the need for vitamin D may be lower than during the period of normal vitamin sensitivity).

Taking vitamin D can put you at risk of overdose. In such situations, vitamin D should be used in other dosage forms in order to make it easier to control the concentration. The preparation is contraindicated in patients with rare hereditary fructose intolerance, glucose-galactose malabsorption or sucrose-isolmaltose insufficiency.

Method of administration and dosage

Take orally.

Prevention of rickets: the recommended dose is 1 drop (about 500 IU of vitamin D3) per day.

Prevention of vitamin D3 deficiency in high-risk patients who do not have absorption disorders: the recommended dose is 1 drop (about 500 IU of vitamin D3) per day.

Osteoporosis maintenance treatment: The recommended dose is 2 drops (about 1000 IU of vitamin D3) per day.

Prevention of rickets in premature newborns: the dose is determined by the doctor. The total recommended dose is 2 drops (about 1000 IU of vitamin D3) per day.

Prevention of vitamin D3 deficiency in malabsorption: the dose is determined individually by the doctor. The total recommended dose is 6-10 drops (about 3000-5000 IU of vitamin D3) drops per day.

Treatment of rickets and osteomalacia: the dose is determined individually by the doctor, depending on the course and severity of the disease. The general recommended dose for treatment of vitamin D3 deficiency for infants and children is 2-10 drops (about 1000-5000 IU of vitamin D3) per day. The dose for the treatment of vitamin D3 deficiency is determined individually, depending on the course and severity of the disease.

Treatment of hypoparathyroidism: the recommended dose depends on the level of serum calcium and is 20-40 drops (about 10,000-20,000 IU of vitamin D3) per day. If it is necessary to take higher doses of cholecalciferol, a higher dosage should be used.


Vitamin D3 regulates the metabolism of calcium and phosphate, after an overdose, hypercalcemia, hypercalciuria, renal calcifications and bone damage, as well as changes in the cardiovascular system, occur. Hypercalcemia occurs after taking 50,000-100,000 IU of vitamin D3 per day.

In case of an overdose, the following effects can develop: muscle weakness, loss of appetite, nausea, vomiting, constipation, polydipsia, polyuria, drowsiness, photosensitivity, pancreatitis, rhinorrhea, hyperthermia, decreased libido, conjunctivitis, hypercholesterenemia, arterial hypotension uremia. Common symptoms include muscle and joint pain, headache, and weight loss. Dysfunction of the kidneys develops with albuminuria, erythrocyturia and polyuria, increased loss of potassium, hypostenuria, nocturia and an increase in blood pressure of a moderate degree.

In severe cases, clouding of the cornea is possible, less often - edema of the papilla of the optic nerve, inflammation of the iris up to the development of cataracts.

Kidney stones and calcification of soft tissues such as blood vessels, heart, lungs and skin can form.

Cholestatic jaundice rarely develops.


Overdose requires treatment for hypercalcemia. You must stop taking the preparation. Depending on the degree of hypercalcemia, a diet low in calcium or without calcium, drinking a lot of fluids, forced diuresis induced by the administration of furosemide, and taking glucocorticoids and calcitonin are recommended.

With normal renal function, the calcium level significantly decreases with the introduction of an infusion solution of sodium chloride (3-6 liters for 24 hours) with the addition of furosemide, in some cases, 15 mg / kg / hour of sodium edetate should also be used, constantly monitoring the level of calcium and ECG. In oligoanuria, on the contrary, hemodialysis is necessary. There is no specific antidote.

Application features

The preparation should be used with caution in immobilized patients, patients taking thiazides, cardiac glycosides, patients with cardiovascular diseases.

During the use of the preparation Aquadetrim ® Vitamin D3, it is necessary to take into account the additional intake of vitamin D3 (joint intake of other preparations containing vitamin D). Combination therapy with vitamin D or calcium should be carried out only under medical supervision and under the control of serum and urine calcium levels.

Individual provision of a specific need should take into account all possible sources of this vitamin.

Too high doses of Aquadetrim ® Vitamin D3, used for a long time, or loading doses can cause chronic hypervitaminosis D3.

The determination of the child's daily requirement for vitamin D and the method of its use should be established individually and each time subjected to verification during periodic studies, especially in the first months of life.

The preparation should be used with caution in newborns born with a small anterior crown.

Do not take simultaneously Aquadetrim ® Vitamin D3 with high doses of calcium.

During treatment, it is recommended to control the level of calcium, phosphate and sugar in serum and urine.

It should be used with caution in patients with impaired renal function. Long-term use of the preparation requires monitoring of renal function by serum creatinine levels.

The preparation should be used with caution in pregnant and breastfeeding women.


Active ingredient in 1 ml (about 30 drops) solution:

cholecalciferol - 15000 IU

excipients: macrogolglycerol ricinoleate; sucrose; sodium hydrogen phosphate dodecahydrate; citric acid, monohydrate, anise flavor; benzyl alcohol; purified water.

1 drop contains approximately 500 IU of vitamin D3.

Storage conditions

Store at a temperature not exceeding 25 ° C in its original packaging to protect from light.

Keep out of the reach of children.

Shelf life is 3 years.

Do not use after the expiration date printed on the package.

After opening the bottle, store with a tightly closed cap for 6 months.

During long-term treatment with Aquadetrim® Vitamin D3, it is necessary to regularly monitor the level of creatinine in the blood and the level of calcium in the blood serum and urine. If necessary, the dose should be adjusted depending on the concentration of calcium in the blood serum.

Tags: Aquadetrim

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