Special instructions

The ability to influence the speed of reactions when driving vehicles or working with other mechanisms. Does not affect in recommended doses.

Interactions

• With benzylpenicillin, tetracycline, salicylates - an increase in the concentration of preparations in the blood;
• with ethinyl estradiol (ascorbic acid - in a dose of 1 g/day) - an increase in the concentration of ethinyl estradiol (including oral contraceptives) in the blood;
• with oral contraceptives - a decrease in the concentration of preparations in the blood;
• with tetracycline and acetylsalicylic acid - increased excretion of ascorbic acid with urine;
• high doses of ascorbic acid can lower the pH of urine, resulting in decreased tubular reabsorption of amphetamine and tricyclic antidepressants used simultaneously;
• with deferoxamine - increased removal of iron;
• with heparin, indirect anticoagulants, antipsychotic preparations, phenothiazine derivatives - decrease in the effectiveness of preparations;
• with isoprenaline - reduction of the chronotropic effect of the preparation;
• with short-acting sulfonamides - increased development of crystalluria;
• with preparations that have an acidic reaction - slowing down the excretion of preparations by the kidneys;
• with preparations that have an alkaline reaction, mexiletine, amphetamine, tricyclic antidepressants - acceleration of the release of preparations by the kidneys;
• with acetylsalicylic acid - increased urinary excretion of ascorbic acid and decreased excretion of acetylsalicylic acid;
• with barbiturates, primidone - increased excretion of ascorbic acid with urine;
• with preparations of the quinoline series, calcium chloride, salicylates, GCS - with long-term use - depletion of ascorbin reserves with long-term use or use in high doses, disulfiram-ethanol interaction is possible.

Ascorbic acid increases the concentration of salicylates in the blood (increases the risk of crystalluria).

Participates in the metabolism of phenylalanine, tyrosine, folic acid, norepinephrine, histamine.

The simultaneous use of ascorbic acid and deferoxamine increases the tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system.

Incompatibility. Ascorbic acid has a high oxidation-reduction potential, so it can change the chemical composition of other medicines. When considering the possibility of simultaneous use with other medicinal products, it is necessary to ensure their compatibility.

Overdose

Acute poisoning with ascorbic acid has not been described. high doses of ascorbic acid can cause gastrointestinal disturbances, including diarrhea, and lead to hyperoxaluria and the formation of oxalate stones. doses of 600 mg/day have a diuretic effect. with intravenous administration in high doses, there may be a threat of termination of pregnancy. with a single use of excessive doses of the preparation, nausea, vomiting, bloating, abdominal pain, itching, skin rashes, and increased excitability may occur.

Treatment: discontinuation of the preparation, symptomatic therapy.

Storage conditions

In the original packaging at a temperature not higher than 25 °C. Do not freeze.