Astracitrone powder for oral solution, 20g x 10 sachets — Made in Ukraine — Free Delivery

The preparation is contraindicated during pregnancy or lactation.

The ability to influence the reaction rate when driving or driving other mechanisms.

During treatment, it is not recommended to drive vehicles or other mechanisms, as the preparation may cause drowsiness.

Method of administration and dosage.

Dissolve the contents of the sachet in a glass of hot water (not boiling water) and drink. taking the preparation can be repeated every 3-4 hours, but not more than 3 sachets per day.

The duration of treatment is up to 5 days.

The preparation is contraindicated in children under 14 years of age.

Paracetamol. overdose, as a rule, is caused by paracetamol and is manifested by pallor of the skin, anorexia, nausea, vomiting, abdominal pain, hepatonecrosis, increased activity of hepatic transaminases and an increase in prothrombin index. in case of an overdose, there may be increased sweating, psychomotor agitation or depression of the central nervous system, drowsiness, impaired consciousness, heart rhythm disturbances, tachycardia, extrasystole, tremor, hyperreflexia, convulsions. when using large doses, disorientation, agitation, dizziness, sleep disturbance, heart rhythm and pancreatitis can be observed, nephrotoxicity is also possible (renal colic, interstitial nephritis, papillary necrosis). Acute renal failure with acute tubular necrosis may present with severe lumbar pain, hematuria, proteinuria, and develop even in the absence of severe liver damage.

In severe poisoning, impaired liver function can progress to encephalopathy with impaired consciousness, hemorrhage, hypoglycemia, cerebral edema, in some cases - with a fatal outcome. Liver damage is possible in adults who have taken more than 10 g, and in children who have taken more than 150 mg / kg of body weight. Taking 5 g or more of paracetamol can lead to liver damage in patients with risk factors (long-term treatment with carbamazepine, phenobarbital, phenytoin, primidone, rifampicin, St. , cystic fibrosis, HIV infection, hunger, cachexia).

The first clinical signs of hepatonecrosis may appear 12–48 hours after an overdose. Disorders of glucose metabolism and metabolic acidosis may occur. With prolonged use of high doses, aplastic anemia, pancytopenia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia are possible.

In case of an overdose of phenylephrine, hyperhidrosis, psychomotor agitation or depression of the central nervous system, headache, dizziness, drowsiness, impaired consciousness, arrhythmias, tremors, hyperreflexia, convulsions, nausea, vomiting, irritability, anxiety, arterial hypertension occur.

With an overdose of pheniramine, atropine-like symptoms occur: mydriasis, photophobia, dry skin and mucous membranes, hyperthermia, intestinal atony. Inhibition of the central nervous system leads to disruption of the respiratory and cardiovascular systems (bradycardia, arterial hypotension, collapse).

In case of an overdose of ascorbic acid, nausea, vomiting, bloating and abdominal pain, itching, skin rashes, and increased excitability occur. Doses over 3000 mg can cause temporary osmotic diarrhea and gastrointestinal disorders, impaired metabolism of zinc, copper, myocardial dystrophy, glucosuria, crystalluria, nephrolithiasis.

Treatment. In case of an overdose, an ambulance is needed. The patient should be taken to hospital immediately, even if there are no early symptoms of overdose. Symptoms may be limited to nausea and vomiting, or may not reflect the severity of the overdose or the risk of organ damage. Treatment with activated charcoal should be considered if an overdose of paracetamol has been taken within 1 hour. The concentration of paracetamol in blood plasma should be measured 4 hours or later after ingestion (earlier concentrations are not reliable). Treatment with N-acetylcysteine ​​can be applied within 24 hours after taking paracetamol, but the maximum protective effect occurs when it is used within 8 hours after taking it. The effectiveness of the antidote decreases sharply after this time. If necessary, the patient is injected intravenously with N-acetylcysteine ​​according to the established list of doses. In the absence of vomiting, oral methionine can be used as an appropriate alternative in remote areas outside the hospital.