Cerucal 10 mg 50 tablets — Made in Hungary — Free Delivery
(Cerucal)
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Description Cerucal 10 mg 50 tablets — Made in Hungary — Free Delivery
Product description
Tablets "Cerucal®" are used for the following indications:
- adults - to prevent nausea and vomiting caused by radiation therapy, delayed nausea and vomiting caused by chemotherapy, as well as for the symptomatic treatment of nausea and vomiting, including those associated with acute migraine (in combination with oral analgesics to improve their absorption).
- children - only as a second-line preparation to prevent delayed nausea and vomiting caused by chemotherapy.
Compound
The active ingredient is metoclopramide hydrochloride (one tablet contains metoclopramide hydrochloride (in the form of metoclopramide hydrochloride monohydrate) 10 mg).
Excipients: potato starch, lactose monohydrate, gelatin, precipitated silicon dioxide, magnesium stearate.
Contraindications
- hypersensitivity to metoclopramide or to any other component of the preparation;
- gastrointestinal bleeding;
- mechanical intestinal obstruction;
- gastrointestinal perforation;
- confirmed or suspected pheochromocytoma, due to the risk of severe bouts of hypertension;
- a history of tardive dyskinesia caused by antipsychotics or metoclopramide;
- epilepsy (increased frequency and intensity of seizures);
Parkinson's disease;
- concomitant use with levodopa or dopaminergic agonists;
- established methemoglobinemia with the use of metoclopramide or a history of NADH-cytochrome-b5-reductase deficiency;
- prolactin-dependent tumors;
- increased convulsive readiness (extrapyramidal movement disorders);
- children's age up to one year, due to the increased risk of extrapyramidal disorders.
Mode of application
Take orally before meals without chewing, drinking plenty of fluids.
In order to minimize the risks of adverse reactions from the nervous system and other side effects, metoclopramide is prescribed only for short-term treatment (up to 5 days).
Adults
The usual therapeutic dose of metoclopramide is 10 mg up to 3 times a day. The maximum daily dose is 30 mg, 0.5 mg / kg of body weight. The maximum duration of use of metoclopramide is 5 days.
Children
The recommended dose of metoclopramide to prevent delayed nausea and vomiting caused by chemotherapy is 0.1-0.15 mg / kg body weight up to 3 times a day. The maximum daily dose is 0.5 mg / kg of body weight.
Dosing scheme:
- body weight 30-60 kg: single dose - 5 mg (up to 3 times a day);
- body weight> 60 kg: single dose - 10 mg (up to 3 times a day).
The maximum duration of use of metoclopramide is 5 days.
Application features
Pregnancy
Metoclopramide can be used during pregnancy if clinically necessary. Due to the pharmacological properties (as in other neuroleptics), in the case of the use of metoclopramide at the end of pregnancy, the appearance of an extrapyramidal syndrome in a newborn cannot be ruled out. It is necessary to avoid the use of metoclopramide at the end of pregnancy. When using metoclopramide, it is necessary to monitor the newborn.
Metoclopramide passes into breast milk in small amounts. Therefore, it is not recommended to use metoclopramide during breastfeeding. Consideration should be given to discontinuing metoclopramide in women who are breastfeeding.
Drivers
Metoclopramide can cause drowsiness, dizziness, dyskinesia, and dystonia, which can affect vision and the ability to drive vehicles or operate other automated systems.
Overdose
Symptoms
Drowsiness, suppressed level of consciousness, confusion, irritability, anxiety and its intensification, convulsions, extrapyramidal disorders, dysfunction of the cardiovascular system with bradycardia and increased or decreased blood pressure, hallucinations, respiratory arrest and cardiac activity.
Treatment
In the case of the development of extrapyramidal symptoms associated or not associated with an overdose, only symptomatic treatment is carried out (benzodiazepines - for children and / or anticholinergic antiparkinsonian preparations - for adults). According to the clinical condition, it is necessary to carry out symptomatic treatment and constant monitoring of the functions of the cardiovascular and respiratory systems.
Side effects
On the part of the blood and lymphatic system: methemoglobinemia, which may be associated with a deficiency of NADH-cytochrome b5 reductase, especially in infants, sulfhemoglobinemia, which is mainly associated with the concomitant use of high doses of preparations that release sulfur.
From the side of the cardiovascular system: bradycardia, especially when administered intravenously, cardiac arrest for a short time after injection, may be due to bradycardia, atrioventricular blockade, blockade of the sinus node, especially when used intravenously, prolongation of the QT interval, ventricular tachycardia of the "pirouette" type », Arterial hypotension, shock, fainting after intravenous administration, acute arterial hypertension in patients with pheochromocytoma, a temporary increase in blood pressure.
From the endocrine system: amenorrhea, hyperprolactinemia, galactorrhea, gynecomastia, menstrual irregularities.
From the gastrointestinal tract: nausea, dry mouth, constipation, diarrhea.
From the immune system: hypersensitivity, anaphylactic reactions (including anaphylactic shock), mainly when administered intravenously.
From the nervous system: dyskinetic syndrome, mainly in children (involuntary spasmodic movements, in particular in the head, neck and shoulders, tonic blepharospasm, spasm of the facial and chewing muscles, deviation of the tongue, spasm of the pharyngeal muscles and muscles of the tongue, improper maintenance of the head and neck, overstrain of the spine, spasmodic flexion of the arms, spasmodic extension of the legs), headache, dizziness, drowsiness, extrapyramidal disorders (which can occur even after using a single dose, mainly in children and adolescents, and / or when the recommended dose is exceeded), parkinsonism ( tremor, muscle stiffness, akinesia), akathisia, dystonia, dyskinesia, suppressed level of consciousness, tardive dyskinesia (which may be constant during or after long-term treatment, especially in elderly patients), neuroleptic malignant syndrome (characteristic symptoms: fever, muscle stiffness , loss of consciousness, fluctuations in blood pressure, convulsions (mainly in patients with epilepsy)).
From the side of the skin: rash, urticaria, hyperemia and itching of the skin, angioedema.
Mental disorders: depression, hallucinations, confusion, anxiety, restlessness.
Storage conditions
Store in its original packaging to protect from light at a temperature not exceeding 30 ° C, out of the reach of children.
The shelf life is 5 years.
Tags: Cerucal
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