Clofan 100mg 6 suppositories — Made in India — Free Delivery

Pharmacodynamics. The mechanism of the antimycotic action of clotrimazole is associated with the suppression of the synthesis of ergosterol, which leads to structural and functional damage to the cytoplasmic membrane.

Clotrimazole has a wide spectrum of antimycotic activity in vitro and in vivo, acts on dermatophytes, yeast, mold and dimorphic fungi.

Under appropriate testing conditions, the minimum inhibitory concentrations for these types of fungi are approximately 0.062–8.0 μg / ml of substrate.

The mechanism of action of clotrimazole is associated with primary fungistatic or fungicidal activity, depending on the concentration of clotrimazole at the site of infection.

In vitro activity is limited to the proliferating elements of the fungus; spores of the fungus have only a slight sensitivity.

In addition to the antimycotic activity, clotrimazole also acts on gram-positive microorganisms (streptococci, staphylococci, Gardnerella vaginalis) and gram-negative microorganisms (Bacteroids)).

In vitro, clotrimazole inhibits the growth of Corynebacteria and gram-positive cocci (with the exception of Enterococci) at a concentration of 0.5–10 μg / ml of substrate. Initially resistant strains of susceptible fungal species are rare. The development of secondary resistance during treatment in susceptible fungi has been very rare so far.

Preclinical studies conducted with the participation of volunteers using a single and repeated toxic dose did not reveal any harmful toxic, genotoxic effects and effects on reproduction.

Pharmacokinetics. Pharmacokinetic studies after vaginal administration have shown that only a small amount of clotrimazole (3–10%) is absorbed. Absorbed clotrimazole is rapidly metabolized in the liver to inactive metabolites. Therefore, the plasma Cmax of clotrimazole after vaginal administration at a dose of 500 mg was 10 ng / ml. This means that the occurrence of measurable systemic effects or side effects after intravaginal use of clotrimazole is unlikely.

Infections in the genital area (vaginitis) caused by fungi (usually of the genus candida) and superinfections caused by bacteria susceptible to clotrimazole.

Vaginal suppository 100 mg

The vaginal suppository should be inserted into the vagina as deeply as possible before going to bed. It is more convenient to administer the suppository lying on your back with slightly bent legs.

One course of therapy for 2 suppositories for three days or 1 suppository for six days.

A second course of therapy may be prescribed if needed.

Treatment should not be carried out during menstruation. Treatment should be completed before the onset of menstruation.

Do not use tampons, intravaginal irrigations, spermicides, or other vaginal products while using this preparation.

Sexual contact should be avoided while using this preparation , as the infection can be passed on to your partner.

Vaginal suppository 500 mg

Apply one vaginal suppository at night.

The vaginal suppository should be inserted into the vagina as deeply as possible before going to bed. It is more convenient to administer the suppository lying on your back with slightly bent legs.

A second course of therapy may be prescribed if needed.

Treatment should not be carried out during menstruation. Treatment should be completed before the onset of menstruation.

Do not use tampons, intravaginal irrigations, spermicides, or other vaginal products while using this preparation.

Sexual contact should be avoided while using this preparation, as the infection can be passed on to your partner.

Hypersensitivity to clotrimazole or other components of the preparation.

From the immune system: allergic reactions, including fainting, arterial hypotension, shortness of breath, urticaria, itching.

From the reproductive system and mammary glands: skin peeling in the genital area, itching, rash, edema, erythema, discomfort, burning, irritation, pelvic pain, vaginal bleeding.

From the gastrointestinal tract: abdominal pain.

Contact with eyes should be avoided. do not swallow.

The patient is advised to consult a doctor:

at the first manifestations of the disease;

if symptoms persist for 7 days;

if symptoms appear again within 2 months or more than 4 times during the last 12 months;

with established hypersensitivity to any antifungal agents or imidazole derivatives;

in the presence of a history of sexually transmitted diseases or a burdened history of sexually transmitted diseases in a partner;

if you have more than two episodes of candidal vaginitis in the last 6 months;

if the patient has a high body temperature (≥38 ° C), pain in the lower abdomen, dysuria, back pain, purulent vaginal discharge with an unpleasant odor, vulvar and vaginal ulcers, redness, diarrhea, nausea, vomiting, vaginal bleeding, accompanied by pain in the shoulder.