Decamevit 20 tablets — Made in Ukraine — Free Delivery

The preparation is not recommended to be prescribed together with other multivitamins, since an overdose of the latter in the body is possible.

High doses of the preparation reduce the effectiveness of tricyclic antidepressants, antipsychotics - phenothiazine derivatives, tubular reabsorption of amphetamine, and interfere with the excretion of mexiletine by the kidneys.

Due to the possibility of developing hypervitaminosis A, concomitant use of the preparation with other preparations containing vitamin A or with oral retinoids is not recommended.

Retinol reduces the anti-inflammatory effect of glucocorticoids. Cannot be used simultaneously with nitrites and cholestyramine, since they interfere with the absorption of retinol.

Medicines containing iron inhibit the effect of vitamin E. Vitamin E should not be used together with preparations of iron, silver, agents that have an alkaline medium (such as sodium bicarbonate, trisamine), indirect anticoagulants (such as dicoumarin, neodycoumarin). Alpha-tocopherol acetate enhances the action of steroidal and non-steroidal anti-inflammatory preparations (such as sodium diclofenac, ibuprofen, prednisolone).

Thiamine hydrochloride, influencing the polarization processes in the area of ​​neuromuscular synapses, can weaken the curariform effect of muscle relaxants.

Pyridoxine hydrochloride weakens the action of levodopa, prevents the occurrence or reduces the toxic manifestations of isoniazid and other anti-tuberculosis preparations.

When using short-acting sulfonamides with ascorbic acid, the risk of crystalluria increases. With simultaneous use, it enhances the effect of penicillin, increases the absorption of iron, reduces the effectiveness of heparin and indirect anticoagulants, enhances the absorption of aluminum (taken into account while treating with antacids containing aluminum). The absorption of ascorbic acid decreases with simultaneous use with oral contraceptives, the use of fruit or vegetable juices, and alkaline drinks. Ascorbic acid can be used only 2 hours after deferoxamine injection. Long-term use of high doses of ascorbic acid reduces the effectiveness of treatment with disulfiram. Ascorbic acid increases the total clearance of ethyl alcohol. Medicines of the quinolone series, calcium chloride, salicylates, tetracyclines, corticosteroids, with prolonged use, reduce the reserves of ascorbic acid in the body. Ascorbic acid increases urinary excretion of oxalates and increases the risk of crystalluria when treated with salicylates.

Riboflavin is incompatible with streptomycin and reduces the effectiveness of antibacterial preparations (oxytetracycline, doxycycline, erythromycin, tetracycline and lincomycin). The tricyclic antidepressants, imipramine and amitriptyline, inhibit the metabolism of riboflavin, especially in the tissues of the heart.

Folic acid reduces plasma concentrations of phenytoin with other antiepileptic preparations, in particular phenobarbital, which causes a mutual decrease in clinical efficacy.

Ethanol, cycloserine, glutethimide, and methotrexate can interfere with folate metabolism. The absorption of folic acid decreases with simultaneous use with analgesics, anticonvulsants, antacids, sulfonamides, antibiotics, cytostatics. A decrease or change in absorption can occur with the simultaneous use of cholestyramine and folic acid. Therefore, the preparation should be taken 1 hour before or 4–6 hours after taking cholestyramine. Cannot be used together with mineral acids, reducing agents, since folic acid is inactivated.