The following side effects include those associated with the administration of the drug Diclofenac sodium in conditions of short-term and long-term use.

From the blood and lymphatic system: very rarely - thrombocytopenia, leukopenia, anemia (including hemolytic and aplastic anemia), agranulocytosis.

From the side of the immune system: rarely - hypersensitivity, anaphylactic and anaphylactoid reactions (including hypotension); very rarely - angioedema (including facial edema).

Mental disorders: very rarely - disorientation, depression, insomnia, nightmares, irritability, and other mental disorders.

From the side of the nervous system: often - headache, dizziness; rarely - drowsiness, fatigue; very rarely - paresthesia, memory impairment, convulsions, anxiety, tremor, aseptic meningitis, taste disorder, stroke, frequency unknown - confusion, hallucinations, sensitivity disorders, general malaise.

On the part of the organs of vision: very rarely - visual impairment, blurred vision, diplopia; frequency unknown - optic neuritis.

On the part of the organs of hearing and the labyrinth: often - vertigo; very rarely - tinnitus, hearing impairment.

From the side of the heart: very rarely - palpitations, chest pain, heart failure, myocardial infarction.

From the side of the vascular system: very rarely - arterial hypertension, arterial hypotension, vasculitis.

Respiratory, thoracic and mediastinal disorders: rarely - asthma (including dyspnea), bronchospasm; very rarely - pneumonitis.

From the digestive system: often - nausea, vomiting, diarrhea, dyspepsia, abdominal pain, flatulence, anorexia; rarely - gastritis, gastrointestinal bleeding, vomiting with blood impurities, hemorrhagic diarrhea, melena, stomach or intestinal ulcer with bleeding, gastrointestinal stenosis with perforation (sometimes with a fatal outcome, especially in elderly patients); very rarely - colitis (including hemorrhagic colitis, ischemic colitis and exacerbation of ulcerative colitis or Crohn's disease), constipation, stomatitis (including ulcerative stomatitis), glossitis, disorders of the esophagus, intestinal membrane strictures, pancreatitis.

Hepatobiliary disorders: often - an increase in the level of transaminases, rarely - hepatitis, jaundice, liver function disorders; very rarely - instantaneous hepatitis, hepatonecrosis, liver failure.

From the side of the skin and subcutaneous tissues: often - a rash; rarely - urticaria; very rarely - bullous rashes, eczema, erythema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), exfoliative dermatitis, hair loss, photosensitivity reaction, purpura, allergic purpura, itching.

From the side of the kidneys and urinary tract: very rarely - acute kidney damage (acute renal failure), hematuria, proteinuria, nephrotic syndrome, interstitial nephritis, renal papillary necrosis.

General disorders and disorders at the injection site: often - a reaction at the injection site, pain, tightness; rarely - edema, necrosis at the injection site, very rarely - abscess at the injection site.

From the reproductive system and mammary glands: very rarely - impotence.

Data from clinical studies and epidemiological data indicate an increased risk of thrombotic complications (for example, myocardial infarction or stroke) associated with the use of diclofenac, in particular at high therapeutic doses (150 mg per day) and with long-term use.

Visual disturbances.

Visual disturbances such as blurred vision, visual impairment, and diplopia are side effects of the NSAID class and are usually reversible after discontinuation of the drug. The most likely mechanism of visual disturbances is suppression of the synthesis of prostaglandins and other related compounds, which, by disrupting the regulation of retinal blood flow, contribute to the development of visual disturbances. If such symptoms occur during treatment with diclofenac, an ophthalmological examination should be performed to rule out other possible causes.

Store in the original packaging at a temperature not higher than 25°C.

Keep out of the reach of children.

For 3 ml in ampoules. 5 ampoules in a pack with partitions or 5 ampoules in a one-sided blister, 1 blister in a pack; or 100 ampoules in a box with partitions.