Neuromax injection 2ml x 10 ampoules — Made in Ukraine — Free Delivery

The action of the preparation is due to the action of its active components.

The neurotropic B vitamins have a beneficial effect on inflammatory and degenerative diseases of the nerves and locomotor system. They are used to eliminate deficiency conditions, and in large doses they have an analgesic effect, improve blood circulation, normalize the functioning of the nervous system and the process of hematopoiesis.

Vitamin B 1 (thiamine) is a very important active ingredient. In the body, vitamin 1 is phosphorylated to form biologically active thiamine diphosphate (cocarboxylase) and thiamine triphosphate (TTP).

Thiamine diphosphate as a coenzyme takes part in the process of carbohydrate metabolism, which are of decisive importance in the metabolic processes of nervous tissue, affect the conduction of nerve impulses in synapses. With a deficiency of vitamin B 1 in the tissues, the accumulation of metabolites occurs, primarily lactic and pyruvic acid, which leads to various pathological conditions and disorders of the nervous system.

Vitamin B 6 (pyridoxine) in phosphorylated form (pyridoxal-5-phosphate, PALP) is a coenzyme of a number of enzymes that interact in the overall non-oxidative metabolism of amino acids. Through decarboxylation, they participate in the formation of physiologically active amines (adrenaline, histamine, serotonin, dopamine, tyramine), through transamination - to anabolic and catabolic metabolic processes (for example, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, γ-amino acid metabolism) also to various processes of cleavage and synthesis of amino acids. Vitamin B 6 acts on 4 different tryptophan metabolism. In the process of hemoglobin synthesis, vitamin B 6 catalyzes the formation of a-amino-b-ketoadinic acid.

Vitamin B 12 (cyanocobalamin) is essential for the processes of cellular metabolism. It affects the function of hematopoiesis (external antianemic factor), participates in the formation of choline, methionine, creatinine, nucleic acids, and has an analgesic effect.

Pharmacokinetics. After parenteral administration, thiamine is distributed in the body. Approximately 1 mg of thiamine is broken down daily. Metabolites are excreted in the urine. Dephosphorylation occurs in the kidneys. The biological half-life of thiamine is 0.35 hours. The accumulation of thiamine in the body does not occur due to the limited dissolution in fats.

Vitamin B 6 is phosphorylated and oxidized to pyridoxal 5-phosphate. In blood plasma, pyridoxal 5-phosphate and pyridoxal bind to albumin. The form transported is pyridoxal. For passage through the cell membrane, pyridoxal-5-phosphate bound to albumin is hydrolyzed by alkaline phosphatase to pyridoxal.

Vitamin B 12 after parenteral administration forms transport protein complexes that are rapidly absorbed by the liver, bone marrow and other proliferative organs. Vitamin B 12 enters bile and takes part in the intestinal-hepatic circulation. Vitamin B 12 passes through the placenta.

Neurological diseases of various origins: neuritis, neuralgia, polyneuropathy (diabetic, alcoholic), radicular syndrome, retrobulbar neuritis, facial nerve damage.

Hypersensitivity to the components of the preparation; acute violation of cardiac conduction; acute form of decompensated heart failure.

Vitamin B 1 is contraindicated in case of allergic reactions.

Vitamin B 6 is contraindicated for use in case of gastric ulcer and duodenal ulcer in the acute stage (since it is possible to increase the acidity of gastric juice).

Vitamin B 12 is contraindicated for use in erythremia, erythrocytosis, thromboembolism.

Lidocaine. Hypersensitivity to lidocaine or other amide local anesthetics, a history of epileptiform seizures to lidocaine, severe bradycardia, severe arterial hypotension, cardiogenic shock, severe forms of chronic heart failure (II-III degree), sick sinus syndrome, Wolf-Parkinson syndrome White, Adams-Stokes syndrome, AV (AV) blockade of II and III degrees, hypovolemia, severe liver / kidney dysfunction, porphyria, myasthenia gravis.