Duspatalin 135mg 15 tablets — Made in France — Free Delivery

(Duspatalin 135mg)
Duspatalin 135mg 15 tablets — Made in France — Free Delivery
Availability: In Stock
Mylan Laboratories Brand: Mylan Laboratories
Free Shipping! If your country is on the checkout list, we deliver to you.
Delivery Timeframes:
Europe: 7 to 18 business days
US and the Rest of the World: 9 to 20 business days

Description Duspatalin 135mg 15 tablets — Made in France — Free Delivery

Pharmacological properties

Pharmacodynamics

Mechanism of action and pharmacodynamic effects. Mebeverine is a myotropic antispasmodic with a selective effect on the smooth muscles of the digestive tract. It eliminates spasms without inhibiting normal intestinal motility. Since this action is not mediated by the autonomic nervous system, there are no typical anticholinergic side effects.

The clinical efficacy and safety of various dosage forms of mebeverine have been studied in more than 1,500 patients. Significant reductions in the predominant symptoms of irritable bowel syndrome (eg, abdominal pain, stool characteristics) have generally been observed in reference and pivotal-controlled clinical trials.

All dosage forms of mebeverine were generally safe and well tolerated at the recommended dosage regimen.

Children. Clinical studies of tablets or capsules have only been conducted in adults. Clinical efficacy and safety data from clinical trials, as well as post-marketing experience with the use of mebeverine pamoate suspension in patients aged 3 years and older, have demonstrated that mebeverine is an effective safe preparation, well tolerated.

Clinical studies of mebeverine suspension have shown that it is effective in relieving the symptoms of irritable bowel syndrome in children. Further open-label studies of mebeverine suspensions confirmed the efficacy of the preparation.

The dosage regimen of tablets or capsules is calculated based on the safety and tolerability of mebeverine.

Pharmacokinetics

Absorption. Mebeverine is rapidly and completely absorbed after oral administration in tablet form. Due to the prolonged release of the preparation from the capsule, it can be taken 2 times a day.

Distribution. With repeated use of Duspatalin, significant cumulation does not occur.

Metabolism. Meverine hydrochloride is mainly metabolized by esterases, which, at the first stage of metabolism, break down ester bonds to form veratric acid and mebeverine alcohol. In blood plasma, demethylcarboxylic acid (DMCA) is the main metabolite. T1 / 2 of DMCC in equilibrium state - 5.77 hours 97%.

Excretion. Mebeverine is not excreted unchanged, it is completely metabolized, and metabolites are excreted almost completely. Veratric acid is excreted in the urine. Mebeverine alcohol is also excreted by the kidneys in the form of the corresponding carboxyl or DMCA.

Children. Pharmacokinetic studies in children have not been conducted.

Indications

Adults and children over the age of 10:

  • symptomatic treatment of abdominal pain and spasms, impaired bowel function and intestinal discomfort in irritable bowel syndrome;
  • treatment of gastrointestinal spasms of secondary genesis caused by organic diseases.

Application

For oral administration. drink tablets or capsules with a sufficient amount of water (at least 100 ml). it is not recommended to chew due to the fact that the tablets have an unpleasant taste, and the capsule coating is intended to provide a prolonged release mechanism.

Adults and children over the age of 10 take 1 tablet 3 times a day about 20 minutes before meals or 1 capsule 2 times a day (morning and evening).

The duration of use is not limited. If one or more doses are missed, the patient should take the next dose as previously prescribed. The missed dose should not be taken in addition to the regular dose.

Special populations. Dosing studies in elderly patients, patients with impaired renal and / or hepatic function have not been conducted. Based on existing post-marketing data, no specific risk for the elderly has been identified in patients with impaired renal and / or liver function. There is no need for dose adjustment for the above patient groups.

Contraindications

Hypersensitivity to the active substance or any of the inactive components of the preparation.

Side effects

The following adverse reactions have been reported, occurring spontaneously during post-marketing use. the frequency cannot be accurately determined from the available data.

Allergic reactions were observed mainly from the skin.

Skin and subcutaneous tissue disorders: urticaria, angioedema, facial edema and rash.

From the immune system: hypersensitivity (anaphylactic reactions).

Special instructions

Use during pregnancy and lactation. there are only very limited data on the use of mebeverine in pregnant women. studies of reproductive toxicity in animals are insufficient. duspatalin is not recommended for use during pregnancy.

It is not known whether mebeverine or its metabolites passes into breast milk. The excretion of mebeverine into the breast milk of animals has not been studied. Duspatalin should not be used during breastfeeding.

There is no clinical data on the effect on male or female fertility; however, animal studies have not shown any harmful effects of Duspatalin.

Children. Duspatalin capsules should not be used in children under 3 years of age due to the lack of clinical data for this age category. Also, Duspatalin capsules should not be used in children aged 3 to 10 years due to the high content of the active substance.

The ability to influence the reaction rate when driving or working with other mechanisms. Studies of the effect on the ability to drive and operate machinery have not been conducted. The pharmacodynamic and pharmacokinetic profile, as well as post-marketing experience, do not indicate any harmful effect on the ability to drive a car and work with mechanisms.

Interactions

Interaction studies with alcohol have been conducted. in vitro and in vivo studies in animals have shown the absence of any interaction between duspatalin and ethanol.

Overdose

In case of an overdose, excitation of the central nervous system can theoretically be observed. in cases of mebeverine overdose, the symptoms were absent or they were mild and quickly disappeared. the observed overdose symptoms were of neurological or cardiovascular origin. the specific antidote is unknown. symptomatic treatment is recommended. gastric lavage is recommended only in case of intoxication with numerous preparations, which is diagnosed within 1 hour from the moment of taking the preparations. measures to reduce absorption are not necessary.

Storage conditions

In its original packaging at a temperature not exceeding 25 ° C. do not store at temperatures below 5 ° C.

Tags: Duspatalin

Reviews Duspatalin 135mg 15 tablets — Made in France — Free Delivery

User

I recommend

Lucyna

it helps!

S...O

very good

t...h

Effective

Write a review

Products viewed

Mezym 10000, 3p x 20 capsules — Made in Germany — Free Delivery

Mezym 10000, 3p x 20 capsules — Made in Germany — Free Delivery

Product descriptionMezym Capsules 10000 are indicated for violation of the exocrine function of the pancreas, accompanied by indigestion.StructureActive ingredient: powder from the pancreas (pigs);Mezym ® Capsules 10000: 1 solid capsule contains powder from the pancreas (pigs) 153.5 (..

$33.43

Neoflorum antidiarrheal combined probiotic 10 capsules — Made in Canada — Free Delivery

Neoflorum antidiarrheal combined probiotic 10 capsules — Made in Canada — Free Delivery

Product descriptionAntidiarrheal capsules combined probiotic Neoflorum (4 pcs per pack) is produced according to a unique Canadian technology, thanks to which a large number of lacto- and bifidobacteria, as well as Saccharomyces Boulardi, enter the intestines intact, having a beneficial effect on th..

$26.28

Butiner 500, 30 gastro-resistant tablets — Made in Poland — Free Delivery

Butiner 500, 30 gastro-resistant tablets — Made in Poland — Free Delivery

Product descriptionButiner 500 is a food for special medical purposes, containing butyric acid in the form of sodium butyrate. The preparation is intended for the dietary management of functional disorders of the intestines such as irritable bowel syndrome, inflammatory bowel diseases, including ulc..

$33.81

3 x HYLO-FRESH 10ML EYE DROPS - MADE IN GERMANY - FREE SHIPPING

3 x HYLO-FRESH 10ML EYE DROPS - MADE IN GERMANY - FREE SHIPPING

Application:conjunctival irritation, red and burning eyes, increased tear secretion, swelling and redness of eyelids or their edges.How to use: usually instilled 3 times a day, 1 drop of the preparation into the conjunctival sac of each eye. In the case of more intense ailments can be used more ofte..

$47.29

2 x VOLTAREN ACTI FORTE 25MG 20 TABS — MADE IN SWITZERLAND — FREE SHIPPING

2 x VOLTAREN ACTI FORTE 25MG 20 TABS — MADE IN SWITZERLAND — FREE SHIPPING

indications:Muscle pain, rheumatic pain, back pain, headache, toothache, menstrual pain. Flu and cold symptoms.Features:Voltaren Acti forte belongs to the group of non-steroidal anti-inflammatory preparations. It has an analgesic and anti-inflammatory effect, it also lowers fever.Voltaren® Acti fort..

$29.96

Buyers Online

AI Pharmacist • VEV.ICU

Online | Multilingual

v2.19
Hi! I am your AI assistant. Describe your problem, and I'll help you find the right medicine.
You can write to me in any language you prefer.
I don't answer technical questions (prices, delivery, payments).