Espa-Tibol 2.5mg 28 tablets — Made in Germany — Free Delivery
(Espa-Tibol )
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Description Espa-Tibol 2.5mg 28 tablets — Made in Germany — Free Delivery
Product description
Espa-tibol tablets are used to treat symptoms of estrogen deficiency in postmenopausal women if menopause has occurred more than 1 year ago.
The decision to prescribe tibolone should be based on an assessment of individual risk factors; when prescribing to patients over the age of 60, the risk of stroke should be taken into account.
Compound
The active substance is tibolone (one tablet contains tibolone 2.5 mg).
Excipients: potato starch, magnesium stearate, ascorbyl palmitate, lactose monohydrate.
Contraindications
- hypersensitivity to the active substance or to any of the excipients;
- pregnancy and lactation period;
- suspicion of breast cancer, its current or history (the preparation increased the risk of recurrence of breast cancer in a placebo-controlled study);
- suspected or existing estrogen-dependent tumors (eg endometrial cancer);
- vaginal bleeding of unknown etiology;
- untreated endometrial hyperplasia;
- venous thromboembolism in history or at present (deep vein thrombosis, pulmonary embolism);
- history of arterial thromboembolic diseases (for example, angina pectoris, myocardial infarction, stroke, or transient ischemic cerebrovascular accident);
- acute liver disease or a history of liver disease, until normalization of liver function tests;
- porphyria.
Mode of application
The recommended dose is one tablet per day. There is no need for dose adjustment for elderly patients. Take the tablets with a small amount of water or other drinks, preferably at the same time of day. To initiate and continue treatment for postmenopausal symptoms, the lowest effective dose should be used for the shortest period of time. When treating with Espatibol, progestogens should not be used separately.
The beginning of the use of the preparation "Espatibol". Women with natural menopause are advised to start treatment with Espatibol no earlier than 12 months after the last natural bleeding. In the case of menopause that occurred after surgery, treatment with Espatibol can be started immediately.
Before you start taking Espatibol, the cause of any irregular / unscheduled vaginal bleeding, including when using hormone replacement therapy (HRT), must be determined to exclude a malignant neoplasm.
Application features
Drivers
The preparation does not affect the reaction rate when driving vehicles or working with other mechanisms.
Overdose
The acute toxicity of tibolone in animals is very low. Therefore, the appearance of symptoms of toxicity is expected, even when taking several tablets at the same time. In acute overdose, a woman may experience nausea, vomiting, and vaginal bleeding. There is no specific antidote. If necessary, symptomatic therapy should be carried out.
Side effects
The following adverse reactions were reported during the 21st placebo-controlled study (including the LIFT studies), with the participation of 4079 women who received therapeutic doses of tibolone (1.25 or 2.5 mg), as well as 3476 women who received placebo. The duration of treatment in these studies ranged from 2 months to 4.5 years.
The following are the adverse reactions that occur in the treatment of tibolone significantly more often than when taking placebo.
From the gastrointestinal tract: often (> 1%, < 10%) - pain in the lower abdomen.
From the skin and subcutaneous tissue: often (> 1%, < 10%) - pathological hair growth.
From the reproductive system and mammary glands: often (> 1%, < 10%) - vaginal discharge, thickening of the walls of the endometrium, postmenopausal bleeding, discomfort in the mammary glands, itching of the genital organs, vaginal candidiasis, vaginal bleeding, pain in the pelvic area, cervical dysplasia, vulvovaginitis.
Examination: often (> 1%, < 10%) - weight gain, abnormal cervical smear results.
Storage conditions
Store at a temperature not exceeding 25 ° C, out of the reach of children.
Shelf life - 30 months.
Tags: Espa-Tibol
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