Exforge H 10mg/160mg/12.5mg 14 tablets — Made in Spain — Free Delivery
(Exforge H)
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Description Exforge H 10mg/160mg/12.5mg 14 tablets — Made in Spain — Free Delivery
Product description
Exforge H tablets are indicated for the treatment of essential hypertension in adult patients with blood pressure adequately controlled by a combination of amlodipine, valsartan and hydrochlorothiazide, who use three separate substances or two preparations, one of which is combined.
Compound
Active ingredients: amlodipine besilate, valsartan, hydrochlorothiazide;
1 tablet 5 mg / 160 mg / 12.5 mg contains amlodipine besilate 6.94 mg, which is equivalent to amlodipine base 5 mg, valsartan 160 mg and hydrochlorothiazide 12.5 mg;
1 tablet 10 mg / 160 mg / 12.5 mg contains amlodipine besylate 13.87 mg, which is equivalent to amlodipine base 10 mg, valsartan 160 mg and hydrochlorothiazide 12.5 mg;
1 tablet 5 mg / 160 mg / 25 mg contains amlodipine besylate 6.94 mg, which is equivalent to amlodipine base 5 mg, valsartan 160 mg and hydrochlorothiazide 25 mg;
1 tablet 10 mg / 160 mg / 25 mg contains amlodipine besilate 13.87 mg, which is equivalent to amlodipine base 10 mg, valsartan 160 mg and hydrochlorothiazide 25 mg;
Excipients: microcrystalline cellulose, crospovidone, colloidal silicon dioxide, magnesium stearate, hypromellose, titanium dioxide (E 171), macrogol 4000, talc, iron oxide yellow (E172) - only for tablets of 5 mg / 160 mg / 25 mg, 10 mg / 160 mg / 12.5 mg, 10 mg / 160 mg / 25 mg iron oxide red (E172) - only for tablets of 10 mg / 160 mg / 12.5 mg.
Contraindications
- hypersensitivity to the active substance, dihydropyridine derivatives or to any of the excipients of the preparation;
- severe liver dysfunction, biliary cirrhosis or cholestasis;
- simultaneous use of angiotensin receptor antagonists (ARA), including valsartan, or angiotensin-converting enzyme (ACE) inhibitors with aliskiren in patients with diabetes mellitus or with impaired renal function (GFR < 60 mg / minute / 1.73 m 2);
- pregnancy and pregnancy planning;
- severe hypotension;
- shock (including cardiogenic shock);
- obstruction of the outflow tract of the left ventricle (for example, hypertrophic obstructive cardiomyopathy and severe aortic stenosis);
- hemodynamically unstable heart failure after acute myocardial infarction.
Mode of application
Exforge H can be taken with or without food. Tablets should be swallowed whole with water at the same time of day, preferably in the morning.
Application features
pregnant
The preparation is contraindicated for pregnant women or women planning pregnancy.
Children
Not recommended for use in children.
Drivers
Patients who use Exforge H may experience dizziness or a feeling of weakness after taking the preparation, so they should take this into account when driving vehicles and when working with potentially dangerous mechanisms.
Overdose
There is still no experience of an overdose of Exforge H The main symptom of an overdose of valsartan is probably severe arterial hypotension with dizziness. An overdose of amlodipine can lead to progressive peripheral vasodilation and possibly reflex tachycardia. Significant and potentially prolonged systemic hypotension, up to shock and death, has been reported.
If the preparation has been taken recently, induce vomiting or gastric lavage. The absorption of amlodipine is significantly reduced when activated charcoal is used immediately or within two hours after taking amlodipine.
Side effects
The safety of Exforge H was evaluated in 5 controlled clinical trials involving 5175 patients, 2613 of whom received valsartan in combination with amlodipine. Adverse reactions that were observed most often or were significant or severe: nasopharyngitis, influenza, hypersensitivity, headache, syncope, orthostatic hypotension, edema, soft tissue edema, facial edema, peripheral edema, increased fatigue, facial flushing, asthenia and hot flashes.
Interaction
Aliskiren. In patients with diabetes mellitus or patients with impaired renal function, the risk of hyperkalemia, deterioration of renal function and cardiovascular morbidity and mortality is increased.
Medicines that cause hyperkalemia. Some preparations or therapeutic classes of preparations can cause hyperkalemia, namely: aliskiren, potassium salts, potassium-sparing diuretics, ACE inhibitors, angiotensin II receptor antagonists, non-steroidal anti-inflammatory preparations (NSAIDs), heparin, immunosuppressants such as cyclosporine or tacrolimus, trimethoprim. The simultaneous use of these preparations increases the risk of hyperkalemia.
Storage conditions
Store at a temperature not exceeding 30°C in a place protected from moisture.
Keep out of the reach of children.
Shelf life - 2 years.
Tags: Exforge
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