Exoderil cutaneous solution 1%, 10ml — Made in Germany — Free Deliver

Pharmacodynamics. Exoderil® is an antifungal agent of the allylamine class. its active ingredient is naftifine hydrochloride, the mechanism of action of which is associated with inhibition of the action of ergosterol.

Naftifine is active against dermatophytes such as trichophyton, epidermophyton and microsporum, yeast (Candida), mold (Aspergillus) and other fungi (eg Sporothrix Schenckii). With respect to dermatophytes and aspergillus, naftifine in vitro has a fungicidal effect, with respect to yeasts, it exhibits fungicidal or fungistatic activity, depending on the strain of the microorganism.

Exoderil® also exhibits antibacterial activity against gram-positive and gram-negative microorganisms, which can cause secondary bacterial infections along with mycotic lesions.

In addition, Exoderil has powerful anti-inflammatory properties.

Pharmacokinetics. Naftifine hydrochloride is rapidly absorbed and forms stable antifungal concentrations in different layers of the skin. Approximately 4% of the dose applied to the skin is absorbed, therefore the systemic effect of the active substance is very low. Only trace amounts of naftifine are detected in blood plasma and urine. The active substance is almost completely metabolized; metabolites have no antifungal activity and are excreted in feces and urine. Т½ is 2–4 days.

Local treatment for fungal infections caused by pathogens sensitive to naftifine:

Exoderil® should be applied to the affected skin surface and adjacent areas once a day after thorough cleansing and drying, capturing approximately 1 cm of healthy skin along the edges of the affected area.

Duration of treatment: with dermatomycosis - 2-4 weeks (if necessary - up to 8 weeks); with candidiasis - 4 weeks; for nail infections, it should be used 2 times a day with a duration of treatment up to 6 months.

Before the first use, it is necessary to remove the affected part of the nail as much as possible with scissors or a nail file (to facilitate this procedure, on the recommendation of a doctor, nails can be treated with a special softening agent).

To prevent relapse, preparation treatment must be continued for at least 2 weeks after the disappearance of the main symptoms of the disease.

Hypersensitivity to naftifine or preparation excipients. the preparation should not be applied to the wound surface. do not use to treat eyes.

The frequency of adverse reactions is defined as follows: very often (? 1/10), often (? 1/100, 1/10), infrequently (? 1/1000, 1/100), rarely (? 1/10 000, 1 / 1000), very rare (1/10 000), frequency unknown (cannot be calculated from the available data).

General disorders: the frequency is unknown - in isolated cases, local reactions may occur: dry skin, redness and burning, erythema, itching, local irritation.

The preparation is used for skin and nail diseases only externally!

The preparation in the form of a cutaneous solution contains ethanol, therefore contact of the solution in the eyes and on open wounds should be avoided. Solution contains propylene glycol, which may irritate the skin.

Use during pregnancy and lactation. Data on the use of naftifine in pregnant women are absent or limited. The results of animal studies do not indicate the existence of a direct or indirect harmful effect of the preparation on reproductive function. The preparation can be used during pregnancy and lactation only if absolutely necessary after a careful assessment of the benefit / risk ratio, which is determined by the doctor.

For women who are breastfeeding, it is necessary to prevent the preparation  from getting on the skin and into the digestive tract of the baby.

Children. There is insufficient data on the efficacy and safety of the preparation in children, therefore it is not recommended to prescribe Exoderil to patients of this age group.

The ability to influence the reaction rate when driving or working with other mechanisms. Does not affect.

Interaction studies have not been conducted.

Acute overdose with topical application of naftifine was not noted.

Systemic intoxication with external use of the preparation is unlikely due to the fact that a small amount of the active substance is absorbed through the skin.

If the preparation is accidentally swallowed, symptomatic treatment should be started.

At a temperature not higher than 30 ° C. after opening the bottle, store the solution for 6 months at a temperature not exceeding 25 ° C. Keep out of the reach of children.