Felodip 5mg 30 tablets — Made in Germany — Free Delivery

(Felodip 5mg )
Felodip 5mg 30 tablets — Made in Germany — Free Delivery
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Description Felodip 5mg 30 tablets — Made in Germany — Free Delivery

Indications

Arterial hypertension, stable angina (including Prinzmetal's angina)

Contraindications

Hypersensitivity to felodipine and other derivatives of the dihydropyridine series
Unstable angina
Acute myocardial infarction and within one month after myocardial infarction
Cardiogenic shock
Clinically significant aortic stenosis
Pregnancy and lactation
Chronic heart failure in the stage of decompensation
Severe arterial hypotension
Age up to 18 years (efficacy and safety not established)
Carefully
Hepatic and/or renal failure, aortic stenosis, BP lability and heart failure after myocardial infarction

Side effects

As with other slow calcium channel blockers, the preparation may cause facial flushing, headache, palpitations, dizziness, and increased fatigue.
These reactions are reversible and most often occur at the beginning of treatment or with an increase in the dose of the preparation. Also, depending on the dose, peripheral edema may appear, which are the result of precapillary vasodilation. Patients with gum disease or periodontitis may experience mild swelling of the gums. This can be prevented by good oral hygiene.
The frequency of side effects is determined according to the following definitions: often (1/100 or more), less often (1/1000-1/100), rare (1/10000-1/1000), very rare (less than 1/10000).
From the side of the cardiovascular system: often - "flushing" of blood to the skin of the face, accompanied by flushing of the face, swelling of the ankles; less often - tachycardia, palpitations; rarely - fainting; very rarely - extrasystole, a pronounced decrease in blood pressure, accompanied by reflex tachycardia and worsening of the course of angina pectoris, leukocytoclastic vasculitis.
From the nervous system: often - headache; less often - paresthesia, dizziness.
From the digestive system: less often - nausea, abdominal pain; rarely - vomiting; very rarely - increased activity of "liver" transaminases; rarely - hyperplasia of the gums, mucous membrane of the tongue, gingivitis.
From the musculoskeletal system: rarely - arthralgia, myalgia.
Allergic reactions: less often - skin rash, itching; rarely - urticaria; very rarely - angioedema of the lips or tongue, photosensitivity reaction.
From the urinary system: very rarely - often urination.
Other: less often - fatigue; rarely, impotence/sexual dysfunction; very rarely - fever, hyperglycemia.
On the part of the skin: rarely - urticaria and itching. In isolated cases, photosensitization reactions;
Causal relationship not established: chest pain, facial swelling, flu-like syndrome, decreased blood pressure, myocardial infarction, syncope, angina pectoris, arrhythmia, extrasystole, diarrhea, dry mouth, flatulence, gynecomastia, anemia, arthralgia, back pain, myalgia , pain in the upper and lower extremities, depression, insomnia, anxiety, nervousness, drowsiness, irritability, pharyngitis, shortness of breath, bronchitis, influenza, sinusitis, epistaxis, erythema, bruising, leukocytoclastic vasculitis, visual impairment, polyuria, dysuria.

Interaction

Felodipine increases the concentration of digoxin in the blood plasma, however, a change in the dosage of felodipine is not required.
Cytochrome P450 inhibitors (for example, cimetidine, erythromycin, itraconazole, ketoconazole) slow down the metabolism of felodipine in the liver, increasing the concentration of the preparation in blood plasma.
Inducers of microsomal enzymes (phenytoin, carbamazepine, rifampicin, barbiturates) lower the concentration of felodipine in blood plasma. Non-steroidal anti-inflammatory preparations do not weaken the hypotensive effect of felodipine.
The high degree of protein binding of felodipine does not affect the binding of the free fraction of other preparations (for example, warfarin). Do not use felodipine at the same time as grapefruit juice. Beta-blockers, verapamil, tricyclic antidepressants and diuretics increase the hypotensive effect of felodipine.
Cytochrome P450 inhibitors (cimetidine, erythromycin, ketoconazole, itraconazole, HIV protease inhibitors, grapefruit juice), slowing down the metabolism of the preparation in the liver, increase its plasma concentration: with itraconazole - felodipine AUC increases 8 times, Cmax - 6 times, with erythromycin - AUC and Cmax 2.5 times, with grapefruit juice - 2 times, respectively.
Microsomal oxidation inducers - phenytoin, carbamazepine, phenobarbital, rifampicin, St. John's wort herb tincture - reduce felodipine AUC by 93% and Cmax by 82%.
Increases the concentration of tacrolimus in the blood plasma when used together (it is recommended to control the concentration of tacrolimus in the blood plasma and possible dose adjustment).
Cyclosporine increases Cmax of felodipine by 150%, AUC by 60% (the effect of felodipine on the pharmacokinetic parameters of cyclosporine is minimal). Cimetidine increases the Cmax and AUC of felodipine by 55%.
How to take, course of administration and dosage
The preparation is best taken in the morning by mouth, before meals or after a light breakfast.
Film-coated tablets should not be crushed, divided or crushed.
Arterial hypertension
Adults (including the elderly):
The dosage is always determined individually. Therapy begins with a dose of 5 mg 1 time per day. If necessary, the dosage can be increased; The usual maintenance dose is 5-10 mg once daily. To determine the individual dose, it is best to use tablets containing felodipine 2.5 mg. In the elderly or patients with impaired liver function, the recommended initial dosage is 2.5 mg 1 time per day.
stable angina
Adults:
The dosage is always determined individually. Treatment begins with a dose of 5 mg 1 time per day, if necessary, you can increase the dose to 10 mg 1 time per day. The maximum daily dose is 20 mg once a day.
Felodip may be used in combination with beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, or diuretics.
Combination therapy usually enhances the antihypertensive effect of the preparation.
It is necessary to beware of the development of arterial hypotension. In patients with severe hepatic impairment, the therapeutic dose should be reduced.
In patients with impaired renal function, the pharmacokinetics of the preparation does not change significantly.

Overdose

Symptoms: pronounced decrease in blood pressure, bradycardia.
Treatment: carry out symptomatic therapy. With a pronounced decrease in blood pressure, the patient should be given a horizontal position, legs should be raised. With the development of bradycardia, intravenous administration of atropine at a dose of 0.5-1.0 mg is indicated.
If this is not enough, it is necessary to increase the volume of blood plasma by infusion of a solution of dextrose (glucose), sodium chloride or dextran. If the above measures are ineffective, symptomatic preparations with a predominant effect on alpha-adrenergic receptors are prescribed.

Special Instructions

Felodip, as well as other vasodilators, in rare cases can cause significant arterial hypotension, which in a number of predisposed patients can lead to the development of myocardial ischemia. Currently, there is no data on the advisability of using the preparation as a secondary prevention of myocardial infarction.
Felodipine is effective and well tolerated by patients regardless of gender and age, as well as patients with concomitant diseases such as bronchial asthma and other lung diseases; impaired renal function; diabetes; gout; hyperlipidemia; Raynaud's syndrome, as well as after lung transplantation.
Felodipine does not affect the concentration of glucose in the blood and the lipid profile.
Influence on the ability to drive vehicles and control mechanisms:
patients who experience weakness, dizziness during treatment with felodipine should stop driving vehicles and work that requires increased attention and concentration.
Release form
Long-acting film-coated tablets

Storage conditions

In a dry, dark place at a temperature not exceeding 25°C.
Keep out of the reach of children.

Tags: Felodip

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