Flutafarm 250mg 50 tablets — Made in Ukraine — Free Delivery

Patients should be under constant medical supervision. special attention should be paid to the effect of the preparation  on liver function and spermatogenesis in patients who have not undergone orchiectomy (surgical or medical).

Treatment with the preparation should not be started if the levels of hepatic transaminases in the blood plasma are 2-3 times higher than the upper limit of the norm. Monitoring of liver function should be carried out during the entire period of preparation treatment. Plasma transaminase levels should be determined before starting flutamide therapy, monthly during the first 4 months of taking the preparation, periodically thereafter and at the first symptoms of liver dysfunction (for example, itching, dark urine, nausea, vomiting, fatigue, anorexia, jaundice, pain in right hypochondrium or incomprehensible flu-like symptoms). If jaundice appears or the activity of hepatic transaminases is 2-3 times higher than normal (in the absence of liver metastases, confirmed by biopsy), flutamide should be stopped immediately and liver function should be carefully monitored until the situation is clarified.

Patients should see a doctor immediately when the first symptoms of liver dysfunction appear, such as pruritus, dark urine, nausea, vomiting, persistent anorexia, yellowing of the sclera and skin, tenderness in the right hypochondrium, and flu-like symptoms.

Liver damage is usually reversible after discontinuation of therapy, and in some patients even after dose reduction.

Flutamide is excreted mainly by the kidneys; therefore, dose adjustment may be required in patients with renal insufficiency.

Since plasma levels of testosterone and estradiol increase during treatment with flutamide, fluid retention in body tissues is possible. Therefore, flutamide should be used with caution in patients with heart disease. In addition, an increase in estradiol levels may increase the risk of thromboembolism.

In patients without orchiectomy who have been treated with flutamide for a long time, it is necessary to periodically determine the sperm count.

Patients with latent or actual glucose-6-phosphate deficiency may develop methemoglobinemia. In the event of cyanosis, methemoglobinemia, the possible factor of excess dose should be taken into account.

Flutamide contains lactose, so patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not take the preparation.

When combined therapy with Flutapharm and an LHRH agonist, the possible side effects of each preparation must be taken into account.

Patients should be informed that flutamide and medicinal products intended for medical castration must be used in combination and that they should not be discontinued or the dose changed without first consulting a doctor.

Before using Flutapharma, women need to exclude organic hyperandrogenism (tumors of the ovaries and adrenal cortex).

Alcohol should not be consumed during treatment.

The ability to influence the reaction rate when driving or working with other mechanisms. Until the individual patient's response to the preparation is clarified, one should refrain from driving vehicles or other mechanisms, given that during treatment with flutamide, increased fatigue, sometimes dizziness, drowsiness and visual disturbances were observed.

Use during pregnancy and lactation. When using the preparation, women should pay special attention to preventing pregnancy with the help of non-hormonal, in particular barrier, contraceptives. In case of a positive pregnancy test, the preparation should be stopped immediately. Sexual intercourse with the aim of the desired pregnancy can be resumed no earlier than 48 hours after the last dose of Flutapharma.

Children. The preparation should not be used to treat children.

In patients receiving warfarin for a long time, after the start of monotherapy with flutamide, an increase in prothrombin time is observed. therefore, the combined use of flutapharm and warfarin requires careful monitoring of prothrombin time and, possibly, correction of anticoagulant doses.

Flutamide can slow down the metabolism of GCS.

Avoid the concomitant use of flutamide with potentially hepatotoxic preparations.

When flutamide is used simultaneously with theophylline, an increase in the concentration of theophylline in blood plasma is possible.

Excessive alcohol consumption should be avoided during treatment with flutamide.

A single dose of flutamide that would cause overdose symptoms or be life-threatening has not been established.

In case of overdose, dialysis is ineffective, given the high degree of binding of flutamide to blood plasma proteins.