Gamalate B6 20 tablets — Made in Spain — Free Delivery

Pharmacodynamics. Gamalate B6 contains a combination of active substances: gamk, amino-β-hydroxybutyric acid, vitamin B6 (pyridoxine hydrochloride), which are natural components of brain tissue, and magnesium glutamate hydrobromide (MGG). the preparation has a neuroregulatory effect on the processes in the brain, causes mild sedative and cerebrotonic effects.

GABA is formed in the brain by decarboxylation of glutamic acid. This reaction is catalyzed by the enzyme glutamine decarboxylase (GDC) and the coenzyme vitamin B6. As a result of the reaction, amino-β-hydroxybutyric acid (HABOM) is formed. GABOM has an anticonvulsant effect, which is realized through a cholinergic mechanism, improves memory and learning ability.

In addition, GABA can be converted back to its precursor (glutamic acid) through a transamination mechanism catalyzed by the enzyme GABA-α-ketoglutarate transaminase (GABA-T), vitamin B6 also acts as a coenzyme. Through this transamination mechanism, GABA is involved in brain oxygenation.

GABA is converted to glutamic acid, which is converted to aspartic acid, which forms the substrate for the Krebs cycle in the brain.

Thus, the level of GABA in the CNS depends on the balance of the enzymes HDA and GABA-T.

When the brain function is disturbed, an inhibition deficit occurs, which is associated with a decrease in the level of GABA, the main inhibitory neurotransmitter. Taking Gamalate B6 provides an exogenous supply of GABA to the nervous system, and a high level of GABA, in turn, provides the following effects:

MGG in its structure contains glutamic acid and a magnesium compound with bromine in the form of a chelate. Thanks to the latter, MGG acts as a partial (partial) agonist of L-glutamate and causes a decrease in stimulation and mild sedation. This distinguishes it from tranquilizers (benzodiazepines, barbiturates) with a direct inhibitory effect, which is associated with a high level of side effects that are not typical for MGH. Studies have shown the anticonvulsant activity of MGG, a positive effect on sleep disorders, neurovegetative changes and behavioral disorders in children. The calming effect of MGG is not associated with a decrease in attention and concentration.

Pharmacokinetics. Gamalate B6 contains 4 components, 3 of which are physiological products (GABA, GABOB and vitamin B6). Classical pharmacokinetic studies in this case cannot be carried out due to the difficulty of quantifying exogenous and endogenous components. Such a number of preparation components also makes it impossible to conduct an analysis using a radioactively labeled product due to a large radiological load.

It is prescribed for adults as an adjuvant for functional asthenia with manifestations:

Applied in adults inside 2 tablets 2-3 times a day.

The duration of treatment depends on the patient's condition and the course of the disease and is 2–18 months.

Hypersensitivity to the components of the preparation.