Glutargin solution for injection 400 mg/ml, 5ml x 10 ampoules — Made in Ukraine — Free Delivery

Pharmacological properties

Pharmacodynamics. Glutargin is a compound of arginine and glutamic acid, which play an important role in providing biochemical processes of neutralization and excretion from the body of a highly toxic metabolite of the exchange of nitrogen-containing substances - ammonia. the hypo-ammonia effect of the preparation is realized as a result of the activation of the processes of neutralization of ammonia in the ornithine cycle of urea synthesis, the binding of ammonia to non-toxic glutamine, as well as an increase in the excretion of ammonia from the central nervous system and its excretion from the body. due to these properties, glutargin reduces the general toxic and neurotoxic effects of ammonia.

Glutargin also has a hepatoprotective effect, has antioxidant, antihypoxic and membrane-stabilizing activity, positively affecting the energy supply of hepatocytes.

In case of alcohol intoxication, Glutargin stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme of ethanol utilization - alcohol dehydrogenase; accelerates the inactivation and elimination of toxic products of ethanol metabolism as a result of an increase in the formation and oxidation of succinic acid; reduces the depressing effect of alcohol on the central nervous system due to the neurotransmitter properties of glutamic acid. Thanks to these properties, Glutargin exhibits antitoxic and sobering effects.

In pathology of pregnancy, thanks to its endothelium-protective effect, Glutargin normalizes impaired vascular permeability and thromboresistance, prevents hypercoagulation, reduces the sensitivity of vessels to vasoconstrictor agents (endothelin, angiotensin, thromboxane), which cause generalized vasospasm. Arginine, after preliminary biotransformation into nitric oxide, has a vasodilating effect, has a positive effect on blood coagulation and the functional properties of circulating blood elements. As a result of the vasodilating and antihypoxic effects of Glutargin, maternal-fetal hemodynamics improves, and intrauterine fetal hypoxia decreases. In the pathology of pregnancy, the preparation also exhibits antitoxic and hepatoprotective activity, acts as a nonspecific metabolic regulator of metabolic processes. Due to these properties of Glutargin during pregnancy, the level of immune complexes circulating in the blood decreases, the severity of the syndrome of metabolic intoxication and immunotoxicosis decreases, and the compensatory-adaptive reactions of the body increase.

Glutargin does not have embryotoxic, gonadotoxic, mutagenic and teratogenic effects, does not cause allergic and immunotoxic reactions.

Pharmacokinetics have not been studied.

Indications

As part of the complex therapy of acute and chronic hepatitis of various etiologies, poisoning with hepatotropic poisons (the poison of the pale grebe, chemicals and preparations), with cirrhosis of the liver, liver damage with leptospirosis. hepatic encephalopathy, precoma and coma, accompanied by hyperammonemia.

A state of acute alcoholic intoxication of mild and moderate severity, as well as in the complex therapy of post-intoxication disorders after severe acute alcohol poisoning, including alcoholic encephalopathy and coma. Prevention of alcohol intoxication and hepatotoxic effects.

Post-intoxication disorders, hangover syndrome caused by alcohol use.

Complications in the third trimester of pregnancy: late gestosis, including its severe forms - preeclampsia and eclampsia, placental insufficiency, chronic pathologies of the hepatobiliary system in pregnant women.

Application

Hepatitis, hyperammonemia.

Pills. Orally administered to adults 3 tablets of 0.25 g (0.75) or 1 tablet of 0.75 3 times a day for 15 days, regardless of food intake. If necessary, the dose of the preparation  and the course of treatment can be extended up to 20 days. The maximum single dose is 2 g, the maximum daily dose is 8 g.

Solution for injection (4%). The preparation is prescribed for adults IV. Introduce intravenously drip 2 times a day, 50 ml (2 g) in 150–250 ml of isotonic sodium chloride solution at a rate of 60–70 drops per minute. In severe cases, the daily dose of the preparation is increased to 150-200 ml (6-8 g). The course of treatment is 5-10 days. The maximum daily dose is 200 ml (8 g).

Solution for injection (20%). The preparation is prescribed for adults intravenously and intramuscularly. Introduce intravenously drip 1-2 times a day, 10 ml (2 g) per 150-250 ml of isotonic sodium chloride solution or 5% glucose solution at a rate of 60-70 drops per minute. In severe cases, the daily dose of the preparation is increased to 30-40 ml (6-8 g), divided into 2 doses. The course of treatment is 5-10 days. The maximum daily dose for intravenous administration is 40 ml (8 g).

In / m the preparation is injected slowly deep into the sciatic muscle 1-2 times a day, 5 ml (1 g). If necessary, the dose of the preparation is increased to 10 ml (2 g) 1-2 times a day. The course of treatment is 5-10 days. The maximum daily dose for intramuscular injection is 20 ml of the preparation (4 g).

Concentrate for preparation of solution for infusion

Alcohol poisoning.

Pills. Prescribe 4 tablets of 0.25 g (1.0 g) or 1 g 4 times a day with an interval of 1-2.5 hours, in the next 2-3 days - 2 tablets of 0.25 g (0.5 d) or ½ 1 g 3 times a day. In case of severe alcohol intoxication, after a course of treatment with Glutargin injections, Glutargin tablets are prescribed 3 tablets of 0.25 g (0.75 g) or 1 tablet of 0.75 g 2 times a day, or 11/2 tablets of 1 g 1 time per day for 20 days. For the prevention of alcohol intoxication - 2 g 60–120 minutes before drinking.

Powder for oral solution

The preparation is prescribed for adults inside, after dissolving the package in ¼ – ½ glasses of water.

For the prevention of intoxication and the hepatotoxic effect of alcohol, 2 g (2 packets) are prescribed 1-2 hours before drinking alcohol or 1 g (1 packet) 1 hour before drinking alcohol and 1 g (1 packet) for 0.5 hours after drinking alcohol. For the treatment of acute alcohol intoxication of mild and moderate severity, 1 g (1 packet) is prescribed 4 times a day at intervals of 1-2.5 hours, in the next 2-3 days - 1 g (1 packet) 2 times a day. In case of severe alcohol intoxication, Glutargin alkocline powder is prescribed 1 g (1 sachet) 2 times a day for 20 days as part of complex therapy after a course of treatment with injectable forms of Glutargin.

Solution for injection (4%). For the treatment of alcohol intoxication, 20 ml (0.8 g) are prescribed, injected drip into 150-250 ml of isotonic sodium chloride solution at a rate of 60-70 drops per minute 2 times a day for 2-3 days, then the dose reduced to 10 ml (0.4 g) 2 times a day for 10 days. In severe cases (alcoholic coma), the daily dose is increased to 50 ml (2 g) 2 times a day.

After a course of treatment with Glutargin injection / infusion solution, if necessary, you should switch to taking Glutargin tablets.

Solution for injection (20%). The preparation is prescribed for adults intravenously and intramuscularly. Introduce intravenously drip 2 times a day, 4 ml (0.8 g) per 150–250 ml of isotonic sodium chloride solution or 5% glucose solution at a rate of 60–70 drops per minute. After 2-3 days, the dose is reduced to 2 ml (0.4 g).

The intramuscular preparation is injected slowly deep into the sciatic muscle, 4 ml (0.8 g) 2 times a day for 2-3 days, then the dose is reduced to 2 ml (0.4 g) 2 times a day for 5– 10 days. In severe cases (alcoholic coma), the daily dose of intravenous or intramuscular injection is increased to 10 ml (2 g) 2 times a day.

Concentrate for preparation of solution for infusion

For the treatment of alcohol poisoning, 2 ml (0.8 g) intravenous administration is prescribed, injected drip into 150-250 ml of isotonic sodium chloride solution at a rate of 60-70 drops per minute 2 times a day for 2-3 days , then the dose is reduced to 1 ml (0.4 g) 2 times a day for 10 days. In severe cases (alcoholic coma), the daily dose is increased to 5 ml (2 g) 2 times a day.

After a course of treatment with 40% Glutargin solution, if necessary, you should switch to taking Glutargin tablets.

Pregnancy pathologies

Pills. Prescribe 0.25-0.5 g (1-2 tablets of 0.25 g) 2-3 times a day for 10-15 days. If necessary, a single dose of the preparation can be increased to 0.75 g (3 tablets of 0.25 g or 1 tablet of 0.75 g), the course of treatment is up to 20 days. The highest single dose is 0.75 g, the highest daily dose is 2.25 g.

Solution for injection (4%). Enter 1–2 times a day, 50 ml (2 g each). The course of treatment is 5-7 days. The highest daily dose is 100 ml (4 g).

Concentrate for the preparation of a solution for infusion. Introduce dropwise 1–2 times a day, 5 ml (2 g) per 150–250 ml of isotonic sodium chloride solution at a rate of 60–70 drops per minute. The course of treatment is 5-7 days. The maximum daily dose is 10 ml (4 g).

Contraindications

Relative contraindications are febrile conditions, increased excitability, severe violations of the filtration (nitrogen excretion) function of the kidneys.

Side effects

Tablets: rarely - a feeling of slight discomfort in the stomach and intestines, nausea immediately after taking the preparation, self-limiting.

Solution for injections / infusions: rarely possible - severe weakness, shortness of breath, chest pain, chills, heart rhythm disturbances in the form of atrial fibrillation, hypotension, Quincke's edema. In isolated cases, mild allergic reactions (urticaria, hyperemia, itching).

Special instructions

When prescribing to patients with dysfunction of the endocrine glands, it should be borne in mind that the preparation is able to stimulate the secretion of insulin and growth hormone.

Children. The experience of using the preparation  in children is insufficient.

Influence on the ability to drive vehicles and work with complex mechanisms.

Tablets: no effect.

Rr: since during treatment, side reactions from the central nervous system (headache, dizziness, tremor) may occur, care should be taken when driving or working with other mechanisms.

Interactions

With simultaneous use with aminophylline, an increase in the concentration of endogenous insulin in the blood is possible. glutargin can enhance the effect of antiaggregatory agents (dipyridamole, etc.). prevents and reduces the severity of neurotoxic phenomena that may occur with the use of isoniazid. reduces the effect of vinblastine.

Overdose

Symptoms: chest pain, av block.

Treatment: in this case, intravenous administration of corticosteroids is indicated. Symptomatic therapy.

Storage conditions

Tablets in their original packaging at a temperature not exceeding 25 ° C, solution for injections. in original packaging at 25 ° C, conc. d / inf. solution in a dark place at a temperature of 25 ° C.

The preparation is prescribed for adults in / in the form of infusion. Introduce intravenously drip 2 times a day, 5 ml (2 g) in 150–250 ml of isotonic sodium chloride solution at a rate of 60–70 drops per minute. In severe cases, the daily dose of the preparation is increased to 15–20 ml (6–8 g). The course of treatment is 5-10 days. The maximum daily dose is 20 ml (8 g).