Indapamide 2.5mg 2p x 30 tablets — Made in Serbia — Free Delivery

Pharmacological properties

Indapamide ((rs) - 4-chloro-3-sulfamol-n- (2-methyl-2,3 dihydro-1n-indol-1-yl) benzamide) is a diuretic, antihypertensive agent of the non-thiazide sulfonamide group. indapamide causes a decrease in the tone of the smooth muscles of the arteries due to a change in the transmembrane current of calcium ions, a decrease in the sensitivity of the vascular wall to norepinephrine and angiotensin, which leads to a decrease in opss. indapamide stimulates the synthesis of prostaglandin e2, which has a vasodilating and hypotensive effect. exhibits a moderately pronounced diuretic effect, which is associated with blocking the reabsorption of sodium, chlorine, water and, to a lesser extent, potassium and magnesium ions. indapamide does not disrupt lipid metabolism and does not have a negative effect on carbohydrate metabolism, does not affect the level of total CS and Tg, and reduces the level of phosphates in the blood serum. the therapeutic effect develops after 7–8 days, the maximum effect - after 4 weeks.

After oral administration, indapamide is rapidly absorbed, the maximum concentration in the blood serum is reached after 2–2.5 hours and is 230–260 ng / ml. Approximately 71–79% of indapamide binds to blood plasma proteins, mainly to α1-glycoprotein. It is widely distributed in body tissues. The half-life is 14 hours. It is metabolized in the liver. It is excreted in the urine (7% - unchanged for 48 hours, 70% - in the form of metabolites) and in the bile (about 23%).

Indications

Ar of mild to moderate severity.

Application

Adults - 2.5 mg once a day, preferably in the morning. in case of insufficient hypotensive effect, the dose is increased to 5 mg per day (in one dose in the morning). increasing the dose of the preparation enhances the diuretic effect.

Contraindications

Hypersensitivity to indapamide and other components of the preparation, as well as to sulfonamides, acute cerebrovascular accidents, hyperaldosteronism, severe liver and kidney dysfunctions, hypokalemia.

Side effects

Headache, increased fatigue, convulsions, diarrhea, skin rash, frequent urination, in rare cases - orthostatic hypotension.

special instructions

With extreme caution, appoint patients with impaired liver and kidney function. in the course of treatment with the preparation, periodic monitoring of the level of electrolytes in the blood serum is necessary due to the possibility of hypokalemia and disturbances in the water-electrolyte balance. patients with hyperuricemia and gout, who are using indapamide, need periodic monitoring of the level of uric acid in the blood serum.

During treatment with the preparation, clinical manifestations of latent diabetes mellitus are possible, as well as a change in the need for insulin. By lowering blood pressure, the preparation can affect the ability to drive vehicles and mechanisms. Indapamide should not be prescribed during pregnancy and lactation.

Interactions

Potentiation of the action of other antihypertensive agents is possible when used simultaneously with indapamide. not prescribed simultaneously with lithium preparations, since this increases the risk of developing toxic effects of the latter (due to a decrease in renal clearance of lithium and an increase in its concentration in blood plasma). indapamide may reduce the effectiveness of norepinephrine. do not prescribe indapamide with potassium-sparing (spironolactone, amiloride, triamterene) diuretics. the simultaneous use of potassium-sparing diuretics does not exclude the possibility of hypokalemia.

Overdose

Possible nausea, vomiting, weakness, dysfunction of the digestive tract, disturbances in water and electrolyte balance, in severe cases - arterial hypotension and respiratory depression. there are no specific antidotes. carry out gastric lavage, correction of water and electrolyte balance.

Storage conditions

In a dry, dark place at a temperature of 15-25 ° C.