Isoprinosine 500mg 50 tablets — Made in Hungary — Free Delivery
(Isoprinosine )
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Description Isoprinosine 500mg 50 tablets — Made in Hungary — Free Delivery
Pharmacological properties
Pharmacodynamics. Isoprinosine is an antiviral agent with immunomodulatory properties. the preparation normalizes (to the individual norm) deficiency or dysfunction of cellular immunity, inducing the maturation and differentiation of t-lymphocytes and t1-helpers, potentiating the induction of a lymphoproliferative response in mitogenic or antigenic cells. isoprinosine simulates the cytotoxicity of T-lymphocytes and natural killer cells, the function of T8-suppressors and T4-helpers, and also increases the amount of immunoglobulin g and complement surface markers. isoprinosine increases the synthesis of interleukin (IL) -1 and IL-2, regulates the expression of IL-2 receptors. isoprinosine significantly increases the secretion of endogenous γ-interferon and reduces the production of IL-4 in the body. isoprinosine enhances the action of neutrophilic granulocytes, chemotaxis and phagocytosis of monocytes and macrophages. isoprinosine inhibits the synthesis of the virus by incorporating inosinorotic acid into the polyribosomes of the cell affected by the virus and inhibiting the attachment of adenylic acid to the viral irna.
Pharmacokinetics. After oral administration in a dose of 1.5 g, Cmax of inosine pranobex in blood plasma is reached after 1 hour and is 600 μg / ml. In the body, inosine pranobex is metabolized in the liver to form uric acid. T1 / 2 of 4- (acetylamino) benzoate is 50 minutes, 1- (dimethylamino) -2-propanol - 3.5 hours. It is excreted by the kidneys in the form of metabolites.
Indications
Viral infections caused by herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-barr virus, measles virus, mumps virus, including in patients with immunodeficiency states; viral respiratory infections; papillomavirus infections of the skin and mucous membranes: genital warts, papillomavirus infection of the vulva, vagina and cervix (as part of complex therapy); acute viral encephalitis (as part of complex therapy); viral hepatitis (as part of complex therapy); subacute sclerosing panencephalitis (as part of complex therapy).
Application
The preparation is administered orally. the daily dose depends on the body weight, the course and severity of the disease, the patient's condition.
Adults and children over the age of 12 years: 50 mg / kg body weight (6-8 tablets, divided into 3-4 doses), the maximum daily dose is 4 g.
Children aged 1 to 12 years: 50 mg / kg body weight (1 tablet per 10 kg body weight for a child weighing 10–20 kg, with a body weight of 20 kg, prescribe a dose as for adults), divided into 3 –4 doses per day, the maximum daily dose is 4 g. To facilitate swallowing, the tablet can be crushed.
Duration of treatment
Acute diseases: for diseases with a short-term course of treatment is from 5 to 14 days. After a decrease in the severity of the symptoms of the disease, treatment should be continued for another 1-2 days or longer, depending on the course of the disease and the patient's condition.
Long-term viral diseases: treatment should be continued for 1–2 weeks after the severity of the symptoms of the disease or longer, depending on the course of the disease and the patient's condition.
Recurrent diseases: At the initial stage of treatment, the same recommendations apply as for acute diseases. During maintenance therapy, the dose can be reduced to 500-1000 mg (1-2 tablets) per day. When the first signs of relapse appear, it is necessary to resume taking the daily dose recommended for acute diseases, and continue using it for 1-2 days after the symptoms disappear. The course of treatment can be repeated several times if necessary and depending on the patient's condition on the recommendation of a doctor.
Chronic diseases: apply the preparation in a daily dose of 50 mg / kg body weight according to the following schemes:
asymptomatic diseases - take within 30 days with a break of 60 days;
diseases with moderate symptoms - take within 60 days with a break of 30 days;
diseases with severe symptoms - apply for 90 days with a break of 30 days.
If necessary, the course of treatment should be repeated under the supervision of a physician, while constant monitoring of the patient's condition and the course of the disease should be carried out in order to continue therapy.
For infections caused by the human papillomavirus (external genital warts (genital warts) or papillomavirus infection of the cervical canal), take 3 g (2 tablets 3 times a day) for 14-28 days as monotherapy or as an addition to local therapy or surgical treatment according to the following schemes:
a) for the treatment of low-risk patients (patients with normal immunity or patients with a low risk of relapse), the preparation is used for 14-28 days until the maximum eradication of the virus is achieved, then a break should be taken for 2 months. The course of treatment can be repeated using the same dose, while constant monitoring of the patient's condition and the course of the disease is required to prolong therapy;
b) for the treatment of high-risk patients * (patients with immunodeficiency or with a high risk of relapse), the preparation is used 5 days a week, consecutively 1-2 weeks a month for 3 months. If necessary, the course of treatment should be repeated, while constant monitoring of the patient's condition and the course of the disease is required to prolong therapy.
* High risk factors in patients with recurrent or cervical dysplasia or genital papillomavirus infection, as in other similar diseases, include:
- immunodeficiency caused by a history of chronic or recurrent infections or sexually transmitted diseases; chemotherapy; chronic alcoholism;
- long-term use of oral contraceptives (≥2 years);
- the level of folate in erythrocytes is 660 nmol / l;
- multiple sexual partners or change of permanent sexual partner;
- frequent vaginal intercourse (≥2–6 times a week) or anal sex;
- atopy (hereditary predisposition to hypersensitivity);
- poorly controlled diabetes;
- smoking;
- papillomavirus infection of the genitals that lasts 2 years or has a history of ≥3 recurrences;
- negative history of childhood skin warts.
In subacute sclerosing panencephalitis, the daily dose is 100 mg / kg of body weight, the maximum dose is 3-4 g / day, while constant monitoring of the patient's condition and indications for prolongation of therapy is required.
Contraindications
Hypersensitivity to the active substance or any component of the preparation, exacerbation of gout, hyperuricemia.
Side effects
The only side effect that most often occurs during treatment with isoprinosine in both adults and children is a temporary increase in the level of uric acid in the blood plasma and urine (usually the level is within normal limits and returns to baseline values a few days after the end of treatment).
From the immune system: angioedema, hypersensitivity, urticaria, anaphylactic reactions.
Mental disorders: nervousness.
From the nervous system: headache, vertigo, drowsiness, insomnia, dizziness.
From the gastrointestinal tract: nausea, vomiting, discomfort in the epigastric region, diarrhea, constipation, abdominal pain (in the upper abdomen).
On the part of the skin and subcutaneous tissue: rash, itching, erythema.
On the part of the musculoskeletal system and connective tissue: arthralgia.
On the part of the kidneys and urinary system: polyuria.
General disorders and conditions: fatigue, malaise.
Laboratory data: increased levels of uric acid in the blood and urine; an increase in the level of urea, transaminases, alkaline phosphatase in the blood.
special instructions
During treatment with isoprinosine, a temporary increase in the level of uric acid in blood plasma and urine is possible, especially in men and the elderly, however, these indicators usually remain within the normal range (up to 8 mg / ml in blood plasma).
The reason for the increase in uric acid levels is the catabolic metabolism of inosine in humans. This is not due to a preparation-induced fundamental change in enzyme function or renal clearance function. Therefore, the preparation should be used with extreme caution in patients with gout, hyperuricemia, urolithiasis and reduced renal function. During treatment, it is necessary to monitor the level of uric acid in these patients. Some patients may experience acute hypersensitivity reactions (angioedema, anaphylactic shock, urticaria). In this case, Isoprinosine therapy should be discontinued.
With prolonged use of the preparation, there is a risk of developing nephrolithiasis.
Isoprinosine contains wheat starch, which may contain gluten, but in extremely small quantities, so the preparation is considered safe for people with celiac disease (celiac disease). Wheat allergy patients (as opposed to celiac disease) should not take this preparation.
Isoprinosine contains mannitol, which can have a laxative effect.
Use during pregnancy and lactation. The study of the possible risk of fetal pathologies and impaired fertility in humans has not been conducted. It is not known whether inosine pranobex passes into breast milk. It is not recommended to use the preparation during pregnancy and lactation.
Children. The preparation is used in children aged 1 year and older.
The ability to influence the reaction rate when driving or operating other mechanisms. The effect of the preparation on the reaction rate when driving vehicles or working with other mechanisms has not been studied. However, patients should be aware that the preparation may cause dizziness or other adverse reactions from the nervous system.
Interactions
The preparation should not be used concomitantly with immunosuppressants. with caution, the preparation is prescribed with xanthine oxidase inhibitors or agents that promote the excretion of uric acid, including diuretics, in particular with thiazide diuretics (such as hydrochlorothiazide, chlorthalidone, indapamide) or loop diuretics (for example, with furosemide, torasemide, ethacrynic acid).
With simultaneous use with zidovudine (azidothymidine), the formation of zidovudine nucleotide is increased by many mechanisms, in particular due to an increase in the bioavailability of azidothymidine in blood plasma and intracellular phosphorylation in human blood monocytes. The result is an increase in the action of zidovudine.
Overdose
Overdose cases have not been identified. serious adverse events other than elevated plasma uric acid levels are unlikely to occur, given toxicity studies in animals. symptomatic treatment.
Storage conditions
In its original packaging at a temperature not exceeding 25 ° c.
Tags: Isoprinosine
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