Lidocain solution for injection 2%, 2ml x 10 ampoules — Made in Hungary — Free Delivery

Product description

Solution for injection Lidocaine is indicated for local anesthesia (terminal, infiltration, conduction) in surgery, ophthalmology, dentistry, otorhinolaryngology; blockade of peripheral nerves and nerve plexuses for various pain syndromes.

Compound

Active substance: lidocaine;

1 ampoule (2 ml) of solution contains anhydrous lidocaine hydrochloride (in the form of lidocaine hydrochloride monohydrate) 40 mg;

Excipients: sodium chloride, water for injection.

Contraindications

• individual hypersensitivity to the components of the preparation, as well as to other amide local anesthetic preparations;
• a history of epileptoform convulsions associated with the administration of lidocaine hydrochloride;
• AV block II and III degree, complete transverse heart block;
• sick sinus syndrome;
• Wolff-Parkinson-White syndrome, Adams-Stokes syndrome;
• severe forms of heart failure (II-III degree);
• severe arterial hypotension;
• severe bradycardia;
• cardiogenic shock;
• complete transverse heart block;
• myasthenia gravis; hypovolemia; porphyria;
• severe renal and / or hepatic impairment;
• retrobulbar administration to patients with glaucoma;
• blood clotting disorders, anticoagulant therapy;
• infection at the injection site;
• non-contact patients.

Mode of application

Before using lidocaine hydrochloride, it is necessary to conduct a skin test for hypersensitivity to the preparation, as evidenced by edema and redness of the injection site.

For local anesthesia, apply by injection (subcutaneously, intramuscularly) and topically on the mucous membranes. Intravascular administration of the preparation should be avoided.

Application features

Pregnant

Contraindicated.

Children

The preparation is not used in children under 12 years of age.

Drivers

After using the preparation, one should not engage in activities that require the speed of psychomotor reactions.

Overdose

The main symptoms are associated with depression of the central nervous system and the cardiovascular system: general weakness, drowsiness, depression, dizziness, disorientation, tonic-clonic seizures, coma, tremors, visual disturbances, ringing in the ears, atrioventricular block, asphyxia, nausea, vomiting, euphoria, psychomotor agitation, asthenia, apnea, bradycardia, decreased blood pressure, collapse. The first symptoms of an overdose in healthy people occur when the concentration of lidocaine hydrochloride in the blood is over 0.006 mg / kg; convulsions - at 0.01 mg / kg.

Treatment: discontinuation of preparation administration, oxygen therapy, vasoconstrictors (norepinephrine, mezaton), anticonvulsants, anticholinergics. The patient should be in a horizontal position; it is necessary to provide access to fresh air, oxygen supply and / or artificial respiration. Treat central nervous system symptoms with benzodiazepines or short-acting barbiturates. If an overdose occurs during anesthesia, a short-acting muscle relaxant should be used. To correct bradycardia and conduction disorders, use atropine (0.5-1 mg intravenously), with arterial hypotension - sympathomimetics in combination with β-adrenergic receptor agonists. In case of cardiac arrest, immediate resuscitation is indicated. It is possible to carry out intubation, artificial ventilation of the lungs. In the acute phase of lidocaine overdose, dialysis is ineffective. There is no specific antidote.

Side effects

on the part of the cardiovascular system: lowering blood pressure, tachycardia - when administered with a vasoconstrictor, bradycardia, peripheral vasodilation, collapse, tachycardia, palpitations, chest pain, heart pain, arrhythmia, slowing heart conduction, transverse heart block, fibrillation ventricular failure, cardiac arrest; very rarely - arterial hypertension;

from the central and peripheral nervous system: excitation of the central nervous system (when used in high doses), anxiety, dizziness, confusion, drowsiness, sleep disturbance, headache, weakness, restlessness, euphoria, nystagmus, loss of consciousness, impaired sensitivity, paresthesia, numbness of the tongue and lips (when used in dentistry); in patients with hypersensitivity - euphoria, tremor, trismus, muscle twitching, motor restlessness, convulsions (the risk of their development increases against the background of hypercapnia and acidosis); persistent anesthesia, paresis or elegy of the lower extremities and loss of sphincter control (for example, cauda equina syndrome) - causes more often other local anesthetics, motor and sensory block, dysarthria, dysphagia, coma;

on the part of the organs of vision: visual impairment, blurred vision, diplopia, nystagmus, flashing "flies" before the eyes, dilated pupils, photophobia, reversible blindness, conjunctivitis;

mental disorders: anorexia, irritability, restlessness, hallucinations, depression, anxiety, sleep disturbances, a state of agitation;

from the respiratory system, chest and mediastinal organs: rhinitis, shortness of breath, shortness of breath, a feeling of suffocation, respiratory depression, bronchospasm, respiratory muscle paralysis, respiratory paralysis (often develops with subarachnoid anesthesia), respiratory arrest;

from the digestive tract: nausea, vomiting, involuntary defecation, abdominal pain;

from the urinary system: involuntary urination;

on the part of the skin and subcutaneous tissue: hyperemia, itching, rash, urticaria;

from the reproductive system: decreased libido and / or potency;

from the immune system: hypersensitivity reactions, including angioedema, generalized exfoliative dermatitis, anaphylactic shock, anaphylactic reactions, suppression of the immune system.

Interaction

Chlorpromazine, pethidine, bupivacaine, quinidine, disopyramide, amitriptyline, imipramine, nortriptyline - when combined with lidocaine, the concentration of the latter in the blood plasma decreases.

Anticonvulsants, barbiturates (phenytoin) - when combined with lidocaine, it is possible to accelerate the metabolism of lidocaine in the liver, decrease the concentration in the blood, and increase the cardiodepressant effect.

Izadrin, glucagon - when combined with lidocaine, the clearance of lidocaine increases.

Norepinephrine, mexiletine - when combined with lidocaine, the clearance of the latter decreases (toxicity increases); hepatic blood flow decreases.

Acetazolamide, thiazide and loop diuretics - when combined with lidocaine, as a result of the creation of hypokalemia, reduce the effect of the latter.

Storage conditions

Store at a temperature not exceeding 25 ° C, out of the reach of children.

The shelf life is 5 years.