Loxidol 15mg 2p x 10 tablets — Made in Turkey — Free Delivery
(Loxidol)
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Description Loxidol 15mg 2p x 10 tablets — Made in Turkey — Free Delivery
Product description
Loxidol tablets are indicated for short-term symptomatic treatment of exacerbation of osteoarthritis. Long-term symptomatic treatment of rheumatoid arthritis and ankylosing spondylitis.
Compound
Active substance: meloxicam;
1 tablet contains meloxicam 15 mg;
Excipients: microcrystalline sodium cellulose; lactose monohydrate, crospovidone; povidone K30; silicon dioxide colloidal magnesium stearate.
Contraindications
- hypersensitivity to meloxicam or other constituents of the preparation, or to active substances with a similar effect, such as NSAIDs, aspirin. Meloxicam should not be given to patients who develop asthma symptoms, nasal polyps, angioedema, or urticaria after taking aspirin or other NSAIDs;
- peptic ulcer in the stage of exacerbation or in history
- gastrointestinal bleeding or perforation, including those associated with a history of previous NSAID therapy, cerebrovascular bleeding, or other hemorrhagic disorders;
- severe liver failure
- severe renal failure, not dialyzed;
- children up to age 16;
- III trimester of pregnancy;
- severe heart failure.
Mode of application
The preparation is intended for oral administration.
The daily dose should be taken 1 time with a glass of water or other liquid during meals.
Adverse reactions can be minimized by using the lowest effective dose for the shortest treatment period necessary to control symptoms. The patient's need for symptomatic relief and his response to treatment should be periodically assessed.
Application features
Pregnant
During the I and II trimester of pregnancy, meloxicam should not be used unless absolutely necessary. If a woman tries to get pregnant or uses meloxicam in the first and second trimesters of pregnancy, the dosage and duration of treatment should be the smallest.
Meloxicam is contraindicated in the third trimester of pregnancy.
Children
Not recommended for children under 16 years of age.
Drivers
Patients with visual impairment, drowsiness or other disorders of the central nervous system are advised to refrain from driving or operating machinery.
Overdose
Symptoms of acute NSAID overdose are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with maintenance therapy. Gastrointestinal bleeding may occur. Severe poisoning can lead to high blood pressure, acute renal failure, liver dysfunction, respiratory depression, coma, seizures, cardiovascular failure, and cardiac arrest. Anaphylactic reactions have been reported with the therapeutic use of NSAIDs, and can also be observed in case of overdose.
In case of an overdose of NSAIDs, symptomatic and supportive measures are recommended. Studies have shown an acceleration of the elimination of meloxicam as a result of taking 4 oral doses of cholestyramine 3 times a day.
Side effects
Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, ground pain, blood vomiting, ulcerative stomatitis, exacerbation of colitis and Crohn's disease.
Interaction
The combination with other NSAIDs is not recommended, including acetylsalicylic acid at a dose of ≥ 500 mg per dose or ≥ 3 g daily dose.
Concomitant use with corticosteroids requires caution due to the increased risk of bleeding or ulceration in the gastrointestinal tract.
The risk of bleeding is significantly increased due to inhibition of platelet function and damage to the gastroduodenal mucosa. NSAIDs can enhance the effects of anticoagulants such as warfarin. The simultaneous use of NSAIDs and anticoagulants or heparin in geriatric practice or at therapeutic doses is not recommended.
In other cases of heparin use, caution is needed because of the increased risk of bleeding. Careful monitoring of the INR (International Normalized Ratio) is required if it is proven impossible to avoid this combination.
Deferasirox. The simultaneous use of meloxicam and deferasirox may increase the risk of gastrointestinal adverse reactions. Caution should be exercised when combining these medicines.
Cholestyramine. Cholestyramine accelerates the elimination of meloxicam due to impaired intrahepatic circulation, therefore, the clearance of meloxicam is increased by 50% and the half-life is reduced to 13 ± 3 hours. This interaction is clinically relevant.
Storage conditions
Store out of the reach of children, at a temperature not exceeding 25 ° C, in the original packaging to protect from light.
Shelf life is 3 years.
Tags: Loxidol
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