Milicsol solution for injection 15 mg/1.5 ml, 5 ampoules — Made in Greece — Free Delivery
(Milicsol )
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Description Milicsol solution for injection 15 mg/1.5 ml, 5 ampoules — Made in Greece — Free Delivery
Product description
Solution for injection "Milicsol" is used for the short-term symptomatic treatment of an acute attack of rheumatoid arthritis and ankylosing spondylitis, when the oral and rectal routes of administration cannot be used.
Composition
The active ingredient is meloxicam (1.5 ml of solution contains 15 mg of meloxicam).
Excipients: meglumine, glycofurol, poloxamer 188, sodium chloride, glycine, sodium hydroxide, water for injection.
Contraindications
- III trimester of pregnancy;
- the patient's age up to 18 years;
- hypersensitivity to meloxicam or other constituents of the drug, or to active substances with a similar effect, such as NSAIDs, aspirin (should not be prescribed to patients who develop asthma symptoms, nasal polyps, angioedema or urticaria after taking aspirin or other NSAIDs);
- gastrointestinal bleeding or perforation associated with previous NSAID therapy in history;
- a history of active or recurrent ulcer / bleeding (two or more separate confirmed cases of ulcer or bleeding);
- severe liver failure;
- severe renal failure, without dialysis;
- gastrointestinal bleeding, history of cerebrovascular bleeding, or other bleeding disorders;
- disorders of hemostasis or the simultaneous use of anticoagulants (contraindications associated with the route of use);
- severe heart failure;
- treatment of perioperative pain in coronary artery bypass grafting.
Mode of application
Intramuscular administration.
One injection of 15 mg once a day. Do not exceed 15 mg / day.
Treatment should be limited to one injection at the beginning of therapy with a maximum duration of up to 2-3 days in justified exceptional cases (for example, when oral and rectal routes of administration are not possible). Adverse reactions can be minimized by using the lowest effective dose for the shortest duration of treatment necessary to control symptoms.
The patient's need for symptomatic relief and his response to treatment should be periodically assessed.
Method of use
The drug should be injected slowly, by deep injection into the upper outer quadrant of the buttock, adhering to a strict aseptic technique. In case of repeated injection, it is recommended to change the injection site, alternating between the left and right buttocks. It is important to check before injection that the needle point is not in the vessel.
The injection should be stopped immediately in case of severe pain during the injection.
In the case of a hip prosthesis, the injection should be given in the other buttock.
Application features
Pregnant
Meloxicam, like other drugs that inhibit the synthesis of cyclooxygenase / prostaglandin, can negatively affect reproductive function and is not recommended for women who want to become pregnant. Therefore, for women who are planning a pregnancy or undergoing examination for infertility, the possibility of discontinuing meloxicam should be considered.
During the I and II trimester of pregnancy, meloxicam should not be used unless absolutely necessary. If a woman who is trying to get pregnant or during the first and second trimester of pregnancy uses meloxicam, the dosage and duration of treatment should be the smallest. Meloxicam is contraindicated during the third trimester of pregnancy.
Although there is no specific data on the drug "Milicsol", it is known about NSAIDs that they can pass into breast milk. Therefore, the use is not recommended for women who are breastfeeding.
Children
Milicsol, solution for injection 15 mg / 1.5 ml, is contraindicated in children (under the age of 18).
Drivers
There are no special studies on the effect of the drug on the ability to drive a car or work with other mechanisms. However, based on the pharmacodynamic profile and adverse reactions that have been observed, meloxicam tends to have little or no effect on said activity. However, patients who have experienced visual impairments, including blurred vision, dizziness, drowsiness, vertigo or other disorders of the central nervous system, are advised to refrain from driving or working with other mechanisms.
Overdose
Symptoms of acute NSAID overdose are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with maintenance therapy. Gastrointestinal bleeding may occur. Severe poisoning can lead to hypertension, acute renal failure, liver dysfunction, respiratory depression, coma, seizures, cardiovascular failure, and cardiac arrest. Anaphylactoid reactions have been reported with the therapeutic use of NSAIDs, which can also be observed in case of overdose. In case of an overdose of NSAIDs, patients are recommended symptomatic and supportive measures. Studies have shown accelerated elimination of meloxicam with 4 oral doses of cholestyramine 3 times a day.
Side effects
Research data and epidemiological data suggest that the use of some NSAIDs (especially in high doses and with long-term treatment) may be associated with a slight increase in the risk of vascular thrombotic events (such as myocardial infarction or stroke). Edema, arterial hypertension and heart failure have been observed with NSAID treatment.
Most of the side effects that have been observed are of gastrointestinal origin. Possible ulcer, perforation, or gastrointestinal bleeding, sometimes fatal, especially in elderly patients. After application, nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melena, blood vomiting, ulcerative stomatitis, exacerbation of colitis and Crohn's disease were observed. Gastritis was observed with a lesser frequency. Severe skin lesions have been reported: Stevens-Johnson syndrome and toxic epidermal necrolysis.
Storage conditions
Store in its original packaging at a temperature not exceeding 25 ° C, out of the reach of children.
The shelf life is 5 years.
Tags: Milicsol
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