Milistan for cough 20 tablets — Made in India — Free Delivery

Combined mucolytic agent containing ambroxol hydrochloride (4 - {[(2-amino-3, 5-diphenyl) methyl] amino} cyclohexanol hydrochloride) and carbocysteine ​​((2r) -2-amino-3 - [(carboxymethyl) sulfanyl] propane acid).

Ambroxol is an active metabolite of bromhexine; in contrast to the original compound, it is more active. Non-toxic, has a wide therapeutic range. It is used for acute and chronic diseases of the respiratory tract, which are accompanied by the formation of viscous, difficult to separate sputum. It normalizes the pathologically altered secretion of glandular cells of the bronchial mucosa, promotes thinning of viscous secretion and facilitates its discharge by increasing mucociliary clearance and changing the ratio of serous and mucous components of sputum, restoring the drainage function of small bronchi and bronchioles. Stimulates Clarke cells and activates hydrolyzing enzymes, which also leads to a decrease in sputum viscosity. Stimulates the formation of endogenous surfactant, without causing excessive secretion, reduces spastic hyperreactivity of the bronchi. Cough and sputum volume are significantly reduced when using the preparation. It is well tolerated even with prolonged use.

Carbocisteine ​​has a mucolytic and expectorant effect due to the activation of sialic transferase, an enzyme of the goblet cells of the bronchial mucosa. Normalizes the quantitative ratio of acidic and neutral sialomucins, which helps to reduce the viscosity of bronchial secretions. Facilitates sputum separation by increasing mucociliary clearance, has antioxidant and pneumoprotective properties, which are due to the ability of sulfhydryl groups to bind free radicals. It also promotes the regeneration of the mucous membrane and the normalization of its morphological structure, activates the function of the ciliated epithelium, restores the secretion of immunoglobulin and the number of sulfhydryl groups of mucus components.

After taking ambroxol, it is almost completely absorbed in the digestive tract, it penetrates well into the lung tissue. Absolute oral bioavailability is 70-80%. The maximum concentration in blood plasma is reached approximately 2 hours after ingestion. The half-life is 9-10 hours. It is excreted mainly in the urine.

The maximum concentration of carbocysteine ​​in the blood plasma and the mucous membrane of the respiratory tract is achieved in 1-3 hours; in the mucous membrane, it persists for 8 hours. It is excreted almost completely in the form of inactive metabolites (inorganic sulfates, diacetylcystine) in the urine. Only a small amount is excreted unchanged in the feces. It can penetrate the placental barrier and accumulate in the amniotic fluid.