Nazol nasal spray 0.05% 10 ml — Made in Germany — Free Delivery

(Nazol )
Nazol nasal spray 0.05% 10 ml — Made in Germany — Free Delivery
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Description Nazol nasal spray 0.05% 10 ml — Made in Germany — Free Delivery

Pharmacological properties

Pharmacodynamics. Oxymetazoline hydrochloride is a synthetic adrenergic agonist. stimulating α-adrenergic receptors of blood vessels, it promotes a pronounced and prolonged vasoconstrictor effect the vasoconstrictor effect is manifested by a decrease in blood flow, a decrease in edema of the mucous membranes of the nose, paranasal sinuses and the Eustachian tube, as a result of which breathing through the nose is restored, which was disturbed by flu, colds and allergic diseases.
Local vasoconstriction of the nasal mucosa and paranasal sinuses occurs 5–10 minutes after injection of the preparation  into the nasal cavity. The decongestant effect lasts up to 12 hours. The preparation has a softening effect on the irritated mucous membrane of the nasal passages and protects it from excessive drying.
Pharmacokinetics. T½ oxymetazoline hydrochloride is 5-8 hours. It is excreted mainly unchanged in the urine and feces.

Indications

Symptomatic treatment of colds, flu, allergic diseases (hay fever), accompanied by acute rhinitis, sinusitis, other sinusitis (frontal sinusitis, ethmoiditis), acute otitis media.

Application

Adults and children from the age of 12 years to do 2 injections, children from 6 to 12 years old - 1 injection in each nasal passage. the bottle should be held upright. repeat the injection no earlier than 12 hours later.
The duration of treatment is no more than 3 days. Longer use is possible - up to 7-10 days, 2 injections per day under the supervision of a physician.

Contraindications

Hypersensitivity to oxymetazoline, other adrenomimetics or other components of the preparation, severe forms of ages, severe atherosclerosis, acute cardiovascular diseases or cardiac asthma, tachysystolic heart rhythm disturbances, angina pectoris, renal failure, severe prostatic hypertrophy, pheochromocytoma, metabolic disorders , diabetes mellitus), atrophic rhinitis, increased intraocular pressure, especially in angle-closure glaucoma, after transsphenoidal hypophysectomy or other surgical intervention with the opening of the dura mater, patients with inflammation or damage to the skin around the nasal passages or nasal mucosa, the use of preparations that increase blood pressure ; simultaneous use with MAO inhibitors and use within 2 weeks after stopping treatment with MAO inhibitors.

Side effects

With frequent and prolonged use, there may be sensations of burning, tingling in the nose, flushing of the face, sneezing, dryness of the nasal mucosa. rarely - after the effect of the preparation is over, - a feeling of severe nasal congestion (reactive hyperemia). long-term continuous use of vasoconstrictor preparations can lead to tachyphylaxis or the development of rhinitis medicamentosa. in general, severe side effects are not expected.
On the part of the cardiovascular system. Tachycardia, palpitations, increased blood pressure, heart pain are very rare.
On the part of the organ of vision. Rarely, there may be eye irritation, discomfort or redness, and blurred vision.
From the gastrointestinal tract. Rarely, nausea may occur.
From the immune system. In rare cases, hypersensitivity reactions are possible, including rash, itching, Quincke's edema.
Disturbances from the respiratory system, chest and mediastinal organs. Rarely, there may be discomfort or irritation in the nose, mouth, throat, and nosebleeds.
From the nervous system. Anxiety, nervousness, anxiety, insomnia, drowsiness, tremors, hallucinations (especially in children), increased fatigue, headache, dizziness.
Skin and subcutaneous tissue disorders. Rash.
Skeletal muscle and connective tissue disorders. Convulsions (especially in children).
General violations. Weakness.

Special instructions

When injecting into the nasal cavity, do not throw your head back and do not turn the bottle over. it is not recommended to use one bottle for several people to avoid spreading the infection.
The persistence of swelling of the nasal passages after the third day of use may indicate the presence of curvature of the nasal septum, purulent sinusitis, adenoids, allergic rhinitis, persistent bacterial infection or other undiagnosed diseases requiring the consultation of a specialized specialist and specialized complex therapy.
You should consult your doctor before using this preparation in the following cases: high blood pressure, cardiovascular disease, liver or kidney disorders, porphyria.
Long-term use and preparation overdose should be avoided. Prolonged use of a decongestant can weaken its effect. Abuse of this preparation can cause mucosal atrophy and reactive hyperemia with rhinitis medicamentosa, as well as damage to the mucous epithelium and inhibition of epithelial activity. Doses higher than recommended should be used only under medical supervision. Do not exceed the recommended dosage.
Use during pregnancy and lactation. The use of oxymetazoline was not associated with an adverse termination of pregnancy. It should be used with caution in patients with hypertension or signs of decreased blood supply to the placenta. Frequent or prolonged use of high doses can lead to a decrease in placental blood flow. The use of the preparation in women during pregnancy is possible only if, in the opinion of the doctor, the benefits to the mother outweigh the potential risk to the fetus / child.
It is not known whether oxymetazoline passes into breast milk. Due to the lack of data, oxymetazoline should not be used during breastfeeding.
Children. Should not be used in children under 6 years of age.
The ability to influence the reaction rate when driving or working with other mechanisms. After prolonged use of the preparation in doses exceeding the recommended ones, a general effect on the cardiovascular system cannot be ruled out. In such cases, the ability to drive a vehicle may deteriorate.

Interactions

When using other preparations, it is recommended to consult a doctor before starting treatment with this preparation. use the preparation in combination with other vasoconstrictor agents (for any route of administration of the latter) or with other nasal decongestants, as well as tricyclic antidepressants, after consulting a doctor, since blood pressure may increase.
With the simultaneous use of MAO inhibitors and oxymetazoline, an increase in blood pressure is possible. Therefore, you should not take this preparation at the same time or within 2 weeks after stopping treatment with MAO inhibitors.
With the simultaneous use of oxymetazoline with tricyclic antidepressants, an increase in the risk of increased blood pressure and arrhythmia is possible.
Oxymetazoline may reduce the effectiveness of β-blockers, methyldopa, or other antihypertensive preparations.
With the simultaneous use of sympathomimetics and antiparkinsonian preparations, an additive toxic effect on the cardiovascular system is possible.

Overdose

When applied topically, there are usually no side systemic reactions.
Symptoms of an oxymetazoline overdose are different. The stages of hyperreactivity and inhibition are distinguished. Stimulation of the central nervous system is clinically manifested in the form of a feeling of fear, excitement, hallucinations, and seizures.
Overdose symptoms of moderate to severe severity are miosis (pupillary constriction), mydriasis (pupil dilation), nausea, vomiting, cyanosis, fever, increased sweating, spasms, tachycardia, arrhythmia, cardiac arrest, increased blood pressure, pulmonary edema, shortness of breath, physical discomfort ...
Depression of the central nervous system is clinically manifested in the form of drowsiness, decreased body temperature, bradycardia, arterial hypotension, collapse, respiratory disorders and respiratory arrest, coma.
The clinical manifestations of an overdose in children include symptoms from the central nervous system: convulsions and coma, hallucinations, bradycardia, apnea, hypertension, which is replaced by hypotension.
Urgent Care. If an overdose of oxymetazoline is suspected, urgent hospitalization is required in the intensive care unit. Activated charcoal and laxatives are prescribed. Gastric lavage is necessary. In order to reduce elevated blood pressure, α-adrenergic receptor blockers (phentolamine) should be prescribed. It is not recommended to take vasopressors. Anticonvulsant therapy is indicated if necessary. In severe cases, intubation and mechanical ventilation may be necessary.

Storage conditions

At a temperature not exceeding 30 ° c.

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