Neovitam 30 tablets — Made in Ukraine — Free Delivery

(Neovitam)
Neovitam 30 tablets — Made in Ukraine — Free Delivery
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Kyiv Vitamin Plant Brand: Kyiv Vitamin Plant

Pharmacological properties

Pharmacodynamics. The preparation contains a combination of neurotropic active substances of the complex of vitamins b: thiamine (b1), pyridoxine (b6) and cyanocobalamin (b12) are of particular importance as coenzymes in intermediate metabolism occurring in the central and peripheral nervous system. like all other vitamins, they are essential nutrients that cannot be synthesized directly in the body.

Therapeutic introduction of vitamins B1, B6 and B12 into the body replenishes the insufficient intake of vitamins with food, which ensures the presence of the required amount of coenzymes in the body. The therapeutic use of these vitamins for various diseases of the nervous system is aimed at, on the one hand, compensating for the simultaneously existing deficiency (possibly due to an increase in the body's demand caused by the disease itself) and, on the other hand, stimulating natural recovery mechanisms.

Vitamins B1, B6 and B12 have very low toxicity and do not pose a potential risk to humans.

Pharmacokinetics.

Thiamin. After oral administration, it is subjected to dosed transport, the mechanism of which has a dual nature: active absorption up to a concentration of 2 μmol and passive diffusion at concentrations of more than 2 μmol. T½ is about 4 hours. The human body can accumulate up to 30 mg of thiamine. Due to the rapid metabolism, reserve reserves of the vitamin are very limited and are depleted after 4-10 days.

Pyridoxine. Pyridoxine is absorbed very quickly, mainly in the upper gastrointestinal tract, and is excreted after a maximum of 2-5 hours.

The human body can store approximately 40–150 mg of the vitamin, 1.7–3.6 mg is excreted in the urine per day.

Cyanocobalamin. Vitamin B12 is absorbed in the digestive tract through two mechanisms:

release under the action of gastric juice and rapid combination with intrinsic factor;

regardless of the intrinsic factor due to passive entry into the blood.

At doses above 1.5 μg, the latter mechanism plays a significant role.

Vitamin B12 is accumulated mainly in the liver. The metabolic rate is 2.5 μg / day, or 0.05% of the amount that is retained. Vitamin B12 is mainly excreted in the bile and is largely reabsorbed during the intestinal-hepatic circulation.

Indications

As part of the complex therapy of neurological diseases:

  • trigeminal neuralgia;
  • intercostal neuralgia;
  • sciatica;
  • lumbar syndrome (lumbago);
  • plexitis (cervical and brachial plexus);
  • radicular neuritis due to degenerative diseases of the spine;
  • prosoplegia (damage to the facial nerve).

Application

The tablets should be taken after meals, without chewing, with a small amount of liquid.

The recommended dose is 1 tablet per day. In individual cases, the dose is increased and 1 tablet is used 3 times a day.

The duration of the course of treatment is determined by the doctor individually in each case. After a period of treatment lasting 4 weeks, the doctor decides on the correction and reduction of doses of the preparation.

Contraindications

Hypersensitivity to any component of the preparation.

Vitamin B1 is contraindicated for allergic diseases.

Vitamin B6 is contraindicated for use in case of stomach and duodenal ulcers in the acute stage (since the acidity of gastric juice may increase).

Vitamin B12 is contraindicated for erythremia, erythrocytosis, thromboembolism.

Side effects

From the nervous system: long-term use (more than 6-12 months) in doses of more than 50 mg of vitamin B6 daily can lead to peripheral sensory neuropathy, nervous excitement, malaise, dizziness, headache.

From the gastrointestinal tract: gastrointestinal disorders, including nausea, vomiting, diarrhea, abdominal pain, increased acidity of gastric juice.

From the immune system: anaphylactic shock, anaphylaxis, skin reactions, including itching, urticaria.

General disorders: chronic abuse of extremely high doses of vitamin B6 can cause sensory disturbances, increased sweating, and tachycardia.

Special instructions

The preparation in large doses should not be used for more than 4 weeks, since this can provoke neurological symptoms. drinking alcohol and black tea reduces the absorption of thiamine. Drinking beverages containing sulfites (such as wine) increases the degradation of thiamine.

Since the preparation contains vitamin B6, it should be used with caution in patients with a history of peptic ulcers and duodenal ulcers, severe renal and liver dysfunctions.

With the introduction of vitamin B12, the clinical picture, as well as laboratory tests for funicular myelosis or pernicious anemia, may lose their specificity.

Patients with neoplasms, with the exception of cases accompanied by megaloblastic anemia and vitamin B12 deficiency, should not use the preparation.

The preparation is not used for severe or acute decompensation of cardiac activity and angina pectoris.

Use during pregnancy and lactation. The use of the preparation during pregnancy and lactation is not recommended.

Children. The use of the preparation in children is contraindicated due to the lack of clinical experience.

The ability to influence the reaction rate when driving or working with other mechanisms. The medicinal product does not affect the ability to drive a car or work with other mechanisms. In cases where dizziness is observed during drug treatment, you should refrain from driving and working with mechanisms.

Interactions

The action of thiamine is inactivated by 5-fluorouracil, since the latter competitively inhibits the phosphorylation of thiamine into thiamine pyrophosphate.

Antacids reduce the absorption of thiamine. Loop diuritics that inhibit tubular reabsorption (eg furosemide) during long-term therapy can cause an increase in thiamine excretion and thus reduce thiamine levels.

Concomitant use with pyridoxine antagonists (for example, isoniazid, hydralazine, penicillamine or cycloserine), oral contraceptives may increase the need for vitamin B6.

With the simultaneous use of vitamin B6 can reduce the effectiveness of levodopa.

Overdose

Vitamin B1: has a wide therapeutic range. very high doses (more than 10 g) show a curariform effect, inhibiting the conduction of nerve impulses.

Vitamin B6: very low toxicity. Neuropathies with ataxia and sensory impairment, cerebral convulsions with ECG changes, as well as, in some cases, hypochromic anemia and seborrheic dermatitis have been described after application of more than 2 g / day.

Excessive use of vitamin B6 in doses of more than 1 g / day for several months can lead to neurotoxic effects.

Vitamin B12. After parenteral administration (very rarely after oral administration), high doses have been noted for allergic reactions, eczematous skin disorders and benign acne.

With prolonged use of vitamin B12 in high doses, a violation of the activity of liver enzymes, pain in the region of the heart, hypercoagulation is possible.

Storage conditions

In its original packaging at a temperature not exceeding 25 ° C.

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