Nicotinic acid-Darnitsa solution for injection 10 mg/ml, 2p x 10 ampoules — Made in Ukraine — Free Delivery
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Description Nicotinic acid-Darnitsa solution for injection 10 mg/ml, 2p x 10 ampoules — Made in Ukraine — Free Delivery
Pharmacological properties
Pharmacodynamics. Nicotinic acid (vitamin pp) alone or in the form of an amide is a prosthetic group of enzymes - codehydrase i (diphosphopyridine nucleotide - over) and codehydrase ii (triphosphopyridine nucleotide - overp), which carry out the transfer of hydrogen in redox reactions, as well as the transfer of phosphate.
Taking part in metabolism, tissue respiration, synthesis processes, nicotinic acid normalizes the content of lipoproteins and triglycerides in the blood.
It has a vasodilating effect at the level of prearterioles and arterioles (including the brain), as a result of which microcirculation improves.
It has a weak anticoagulant effect (increases the fibrinolytic activity of the blood), has detoxification properties due to the enhancement of the detoxification function of the liver and kidneys.
Eliminates vitamin PP deficiency, is a specific antipellagric agent.
Pharmacokinetics. Nicotinic acid is rapidly absorbed from the injection site when administered parenterally. It is evenly distributed over all organs and tissues. It is inactivated mainly by methylation and to a lesser extent by conjugation. Biotransformation products are excreted in the urine. Nicotinic acid can be detected in urine in an active form if an increased amount of it enters the body.
Indications
Pellagra treatment (vitamin pp vitamin deficiency). ischemic disorders of cerebral circulation. vasospasm of the extremities (obliterating endarteritis, Raynaud's disease). vasospasm of the kidneys. wounds, ulcers that do not heal for a long time. complications of diabetes mellitus (diabetic polyneuropathy, microangiopathy). hypoacid gastritis, enterocolitis, colitis. liver diseases (acute and chronic hepatitis). neuritis of the facial nerve. intoxication of various origins: professional, alcoholic, medication (aniline derivatives, barbiturates, anti-tuberculosis preparations, sulfonamides).
Application
Prescribe to adults and children over the age of 15 years intravenously (slowly), intramuscularly and subcutaneously (intramuscular and subcutaneous injections are painful).
For intravenous jet injection, a single dose of the preparation is diluted in 10 ml of 0.9% sodium chloride solution and administered in at least 5 minutes (no more than 2 mg of nicotinic acid in 1 minute).
For intravenous drip administration, a single dose of the preparation is diluted in 100-200 ml of 0.9% sodium chloride solution, the rate of administration is 30-40 drops per minute.
Pellagra. Prescribe 10 mg (1 ml) 1–2 times a day intravenously or intramuscularly. The course of treatment is 10-15 days.
Ischemic disorders of cerebral circulation. IV (slowly) inject 10 mg (1 ml).
Other indications. Prescribe s / c or i / m at 10 mg (1 ml) 1 time per day for 10-15 days. It is possible to add 10 mg (1 ml) of nicotinic acid to the infusion solution per 100-200 ml of solution.
Higher doses for intravenous administration: single - 100 mg (10 ml), daily - 300 mg (30 ml).
Contraindications
Hypersensitivity to the components of the preparation. peptic ulcer and duodenal ulcer (in the acute stage), gout, hyperuricemia, severe hepatic failure (including cirrhosis), severe forms of ag and atherosclerosis (IV injection), decompensated diabetes mellitus, recent myocardial infarction, sudden decrease in peripheral vascular history of resistance.
Side effects
From the side of the cardiovascular system: hot flashes, which may be accompanied by shortness of breath, tachycardia, palpitations, increased sweating, chills, swelling, tingling and burning sensations; arrhythmia; with rapid intravenous administration - a significant decrease in blood pressure, orthostatic hypotension, collapse.
From the side of the central and peripheral nervous system: dizziness, paresthesia, headache.
From the immune system, skin and subcutaneous tissue: hyperemia of the skin of the face and upper half of the body with a tingling sensation and burning, dry skin and mucous membranes of the eyes, rarely - edema of the retina, very rarely in patients with coronary artery disease - acanthosis. These symptoms are unstable and disappear after discontinuation of the preparation. Hypersensitivity reactions, including from the respiratory system, urticaria, itching, rash.
Local reactions: soreness, swelling at the site of s / c and i / m injections.
With long-term use in high doses - hyperuricemia, decreased glucose tolerance, liver dysfunction, fatty liver disease, jaundice, increased levels of AST, LDH, alkaline phosphatase, uric acid, hypophosphatemia, decreased platelet count, increased prothrombin time, hyperpigmentation, hyperkeratosis, convulsions , diarrhea, nausea, vomiting, anorexia, exacerbation of stomach ulcers, amblyopia, insomnia, myalgia, decreased blood pressure, rhinitis, blurred vision, eyelid edema, myopathy, exfoliative dermatitis.
special instructions
Since prolonged use can lead to fatty degeneration of the liver, for the prevention of the latter, methionine-rich foods should be included in the diet of patients or methionine, lipoic acid should be prescribed. in the course of treatment, it is necessary to monitor liver function. in case of hypersensitivity to the preparation (except for cases of use as a vasodilator), it can be replaced with nicotinamide.
Use with caution in hyperacid gastritis, gastric ulcer and duodenal ulcer (outside the stage of exacerbation), hemorrhages, glaucoma, renal failure, moderate arterial hypotension, alcohol abuse, unstable angina pectoris (patients taking nitrates, calcium channel antagonists, β-adrenoreceptor blockers ).
The use of the preparation can lead to an increase in the need for insulin in patients with diabetes mellitus. It is inappropriate to use for the correction of dyslipidemia in patients with diabetes mellitus.
It is necessary to regularly monitor glucose levels in connection with a possible decrease in glucose tolerance, as well as the level of uric acid in blood plasma due to a possible increase as a result of prolonged therapy.
Use during pregnancy and lactation. The preparation is contraindicated during pregnancy. If necessary, use of the preparation should stop breastfeeding.
Children. The preparation should be prescribed to children over the age of 15 years.
The ability to influence the reaction rate when driving vehicles or other mechanisms. Studies on the effect of the preparation on the reaction rate have not been conducted, however, if dizziness and drowsiness are observed during treatment, one should refrain from working with mechanisms.
Interactions
Oral contraceptives and isoniazid reduce the conversion of tryptophan to nicotinic acid and thus may increase the need for nicotinic acid.
Nicotinic acid reduces the effectiveness and toxicity of probenecid, neomycin, barbiturates, anti-tuberculosis preparations, sulfonamides.
Antibiotics can increase the redness of the skin caused by niacin.
Acetylsalicylic acid reduces the reddening effect of the skin caused by niacin.
Ciprofibrate is not recommended to be combined with nicotinic acid.
Lovastatin, pravastatin, due to the increased risk of adverse reactions, is not recommended to be combined with nicotinic acid. There are reports of cases of rhabdomyolysis when using nicotinic acid with lovastatin.
Care must be taken when combined with antihypertensive preparations (possibly increased hypotensive action), anticoagulants, acetylsalicylic acid (due to the risk of hemorrhage).
The preparation potentiates the action of fibrinolytic agents, antispasmodics and cardiac glycosides, the toxic effect of alcohol on the liver.
Incompatibility. Do not mix with solutions of thiamine chloride (thiamine is destroyed), pyridoxine hydrochloride, cyanocobalamin, aminophylline, salicylates, tetracycline, sympathomimetics, hydrocortisone.
Overdose
Symptoms: increased side effects from the cardiovascular system - arterial hypotension, headache, possible loss of consciousness, dizziness, a feeling of flushing.
Treatment: preparation withdrawal, detoxification therapy, symptomatic treatment. There is no specific antidote.
Storage conditions
In its original packaging at a temperature not exceeding 25 ° C. do not freeze.
Tags: Nicotinic
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