Nifuroxazide Alkaloid 100 mg, 2p x 30 capsules — Made in Macedonia — Free Delivery

Pharmacodynamics. Nifuroxazide is a 5-nitrofuran derivative that acts exclusively in the intestinal lumen and is not absorbed from the gastrointestinal tract. local activity and the lack of penetration into the organs and tissues of the body determines the uniqueness of nifuroxazide in comparison with other nitrofuran derivatives, since there are no systemic effects. the mechanism of action of nifuroxazide is not fully understood. the antimicrobial and antiparasitic properties of nifuroxazide and other nitrofurantoin derivatives are due to the no2-group, which is most effective in the treatment of intestinal infections. the preparation is especially effective against gram-positive bacteria: streptococcus pyogenes, staphylococcus pyogenes and gram-negative bacteria: escherichia coli, salmonella and shigella.

Suction. After oral administration, the absorption of nifuroxazide in the gastrointestinal tract is extremely low, since more than 99% of the taken preparation remains in the intestine.

Distribution. Nifuroxazide is practically not absorbed from the digestive tract, and ultimately absorption does not exceed 0.005%, since there is no distribution to organs and tissues.

Metabolism. Biotransformation of nifuroxazide occurs in the intestine, only 20% of the administered amount of the preparation is excreted unchanged.

Excretion. Nifuroxazide and its metabolites are excreted completely in the feces. The rate of elimination depends on the amount of the preparation taken and the motility of the gastrointestinal tract.

Usually, elimination of nifuroxazide is slow, and the preparation remains in the digestive tract for a long time.

Acute diarrhea of ​​infectious etiology.

For oral administration.

Nifuroxazide Alkaloid capsules. Adults and children over the age of 12.

Adults: a single dose of 200 mg (or 2 capsules of 100 mg) 4 times a day.

Children (from 12 years old): 200 mg (or 2 capsules of 100 mg) 3-4 times a day (600-800 mg of nifuroxazide per day). The duration of treatment is no more than 7 days. If necessary, the use of the preparation can be extended depending on the clinical condition of the patient.

Nifuroxazide Alkaloid, suspension. The dose is set by means of a measuring cup. Shake the prepared suspension well before use!

Adults: 200 mg - 5 ml of suspension 4 times a day.

Children over 12 years of age: 5 ml 3-4 times a day (600-800 mg of nifuroxazide per day); children aged 2–12 years: 5 ml 3 times a day (600–800 mg of nifuroxazide per day). The duration of treatment is no more than 7 days.

Children. Children under the age of 12 are advised to use the preparation Nifuroxazide Alkaloid in the form of an oral suspension. Do not administer Nifuroxazide Alkaloid in the form of an oral suspension to children under 2 years of age.

Hypersensitivity to nitrofuran derivatives and / or preparation excipients.

In patients with hypersensitivity to nitrofuran derivatives, granulocytopenia may occur; allergic reactions, usually of a skin type (skin rash, itching, urticaria, pustulosis). in isolated cases, as with the use of other nitrofuran derivatives, shortness of breath, severe hypersensitivity reactions, including angioedema and anaphylactic shock, may occur.

In case of severe adverse reactions, the preparation should be canceled and symptomatic therapy should be carried out. Further, the patient should avoid taking nifuroxazide and other nitrofuran derivatives.