Peritol 4mg 20 tablets — Made in Hungary — Free Delivery

Pharmacological properties

Antihistamine (h1-receptor blocker) with antiserotonin activity. prevents the development and facilitates the course of allergic reactions. in addition to antiallergic, it has antipruritic, antiexudative, anticholinergic and sedative effects, stimulates appetite.

When taken orally, it is rapidly and well absorbed in the gastrointestinal tract. The maximum concentration in the blood is reached during the first 2 hours; the therapeutic level of concentration is maintained for 4-6 hours. The penetration of the preparation through the placental barrier and into breast milk has not been proven. It is extensively metabolized in the liver, from 2 to 20% is excreted through the stomach, 34% - unchanged. At least 40% of the administered dose of the preparation is excreted in the urine. The half-life is 16 hours.

Indications

Acute and chronic urticaria, serum sickness, hay fever, vasomotor and allergic rhinitis; allergic reactions that occur when taking medications, exanthema, eczematous, contact dermatitis, neurodermatitis, angioedema, insect bites, carcinoid syndrome, headache of vascular origin (migraine, "histamine" headache). the preparation can also be used for anorexia of various origins (anorexia nervosa, idiopathic anorexia), as well as for cachexia (due to an infectious disease, exhaustion, hyperthyroidism).

Application

Tablets: usually the initial daily dose is 12 mg (1 tablet 3 times a day). this dose can be increased to a maximum of 32 mg / day (until the symptoms of the disease disappear or as directed by a doctor).

Chronic urticaria: 6 mg / day (1/2 tablet 3 times a day) until the symptoms of the disease disappear.

Acute migraine attack: 1 tablet. If the pain continues to bother, taking the preparation in the same dose can be repeated after 30 minutes, but not more than 8 mg (2 tablets) for 4-6 hours.

For maintenance therapy, in most cases, it is sufficient to take 4 mg (1 tablet) 3 times a day.

Anorexia: in case of anorexia, take 1 tablet 3 times a day. For children aged 3–6 years - 6 mg / day (1/2 tablet 3 times a day). The maximum dose can be increased to 8 mg / day (no more than 2 tablets).

For children aged 7-14 years, the dose is 12 mg / day (1 tablet 3 times a day).

Syrup: adults: usually the initial dose is 12 mg (10 ml of syrup 3 times a day).

This dose can be increased to a maximum of 32 mg / day (4 times 20 ml of syrup).

With chronic urticaria for adults - 6 mg / day (5 ml of syrup 3 times a day), with migraine — 4 mg / day (10 ml of syrup at the same time). If the pain continues to bother, taking the preparation in the same dose can be repeated after 30 minutes. Do not use a dose higher than 8 mg (10 ml 2 times a day) for 4-6 hours.

For maintenance therapy, it is usually sufficient to take 12 ml (3 times 10 ml / day). The period of treatment depends on the effectiveness of therapy and the patient's condition and is determined by the doctor.

Children aged 2–6 years are prescribed a dose of 0.25 mg / kg of body weight; at the age of 7-14 years, the daily dose is 8-12 mg (10 ml of syrup 2-3 times a day).

1 teaspoon contains 5 ml of syrup. 1 dessert spoon contains 10 ml of syrup.

In patients with impaired renal and hepatic function, it may be necessary to reduce the dose.

Contraindications

Peritolne tablets and syrup are used for:

• hypersensitivity to preparation components;

• glaucoma;

• peripheral edema;

• benign prostatic hyperplasia;

• violation of urination;

• during pregnancy and lactation;

• children under 2 years of age.

Side effects

CNS: most often - drowsiness, as a rule, passing after 3-4 days, sometimes, as a result, you have to stop taking the preparation. other side effects include sedation, dizziness, tinnitus, confusion, impaired coordination of movements, ataxia, impaired accommodation (mydriasis), double vision, visual hallucinations, anxiety, tremor, irritability, insomnia, paresthesia, neuritis, headache pain, weakness.

Allergic reactions: erythema, purpura, urticaria, edema. In some cases - Quincke's edema and anaphylactic shock.

Skin: erythema, skin rash, photosensitivity.

Hematopoietic system: hemolytic anemia, leukopenia, agranulocytosis, thrombocytopenia.

Cardiovascular system: hypotension, tachycardia, extrasystole.

Respiratory systems: thickening of bronchial secretions, dyspnea, runny nose.

Gastrointestinal tract: dry mouth, nausea, vomiting, epigastric discomfort, diarrhea or constipation, cholestasis, hepatitis, jaundice.

Urinary system: frequent urge to urinate, difficulty emptying the bladder, urinary retention.

Other side effects: during the period of taking the preparation Peritol, the body weight of patients often increases.

Special instructions

Due to the sedative effect of the preparation at the beginning of the course of treatment, it is recommended to use the first dose in the evening after the last meal.

When using Peritol in weakened patients or elderly patients, caution should be exercised, since they are more likely to develop side effects (dizziness, drowsiness, hypotension).

Care should be taken when treating children as they are more likely to develop side effects such as anxiety.

In the initial period of therapy, patients may complain of dizziness, drowsiness. Therefore, at the beginning of the course of treatment with Peritol, it is necessary to refrain from driving vehicles and working with mechanisms, as well as performing work requiring increased attention. In the future, the degree of this limitation is determined individually.

Due to the presence of an anticholinergic effect, it is recommended to be careful when prescribing the preparation Peritol in the following conditions:

• BA;

• high intraocular pressure;

• hyperthyroidism;

• cardiovascular diseases;

• AG.

Alcohol can increase the inhibitory effect of antihistamines on central nervous system function (sedation). Therefore, during the period of treatment with Peritol, it is prohibited to consume alcoholic beverages.

Long-term use of antihistamines can in some cases cause a violation of hematopoiesis (leukopenia, agranulocytosis, thrombocytopepia, hemolytic anemia). Therefore, patients with complaints of unexplained fever, sore throat, lesions of the oral mucosa, jaundice, ecchymosis, persistent bleeding should be carefully examined with a hemogram. If serious violations are identified, the need to discontinue the preparation should be considered.

Peritol syrup contains sucrose. 1 teaspoon (5 ml) contains 2 g, 1 dessert spoon (10 mg) contains 4 g of sucrose. Therefore, the appointment of the syrup is contraindicated in children with fructose intolerance or impaired absorption of glucose / galactose, as well as sucrose / maltose deficiency.

Peritol contains 5% alcohol. 1 teaspoon of syrup (5 ml) contains 0.25 g, and 1 dessert spoon (10 mg) contains 0.5 g of alcohol. The use of Peritol syrup should be prescribed with great caution in liver diseases, alcoholism, epilepsy, brain injury or other diseases of the central nervous system. Long-term (more than 1 week) use of syrup in children should be carried out only after careful weighing of the benefit / risk ratio.

The syrup should be used within 4 weeks after opening the bottle.

Interactions

MAO inhibitors enhance and increase the duration of the anticholinergic effect of the preparation.

Caution is necessary with the simultaneous use of the preparation Peritol and other substances that inhibit the activity of the central nervous system (hypnotics, sedatives, anxiolytics, alcohol), while their sedative effect may be enhanced

Overdose

Symptoms: in children - excessive agitation, anxiety, hallucinations, convulsions. in adults - depression, coma, sometimes psychomotor agitation, convulsions.

Treatment: gastric lavage, the use of activated carbon; with the development of pronounced atropine-like effects - parenteral administration of a solution of physostigmine salicylate; according to indications - vasoconstrictor and anticonvulsant preparations. Artificial ventilation of the lungs and other resuscitation measures.

Storage conditions

At a temperature of 15-25 ° C. after opening the syrup bottle, use it for 4 weeks.