Pimafucin 100mg 3 suppositories — Made in Italy— Free Delivery

Pharmacological properties

Pharmacodynamics. Natamycin is a broad-spectrum polyene antibiotic that is active against pathogenic fungi, including yeasts and especially candida albicans, which are most often the cause of genital tract infections. acts fungicidal, binding sterols of cell membranes, violates their integrity, causing the death of microorganisms.

The preparation does not show sensitizing activity. There were no cases of allergy to natamycin during treatment or during its industrial production, and there was no development of resistance to it.

Due to its enteric coating, the tablet acts only in the intestine.

The preparation acts quickly and effectively when the vagina is infected with yeast (candidiasis). Vaginal suppositories also have a therapeutic effect in the presence of vaginal discharge, inflammation and itching, including the upper, less accessible parts of the vagina. The preparation quickly melts in the vagina, forming a foamy mass, which contributes to the even and complete distribution of the active substance over its entire surface.

Pharmacokinetics. When taken orally in the form of tablets, natamycin is practically not absorbed in the gastrointestinal tract.

The existing methods failed to detect natamycin, which was used intravaginally, and its derivatives in the blood and biological fluids of the body, which indicates the absence of a systemic effect of the preparation.

Natamycin is active when applied topically and is not absorbed through the skin and mucosal membranes.

Indications

Tablets: fungal intestinal diseases; vaginal suppositories: vaginitis caused by candida albicans; cream: fungal skin lesions caused by candida albicans.

Application

Pills. for the treatment of intestinal candidiasis, adults are prescribed 1 tablet 4 times a day. usually therapy lasts 1 week.

Children aged 3 years and older are prescribed 1 tablet 2 times a day. Due to the peculiarities of the pharmacodynamic and pharmacokinetic properties of natamycin, the same dose is recommended for children of all ages. Usually the duration of treatment is 1 week.

Suppositories. Used in adult women, 1 suppository for 3-6 days. Suppositories are recommended to be inserted as deeply as possible into the vagina (in the supine position) 1 time per day (at night). If it is necessary to carry out treatment for several days, the course of therapy should be completed before the onset of menstruation or treatment should be started after it ends.

The cream is applied to the affected skin 1–4 times a day every day. The duration of therapy is usually 2-3 weeks.

Contraindications

Hypersensitivity to the components of the preparation.

Side effects

Pills

From the gastrointestinal tract: nausea and diarrhea are possible (which occur in the first days of use and disappear on their own during treatment).

Hypersensitivity reactions are possible.

Suppositories. Rarely (0.01%, 0.1%)

Skin and subcutaneous tissue: hypersensitivity reaction, burning sensation and irritation.

Cream

Hypersensitivity Reactions: Some irritation or burning sensation may occur at the application site. If they persist, it may be due to hypersensitivity to preservatives (parahydroxybenzoates). The presence of methyl parahydroxybenzoate and propyl parahydroxybenzoate in the preparation can cause allergic reactions (possibly delayed).

Special instructions

The use of natamycin in the form of tablets may be associated with the development of an acute attack of porphyria, therefore, the use of the preparation is considered unsafe for patients with this disease.

Since the preparation in the form of tablets contains lactose, it should not be used in patients with rare hereditary forms of galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

The preparation contains sucrose, which should be taken into account in patients with diabetes mellitus. Since the preparation contains sucrose, it should not be used in patients with rare hereditary diseases, such as fructose intolerance or sucrase-isomaltase deficiency.

During menstruation, treatment with Pimafucin® in the form of vaginal suppositories should be interrupted. During preparation therapy, there is no need to avoid sexual intercourse.

During pregnancy and breastfeeding. Pimafucin® can be prescribed during pregnancy and lactation.

Children. Natamycin in the form of coated tablets is used in children over the age of 3 years; in the form of a cream - in children of all age groups; in the form of vaginal suppositories - not used in children.

The ability to influence the reaction rate when driving and working with other mechanisms. Does not affect.

Interactions

Not described.

Overdose

No messages. when using vaginal suppositories, a systemic effect is practically excluded, since the preparation is not absorbed through the mucous membrane.

Storage conditions

At a temperature not exceeding 25 ° c.