Proginorm Gesta 100mg 30 capsules — Made in Spain — Free Delivery
(Proginorm Gesta)
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Description Proginorm Gesta 100mg 30 capsules — Made in Spain — Free Delivery
Product description
Progynorm Gesta capsules are used for the following indications:
- reduced fertility in primary or secondary infertility with partial or complete luteal insufficiency (dysovulation, support of the luteal phase during preparation for in vitro fertilization, egg donation program);
- prevention of habitual miscarriage or the threat of spontaneous miscarriage in luteal insufficiency;
- prevention of preterm birth in women with a short cervix or in women with a history of spontaneous preterm birth.
Compound
The active substance is progesterone (one soft capsule contains progesterone 100 mg).
Excipients: peanut oil, soy lecithin; capsule shell: gelatin 150 Bloom, glycerin 99%, titanium dioxide (E171).
Contraindications
- hypersensitivity to the components of the drug;
- severe violations of the liver;
- suspected or confirmed neoplasia of the breast or genital organs;
- undiagnosed vaginal bleeding;
- unsuccessful or incomplete abortion;
- thrombophlebitis, thromboembolic disorders;
- hemorrhage in the brain;
- porphyria.
Mode of application
The duration of treatment depends on the nature of the disease.
Capsules are injected deep into the vagina in the supine position.
Before each use of the preparation, wash your hands thoroughly so that there is no detergent left on your hands.
The average dose is 200 mg of progesterone per day (two capsules of 100 mg, in 2 doses, in the morning and evening, which are injected deep into the vagina, if necessary with the help of an applicator). The dose may be increased depending on the response of the patient.
With partial insufficiency of the luteal phase (dysovulation, menstrual irregularities), the daily dose is 200 mg for 10 days (usually from the 17th to the 26th day of the cycle).
With complete insufficiency of the luteal phase (complete absence of progesterone in women with non-functioning (absent) ovaries (oocyte donation)): the dose of progesterone is 100 mg on the thirteenth and fourteenth day of the transfer cycle; from the 15th to the 25th day of the cycle, the dose of progesterone is 200 mg, divided into two doses (morning and evening); starting from the 26th day, in case of early diagnosis of pregnancy, the dose increases gradually (every week) by 100 mg of progesterone per day, reaching a maximum of 600 mg of progesterone per day, divided into three doses; this dosage should be followed until the 60th day.
Support of the luteal phase during the in vitro fertilization cycle: treatment is carried out starting from the evening of the day of embryo transfer, at the rate of 600 mg per day in 3 divided doses (200 mg once every 8 hours).
In case of a threatened miscarriage or for the prevention of habitual miscarriages due to luteal insufficiency: 200-400 mg per day (100-200 mg per dose every 12 hours) up to 12 weeks of pregnancy.
Prevention of preterm labor in women with a short cervix or in women with a history of preterm spontaneous labor, the dose is 200 mg per day and is used in the evening before bedtime from the 22nd to the 36th week of pregnancy.
Application features
pregnant
The use of the preparation "Proginorm Gesta" is not contraindicated during pregnancy.
During the period of use of the preparation, not a single case of adverse effects of the preparation on the fetus was observed. When using the preparation in the second and third trimesters of pregnancy, monitoring of liver function is necessary.
Progesterone excretion into breast milk has not been studied in detail. Therefore, its administration should be avoided during breastfeeding.
There is evidence of the possible development of hypospadias when progestogens are used during pregnancy to prevent a typical miscarriage, or a threatened miscarriage due to luteal insufficiency, which the patient should be informed about.
Children
The preparation is not intended for use in pediatric practice.
Drivers
After taking "Proginorm Gesta" it is not recommended to drive vehicles and mechanisms.
Overdose
To date, there are no data on overdose of the preparation.
In case of overdose, it is recommended to stop the use, symptomatic treatment and measures to support and control vital functions.
For some patients, the usual dosage may be excessive as a result of persistent or new manifestations of unstable endogenous secretion of progesterone, or individual sensitivity to the preparation. In these cases, it is appropriate to assess the need to reduce the dose and / or change the frequency of taking Progynorm Gesta.
Side effects
Disorders of the reproductive system and mammary glands: frequent - change in menstruation, amenorrhea, intermittent bleeding; infrequent - mastodynia.
Disorders of the central nervous system: frequent - headaches; infrequent - drowsiness, short-term feeling of dizziness; very rare - depression.
Gastrointestinal disorders: infrequent - vomiting, diarrhea, constipation; rare - nausea.
Hepatobiliary disorders: infrequent - cholestatic jaundice.
Immune system disorders: very rare - urticaria.
Diseases of the skin and subcutaneous tissue: infrequent - itching, acne; very rare - chloasma.
There may also be manifestations of adverse reactions such as changes in libido, chest discomfort, premenstrual symptoms, hyperthermia, insomnia, alopecia, hirsutism, venous thromboembolism, pulmonary embolism, fluid retention, weight change, gastrointestinal disorders, anaphylactic reactions.
Drowsiness and / or dizziness are observed in case of concomitant hypoestrogenism. Reducing the dose of the preparation or increasing the dose of estrogen immediately eliminates these phenomena without reducing the therapeutic effect.
If the course of treatment is started very early in the beginning of the monthly cycle, especially before the 15th day, shortening of the cycle or occasional bleeding may occur.
Hypersensitivity reactions are possible, including burning, itching, flushing, and the appearance of oily discharge.
Storage conditions
Store in the original packaging at a temperature not exceeding 25°C, out of the reach of children.
Shelf life - 3 years.
Tags: Proginorm
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