Quiet oral solution 100 ml — Made in Ukraine — Free Delivery

The ability to influence the reaction rate when driving or working with other mechanisms. Due to the fact that Quiet contains ethanol and guaifenesin, its use can lead to inhibition of the reaction, which is manifested individually for each patient. Therefore, it is worth refraining from potentially hazardous activities that require increased attention, such as driving vehicles or working with other mechanisms.

Children. The preparation  is used in children over the age of 12 years.

Guayfenesin enhances the analgesic effect of paracetamol and acetylsalicylic acid and enhances the effect of alcohol and other substances that depress the central nervous system. centrally acting muscle relaxants may enhance the unwanted effects of guaifenesin, especially muscle weakness.

St. John's wort can induce the induction of isoenzymes 3A4, 1A2 and 2C9 of cytochrome P450, which can weaken the effect of other concurrently used preparations that are metabolized by these isoenzymes. This effect may also be due to the ability to induce the intestinal transport system P-glycoprotein. This interaction was first identified in healthy volunteers with the simultaneous use of indinavir and St. John's wort. It can also be expected that a similar interaction occurs with other retroviral protease inhibitors (aprenavir, nelfinavir, ritonavir, saquinavir), as well as non-nucleotide reverse transcriptase inhibitors (delaverdine, efavirenz, nevirapine), which are used in the treatment of HIV-1-positive patients. With the combined use of antiretroviral preparations and perforated St. John's wort, their effect is weakened with the possible emergence of resistance. Therefore, St. John's wort is not used simultaneously with these preparations.

Significant clinical interactions with St. John's wort have also been observed with concomitant administration of cyclosporine, digoxin, and warfarin. The interaction can lead to a decrease in the concentration of preparations in the blood plasma and, accordingly, to a decrease in the severity of the therapeutic effect. Therefore, St. John's wort cannot be used with cyclosporine. If the patient is using cyclosporine, then it is necessary to stop taking St. John's wort and, taking into account the level of cyclosporine in the blood plasma, adjust the dosage of cyclosporine.

The simultaneous use of St. John's wort with digoxin or warfarin is not recommended. If it is necessary to prescribe St. John's wort, monitor the level of digoxin in the blood plasma or control the prothrombin index during treatment with warfarin, the dose should be changed accordingly. When the dose of warfarin or digoxin is increased, the dose is not changed.

St. John's wort perforated can significantly reduce the effect of theophylline, therefore, simultaneous use is not recommended. If it is necessary to take St. John's wort, it is necessary to control the level of theophylline in the blood plasma and, if necessary, adjust the dose of theophylline without changing the dose of St. John's wort.

Concomitant use with oral contraceptives can cause menstrual irregularities, bleeding, and a decrease in the effectiveness of the preparation. Therefore, the simultaneous use of St. John's wort and oral contraceptives is not recommended.

Combination therapy with amitriptyline is not recommended.

Influence on the results of laboratory tests.

Guaifenesin can cause false positive results in diagnostic tests that detect 5-hydroxyindoleacetic acid (photometric method using nitrosonaphthol as a reagent) and vanilmandelic acid in urine. Therefore, treatment with Quiet should be discontinued 48 hours before urine collection for this analysis.

At first, it is manifested by depression of the central nervous system, drowsiness. later, these symptoms may be accompanied by nausea, mild muscle weakness, joint pain, and a feeling of heaviness in the stomach.

Treatment is exclusively symptomatic and corresponds to the general principles of overdose treatment. There is no specific antidote.

At a temperature not higher than 25 oС. do not freeze. Keep out of the reach of children.