Relief rectal ointment 28.4g — Made in Germany — Free Delivery

Pharmacodynamics

Phenylephrine hydrochloride has a local vasoconstrictor effect. This normalizes the relationship between blood flow to hemorrhoids and blood outflow from them, and also helps to reduce exudation, swelling, itching, serous discharge in hemorrhoids and other diseases of the anorectal region.

Pharmacokinetics

A preparation for topical use. Phenylephrine, which is part of it, is inactivated by tissue MAO, inactive metabolites are excreted in mucus or in small amounts by the kidneys.

Symptomatic treatment of itching, burning and discomfort that accompany hemorrhoids and other diseases of the anorectal zone, as well as with erosions, cracks, microtrauma in the anus.

Hypersensitivity to the components of the preparation, a significant increase in blood pressure, tachysystolic heart rhythm disturbances, decompensated heart failure, cardiac conduction disorders, severe renal and hepatic failure, thyrotoxicosis, acute pancreatitis, simultaneous use with MAO inhibitors (MAO) or within 15 days after discontinuation treatment with MAO inhibitors, thromboembolic disease, granulocytopenia.

Method of administration and dosage

For adults and children over 12 years of age, use the preparation after hygiene procedures. Remove the protective cap from the applicator. Attach the applicator to the tube and squeeze out enough ointment to lubricate the applicator. Carefully apply the ointment through the applicator to the affected areas outside or inside the anus in an amount sufficient to treat the affected areas, up to 4 times a day, preferably in the evening, in the morning or after each bowel movement. Apply until the symptoms of the disease disappear. Rinse the applicator thoroughly after each use and place it in the protective cap. Do not use if protective coating is missing or damaged.

Active ingredient: phenylephrine hydrochloride.

1 g of ointment contains phenylephrine hydrochloride 2.5 mg.

Excipients: mineral oil, tocopherol, thyme oil, corn oil, glycerin, white soft paraffin, methyl parahydroxybenzoate (E 218), propyl parahydroxybenzoate (E 216), lanolin, benzoic acid (E 210), lanolin alcohol, wax, purified water white.

In medical practice, it is not described, there are no data on systemic, including toxic, reactions of the body in response to rectal administration of Relief®. However, in case of an overdose, an increase in the manifestations of adverse reactions is possible, especially with prolonged use. Arterial hypertension, pain and discomfort in the heart, palpitations, shortness of breath, noncardiogenic pulmonary edema, agitation, convulsions, sleep disturbances, anxiety, paranoia, irritability, psychosis with hallucinations, weakness, anorexia, nausea, vomiting, oliguria, urinary retention, redness of the face, feeling of coldness in the extremities, paresthesia, hypersensitivity, hyperglycemia, hypokalemia, reduced blood flow to vital organs, which can lead to a deterioration in the blood supply to the kidneys, metabolic acidosis, an increase in the load on the heart due to an increase in the total resistance of peripheral vessels. Treatment is symptomatic.

This preparation is usually well tolerated, but in rare cases, phenylephrine hydrochloride-related adverse reactions may occur.

From the side of the cardiovascular system: reflex bradycardia, arrhythmia, possible cardiac arrhythmias, increased blood pressure.

From the immune system: allergic reactions, including cross-reactions in case of allergy to other sympathomimetics, which may manifest as rash, itching, angioedema.

From the endocrine system: an increase in symptoms of hyperthyroidism.

Skin and subcutaneous tissue disorders: contact dermatitis.

From the nervous system: dizziness, nervousness, headache, tremors, insomnia, fear, feeling of blood rush to the face.

At the site of application, possible irritation, hyperemia, rash, itching, edema, moderate pain / burning with injury or bleeding from the anus.

Methylparaben and propyl parahydroxybenzoate can cause allergic reactions (possibly delayed) and, in some cases, bronchospasm. Lanolin can cause local skin reactions (eg contact dermatitis). Benzoic acid is mildly irritating to skin, eyes and mucous membranes.

Use during pregnancy or lactation

Since the safety of using the preparation  Relief ® (phenylephrine) during pregnancy has not been studied, the use of the preparation  is possible if, in the opinion of the doctor, the benefit to the mother outweighs the potential risk to the fetus / child.

Pregnant women should consult a doctor before using the preparation.