Revival 60mg 30 gastro-resistant capsules — Made in Cyprus — Free Delivery

(Revival 60mg)
Revival 60mg 30 gastro-resistant capsules — Made in Cyprus — Free Delivery
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Medochemie Brand: Medochemie
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Description Revival 60mg 30 gastro-resistant capsules — Made in Cyprus — Free Delivery

Product description 

Revival capsules are indicated for:
  • Treatment of major depressive disorder.
  • Treatment of diabetic peripheral neuropathic pain.
  • Treatment of generalized anxiety disorder.

Compound

Active ingredient: duloxetine hydrochloride;
1 gastroresistant hard capsule contains duloxetine hydrochloride 33.68 mg, equivalent to duloxetine 30 mg, or duloxetine hydrochloride 67.35 mg, equivalent to duloxetine 60 mg;
Excipients: spherical sugar (sucrose, corn starch), hypromellose 2910/5mPa.s, crospovidone type A, sucrose, hypromellose acetate succinate, triethyl citrate (E 1505), talc, macrogol 8000, titanium dioxide (E 171);
Capsule shell (for 30 mg capsules):
  • The composition of the capsule shell: titanium dioxide (E 171), gelatin, patent blue V (E 131), sodium lauryl sulfate, carmoisine (E 122), purified water;
Capsule shell (for 60 mg capsules):
  • The composition of the capsule shell: titanium dioxide (E 171), gelatin, sodium lauryl sulfate, erythrosin (E 127), iron oxide red (E 172), iron oxide black (E 172), purified water.

Contraindications

Hypersensitivity to duloxetine or to any excipients of the preparation.
Simultaneous use with non-selective irreversible MAO inhibitors (MAO) or for at least 14 days after stopping treatment with MAO inhibitors. Given the half-life of duloxetine, MAO inhibitors should not be administered for at least 5 days after discontinuation of duloxetine treatment.
Simultaneous use with fluvoxamine, ciprofloxacin or enoxacin (strong inhibitors of CYP1A2) due to an increase in the concentration of duloxetine in the blood plasma.
Unstable arterial hypertension, which can provoke a hypertensive crisis.
End-stage renal failure (creatinine clearance <30 ml/min).
Liver disease, which can lead to liver failure.

Mode of application

Major depressive disorder. The initial and recommended maintenance dose is 60 mg once a day, regardless of food intake. Doses greater than 60 mg once daily, up to a maximum of 120 mg daily, have been evaluated for safety. However, there is no clinical evidence that patients who do not respond to the initial recommended dose may benefit from a dose increase.
Therapeutic response is usually observed after 2-4 weeks of treatment.
After a sustained antidepressant effect, it is recommended to continue treatment for several months to avoid relapse. In patients who respond to duloxetine and with a history of recurrent episodes of major depression, further long-term treatment at a dose of 60-120 mg daily should be considered.

Application features

pregnant
The use of the preparation during pregnancy is recommended only if the expected benefit to the pregnant woman outweighs the potential risk to the fetus.
Children
The safety and efficacy of duloxetine in children have not been studied, so the preparation is contraindicated in this age group of patients.
Drivers
During treatment, patients should refrain from potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Overdose

Data on duloxetine overdose are limited. There are reports of taking large doses (up to 1400 mg) of duloxetine alone or in combination with other preparations, which did not have fatal outcomes. Overdose symptoms (mainly when combined with other preparations) included drowsiness, coma, serotonin syndrome, epileptic seizures, vomiting and tachycardia.
Treatment. Specific antidotes are unknown. When serotonin syndrome occurs, specific treatment is necessary (using cyproheptadine and / or temperature control). Airway patency should be checked. Cardiac and vital signs monitoring is recommended, along with appropriate symptomatic and supportive measures. Gastric lavage may be appropriate if performed immediately after taking the preparation. Activated charcoal reduces the absorption of the preparation. Duloxetine has a large volume of distribution in the body, and therefore forced diuresis, hemoperfusion and exchange perfusion are unlikely to be useful.

Side effects

Dizziness, nausea and headache have been reported as adverse symptoms upon discontinuation of duloxetine. Sensory disturbances, sleep disturbances, agitation or anxiety, tremors, irritability, diarrhea, and hyperhidrosis have also been reported upon discontinuation of duloxetine.
From the endocrine system: hypothyroidism.
From the immune system: anaphylactic reactions, hypersensitivity.
On the part of metabolism: decreased appetite, hyperglycemia, dehydration, hyponatremia, syndrome of inappropriate secretion of antidiuretic hormone.
On the part of the psyche: insomnia, agitation, decreased libido, anxiety, abnormal visions and abnormal orgasm, sleep disorders, bruxism, disorientation, apathy, suicidal thinking, mania, hallucinations, aggression and malice, suicidal behavior.
From the nervous system: headache, drowsiness, dizziness, tremor, paresthesia, myoclonus, akathisia, nervousness, attention disorders, lethargy, dyskinesia, taste disturbances, restless legs syndrome, poor sleep, serotonin syndrome, convulsions, extrapyramidal disorders ..
From the dock of the organs of vision: blurry image, mydriasis, visual disturbances, dry eyes, glaucoma.
On the part of the hearing organs: ringing in the ears, vertigo, pain in the ears.
From the side of the cardiovascular system: palpitations; tachycardia hot flashes; supraventricular arrhythmia; fibrillation, more often atrial; arterial hypertension; increased blood pressure; orthostatic hypotension; loss of consciousness; sensation of coldness in the extremities; hypertensive crisis.
From the respiratory system: yawning, oropharyngeal pain, a feeling of constriction in the throat, epistaxis.
From the digestive tract: nausea, vomiting, dyspepsia, flatulence, abdominal pain, constipation, diarrhea, gastrointestinal bleeding, gastroenteritis, belching, gastritis, stomatitis, bad breath, blood in the stool, dry mouth.

Interaction

Preparations acting on the central nervous system. When taking duloxetine in combination with other preparations that act on the central nervous system, especially with a similar mechanism of action, including alcohol and sedative preparations, certain precautions must be observed.
MAO inhibitors. Duloxetine should not be co-administered with non-selective irreversible MAO inhibitors due to the risk of serotonin syndrome. When taking reversible selective monoamine oxidase inhibitors (MAOIs), such as moclobemide, the risk of serotonin syndrome is less, but the use of this combination is not recommended.
Medicines containing duloxetine. Co-administration with other medicinal products containing duloxetine should be avoided.
Preparations containing St. John's wort. When used together, adverse reactions often occur.

Storage conditions

Store below 25°C in original packaging.
Keep out of the reach of children.
Shelf life - 3 years.

Tags: Revival

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