Trachisan 20 lozenges — Made in Germany — Free Delivery

Pharmacological properties

Trachisan contains a combination of antimicrobial and local anesthetic agents.

Tyrothricin is a mixture of various cyclic and linear (aliphatic) polypeptides that have an antibacterial effect. The mixture contains up to 70–80% tyrocidin, an alkaline cyclic decapeptide, and 20–30% gramicidin, a neutral linear pentadecapeptide.

Tyrocidin leads to the release from bacterial cells of substances containing nitrogen and phosphorus, which, like cationic detergents, destroy the osmotic barrier of the bacterial cell membrane. Tyrocidin has a bactericidal effect on growing and dividing microorganisms.

Gramicidin creates cation-conducting channels in the bacterial cell membrane, leading to a change in the intracellular concentration of cations and cytolysis. The gramicidin component contributes to the further separation of the processes of tissue respiration and oxidative phosphorylation.

The spectrum of action of tyrothricin extends to gram-positive cocci, bacteria and some types of fungi, such as Candida albicans.

Unlike antibiotics, when using tyrothricin, cross-resistance of microorganisms is not noted. This property is due to the special mechanism of action of tyrothricin.

Chlorhexidine and its salts have a broad spectrum of antimicrobial activity against gram-positive and gram-negative bacteria.

The mechanism of action of chlorhexidine is based on its affinity for the cell membrane of microorganisms, the properties of which change due to contact with the active substance.

The lipophilic groups of chlorhexidine cause disaggregation of the lipoprotein membrane of the cell membrane, disrupt the osmotic balance in the cells, which destroys the cytoplasmic membrane of the pathogen cell.

The effect on some gram-negative bacteria (Pseudomonas, Proteus), yeast, dermatophytes and mycobacteria is insignificant. Chlorhexidine is ineffective against fungal spores, putrefactive fungi, viruses.

Lidocaine hydrochloride is an amide-type local anesthetic. The preparation causes a blockade of the sodium channels of the nerve fiber, as a result of which the process of depolarization of the nerve cell membrane through the active potential is disrupted. In this case, the transmission of excitation in the fibers of the sensory nerves is blocked.

With prolonged use (longer than several months), the effectiveness of the preparation decreases, which is apparently due to changes in the bacterial spectrum of the microflora of the oral cavity and tooth surface.

Indications

Inflammatory and infectious diseases of the oral cavity and pharynx, such as stomatitis, gingivitis, periodontitis, glossitis, tonsillitis, pharyngitis, and other conditions accompanied by impaired swallowing. for the prevention of infections before and after surgery in the areas of the oral cavity and pharynx (tooth extraction, surgical treatment of the gums, tonsillectomy).

Application

Take 1 tablet of trachisan, dissolving in the mouth every 2 hours. The daily dose for adults and children over the age of 12 is 8 tablets; for children aged 4 to 12 years - 6 tablets. as a rule, the symptoms of the disease disappear after a few days, but in order to achieve a stable therapeutic effect, it is recommended to continue therapy for another 2-3 days. if the patient's condition does not improve within 5 days of using the preparation, a doctor's consultation is necessary regarding further treatment.

Continuous use of Trachisan lozenges without a doctor's prescription can last no more than 2 weeks.

Children. Not recommended for use in children under 4 years of age, since the preparation must be resorbed.

Contraindications

Hypersensitivity to the components of the preparation or to other amide local anesthetic preparations. erosive and desquamative changes in the oral mucosa, large fresh wounds in the mouth and pharynx, fructose intolerance.

Side effects

In rare cases, hypersensitivity reactions are possible, including: local irritation, swelling of the pharynx, swelling of the face, itching, hives, skin rashes, or shortness of breath.

Perhaps a short-term change in taste, temporary numbness of the tongue, which disappear on their own after stopping the preparation. With prolonged use in isolated cases, slight yellow or light brown staining of teeth, dental fillings and prostheses or tongue is possible, you can get rid of it with the help of oral hygiene.

Special instructions

Trakhisan does not contain sugar and therefore does not contribute to the occurrence of dental caries. the preparation can be used in patients with diabetes mellitus, using the recalculation of the sweetener sorbitol per xe (0.69 g of sorbitol corresponds to 0.057 xe).

During pregnancy and breastfeeding. There have been no reports of the negative effect of the preparation during pregnancy and lactation. However, no special studies were carried out in this category of patients. Therefore, before using the preparation, the doctor must weigh the risk / benefit ratio for this group of patients.

The ability to influence the reaction rate when driving or working with other mechanisms. Does not affect.

Interactions

Not identified.

Overdose

Overdose cases are not described. in case of accidental use of an excessive number of tablets, it is recommended to rinse the stomach. symptomatic treatment.

Storage conditions

At a temperature not exceeding 25 ° c in a dry place.