Warfarex 5mg 30 tablets — Made in Latvia — Free Delivery

Product description

Warfarex tablets are indicated for:

• prevention and treatment of deep vein thrombosis and pulmonary embolism;
• secondary prevention of myocardial infarction and prevention of thromboembolic complications (stroke or systemic embolism) after myocardial infarction;
• prevention of thromboembolic complications in patients with atrial fibrillation, heart valve lesions or prosthetic heart valves;
• prevention of rapid ischemic attacks and stroke.

Structure

Active substance: warfarin;

1 tablet contains 3 mg of sodium warfarinate (as sodium warfarinate clathrate);

Excipients: lactose, monohydrate; microcrystalline cellulose; crospovidone; magnesium stearate; indigo carmine (E 132) (for 3 mg tablets) and crimson 4R (E 124) (for 5 mg tablets).

Contraindications

• hypersensitivity to warfarin or to any excipient of the preparation;
• clinically established bleeding;
• bleeding tendency (von Willebrand disease, hemophilia, thrombocytopenia and platelet dysfunction);
• in order to avoid the development of the risk of severe bleeding within 72 hours after major surgical interventions, within 48 hours in the postpartum period;
• severe renal and hepatic impairment or cirrhosis of the liver;
• untreated or uncontrolled arterial hypertension;
• recent intracranial bleeding; conditions causing intracranial bleeding, for example, cerebral artery aneurysm, aortic aneurysm;
• tendency to fainting (falling);
• operations in the central nervous system or on the eyes;
• gastrointestinal or renal bleeding and its complications;
• diverticulosis;
• malignant tumors;
• varicose veins of the esophagus;
• infective endocarditis, pericarditis, or pericardial effusion;
• a condition in which therapy cannot be carried out safely enough (for example, dementia, psychosis, alcoholism);
• lumbar puncture.

Mode of application

Warfarex must be used at the same time.

The dose of Warfarex is determined by the doctor for each patient individually, guided by the INR indicators of prothrombin.

Target INR range for oral anticoagulant therapy.

Prevention of thromboembolic complications in patients with prosthetic heart valves: INR - 2.5-3.5. Other indications: INR - 2.0–3.0.

Application features

Pregnant

Contraindicated.

Children

Anticoagulant therapy in children should be carried out as directed and under the supervision of pediatricians.

Drivers

Does not affect.

Overdose

Symptoms: bleeding, bleeding.

Treatment: In mild cases, with gradual overdose, it is usually sufficient to reduce the dose or stop treatment with warfarin until the INR returns to the target level. In acute preparation overdose, emptying the stomach is not recommended due to the risk of bleeding. Activated charcoal should be reused to avoid absorption and enterohepatic recirculation of warfarin. When using activated charcoal parenterally (i / v), vitamin K should be administered. If bleeding develops, the effect of warfarin should be discontinued using vitamin K (intravenously at a dose of 5-10 mg), coagulation factor concentrate, or fresh frozen plasma. If necessary, further anticoagulation should avoid the use of vitamin K at a dose of more than 10 mg. Otherwise, the patient may be resistant to warfarin therapy for 2 weeks.

Side effects

From the nervous system: subdural hematoma, fever.

From the circulatory and hematopoietic system: hemorrhage, coumarin necrosis, purple staining of the toes, purpura, eosinophilia, vasculitis, anemia, decreased hematocrit.

From the respiratory system, chest and mediastinum: tracheal calcification, hematorx.

From the gastrointestinal tract: nausea, vomiting, vomiting of blood, diarrhea, abdominal pain, gastrointestinal bleeding, rectal bleeding, melena.

From the hepatobiliary system: a reversible increase in the activity of liver enzymes, cholestatic hepatitis, jaundice.

Skin and subcutaneous tissue disorders: reversible alopecia, rash, urticaria, pruritus, eczema, erythematous edema of the skin, leading to ecchymosis, heart attack and skin necrosis.

From the genitourinary system: hematuria, priapism.

General: allergic reactions (usually in the form of skin rashes), nephritis, urolithiasis, tubular necrosis.

Interaction

Fibrinolytics such as streptokinase and alteplase are contraindicated in patients taking warfarin.

It is necessary to avoid the simultaneous use of warfarin or use it with caution under close clinical and laboratory supervision with thrombin inhibitors, unfractionated heparins and their derivatives, heparin with low molecular weight, fondaparin, rivaroxaban, antagonists of glycoprotein IIb / IIIa receptors, serotoramine reverse capture, inhibitors

Excessive alcohol consumption against the background of liver failure potentiates the effect of warfarin. The quinine in Tonic water can also increase the effect of warfarin.

Storage conditions

Store in a dark place at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

The shelf life is 5 years.