Acic aciclovir cream 5% (acyclovir), 2g — Made in Poland by Sandoz — Free Delivery

Pharmacodynamics. acyclovir is an antiviral preparation for topical use, highly active in vitro against herpes simplex virus types 1 and 2. the toxic effect on the cells of the host organism is minimal. penetrating into cells infected with the herpes virus, acyclovir is phosphorylated to form an active compound - acyclovir triphosphate. the first step in this process depends on the presence of virus-coded thymidine kinase. Acyclovir triphosphate acts as an inhibitor and substrate for viral DNA polymerase, preventing further viral DNA synthesis without affecting normal cellular processes.

Pharmacokinetics. Pharmacokinetic studies have shown a minimum level of systemic absorption of acyclovir after repeated topical application of the cream.

Treatment of infections of the lips and face caused by the herpes simplex virus (herpes labialis).

The preparation is intended for external use only.

For adults and children under the age of 12, apply Acik® cream 5 times a day (with an interval of 4 hours), except at night. It is important to start treatment as soon as possible at the onset of the infection, ideally during the prodromal or erythema stage.

Treatment should last at least 4 days. If no healing is noted, treatment can be continued for up to 10 days. If the symptoms of the disease do not disappear after 10 days of treatment, the patient should consult a doctor.

Hypersensitivity to acyclovir, valacyclovir, propylene glycol or other components of the cream.

In some patients, when using the cream, a temporary, fast-passing sharp or burning pain may appear. in about 5% of patients, slight drying and flaking of the skin was noted. a small proportion of patients reported erythema (redness) and itching. very rare cases of contact dermatitis have been reported after applying the cream. in susceptibility tests, these cases were more likely to be associated with the components of the cream base than with acyclovir. there are isolated reports of immediate hypersensitivity reactions, including angioedema due to topical application of acyclovir.