Aciclovir (acyclovir) 400 Stada 35 tablets — Made in Germany — Free Delivery

(Aciclovir 400 )
Aciclovir (acyclovir) 400 Stada 35 tablets — Made in Germany — Free Delivery
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STADA Brand: STADA

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Description Aciclovir (acyclovir) 400 Stada 35 tablets — Made in Germany — Free Delivery

Product description

Acyclovir 400 Stada® tablets are used for the following indications:

  • treatment of viral infections of the skin and mucous membranes caused by the herpes simplex virus, including primary and recurrent genital herpes;
  • suppression (prevention of recurrence) of infections caused by the herpes simplex virus in patients with normal immunity;
  • prevention of infections caused by the herpes simplex virus in patients with immunodeficiency;
  • treatment of infections caused by the Varicella zoster virus (chickenpox and herpes zoster).

Composition

The active ingredient is acyclovir (one tablet contains 400 mg acyclovir).

Excipients: microcrystalline cellulose, anhydrous colloidal silicon dioxide, sodium starch glycolate (type A), copolyvidone, magnesium stearate.

Contraindications

Hypersensitivity to acyclovir, valacyclovir or to any other components of the preparation.

Mode of application

The tablet should be taken whole with water. When using high doses of acyclovir, an adequate level of body hydration should be maintained.

Adults

For the treatment of infections caused by the herpes simplex virus, it is necessary to take acyclovir tablets at a dose of 200 mg 5 times a day at approximately 4-hour intervals, with the exception of the night period. Treatment should be continued for 5 days, but in the case of a severe primary infection, it can be continued. For patients with severe immunodeficiency (for example, after bone marrow transplantation) or for patients with reduced intestinal absorption, the dose can be doubled to 400 mg, or the appropriate dose for intravenous administration can be used. Treatment should be started as early as possible after the onset of the infection. In the case of recurrent herpes, it is better to start treatment in the prodromal period or after the first signs of skin lesions appear.

Prevention of recurrence (suppressive therapy) of infections caused by the herpes simplex virus. In patients with normal immunity, to prevent recurrence of herpes simplex virus infections, take 200 mg tablets 4 times a day at 6-hour intervals. For convenience, most patients can take 400 mg of acyclovir 2 times a day at 12-hour intervals. Treatment will be effective even after reducing the dose of acyclovir to 200 mg, which should be taken 3 times a day with an 8-hour interval or even 2 times a day with a 12-hour interval. In some patients, a radical improvement is observed after taking a daily dose of 800 mg acyclovir. To monitor possible changes in the natural course of the disease, therapy with acyclovir should be interrupted periodically at intervals of 6-12 months.

Prevention of infections caused by the herpes simplex virus. For the prevention of infections caused by the herpes simplex virus, in patients with immunodeficiency, 200 mg tablets should be taken 4 times a day with a 6-hour interval. For patients with significant immunodeficiency (for example, after bone marrow transplantation) or for patients with reduced intestinal absorption, the dose can be doubled to 400 mg, or the appropriate dose for intravenous administration can be used. The duration of prophylaxis depends on the length of the risk period.

For the treatment of infections caused by the viruses of chickenpox and herpes zoster, you need to take 800 mg tablets 5 times a day at 4-hour intervals, with the exception of the night period. Treatment should continue for 7 days. Patients with severe immunodeficiency (for example, after bone marrow transplantation) or patients with reduced absorption in the intestine are better off using intravenous administration. Treatment should be started as early as possible after the onset of the disease, the result will be better if the treatment is started immediately after the appearance of the rash.

Children

For the treatment and prevention of infections caused by the herpes simplex virus in children with immunodeficiency at the age of 2 years, doses can be used as for adults.

For the treatment of chickenpox in children over 6 years old, prescribe 800 mg of acyclovir 4 times a day, children aged 2 to 6 years can receive 400 mg of acyclovir 4 times a day. The duration of treatment is 5 days.

A more accurate dose can be calculated by the child's body weight: 20 mg / kg of body weight per day (not to exceed 800 mg) of acyclovir in 4 divided doses.

Children under 2 years of age should not use this dosage form of the preparation.

Application features

Pregnant

There was no increase in the number of congenital defects in children whose mothers used acyclovir during pregnancy, compared with the general population. However, it is necessary to use acyclovir tablets only when the potential benefit of the preparation to the mother outweighs the possible risk to the fetus.

When taken orally 200 mg of acyclovir 5 times a day, acyclovir penetrates into breast milk at concentrations of 0.6-4.1% of the corresponding level of acyclovir in blood plasma. Potentially, a child fed with this milk can assimilate acyclovir at a dose of up to 0.3 mg / kg of body weight per day. Therefore, prescribing acyclovir for breastfeeding should be done with caution, taking into account the risk / benefit ratio.

Drivers

When deciding on the possibility of driving a car or other mechanisms, the clinical status of the patient and the profile of side effects of the preparation should be taken into account. Studies of the effect of acyclovir on the reaction rate when driving vehicles or working with other mechanisms have not been carried out. In addition, the pharmacology of acyclovir does not give reason to expect any negative effects.

Overdose

Symptoms

Acyclovir is only partially absorbed from the gastrointestinal tract. Accidental internal intake of up to 20 g of acyclovir by patients without the occurrence of a toxic effect has been reported. Accidental repeated oral overdose of oral acyclovir over several days causes gastroenterological (such as nausea and vomiting) and neurological symptoms (headache and confusion). In case of an overdose of intravenous acyclovir, the level of serum creatinine and blood urea nitrogen increases, which leads to renal failure. Overdose neurological manifestations can be confusion, hallucinations, agitation, convulsions, and coma.

Treatment

The patient must be carefully examined to identify symptoms of intoxication. Since acyclovir is well removed from the blood by hemodialysis, the latter should be used in case of overdose.

Side effects

On the part of the blood and lymphatic system: anemia, thrombocytopenia, leukopenia.

From the immune system: anaphylaxis.

Mental and nervous system disorders: headache, dizziness, agitation, confusion, tremor, ataxia, dysarthria, hallucinations, psychotic symptoms, convulsions, drowsiness, encephalopathy, coma.

The above neurological reactions are generally reversible and usually occur in patients with renal insufficiency or other risk factors.

From the respiratory system and chest organs: shortness of breath.

From the digestive system: nausea, vomiting, diarrhea, abdominal pain.

From the hepatobiliary system: a reversible increase in the level of bilirubin and liver enzymes, jaundice, hepatitis.

On the part of the skin and subcutaneous tissue: itching, rash (including photosensitivity), urticaria, frequent diffuse hair loss (since hair loss can be associated with a large number of diseases and preparations, no clear connection with acyclovir has been found), angioedema.

On the part of the kidneys and urinary system: increased levels of urea and blood creatinine, acute renal failure, pain in the kidneys.

Kidney pain can be associated with renal failure and crystalluria.

Storage conditions

Keep out of the reach of children. Does not require special storage conditions.

The shelf life is 5 years.

Tags: Aciclovir

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