Before starting therapy with the preparation Augmentin 1000, it is necessary to accurately determine the presence of hypersensitivity reactions to penicillins, cephalosporins or other allergens in the anamnesis.

Serious and sometimes even fatal cases of hypersensitivity (anaphylactic reactions) occur in patients during penicillin therapy. These reactions are more likely in individuals with similar reactions to penicillin in the past (see Adverse Reactions). In case of allergic reactions, Augmentin 1000 therapy should be stopped and alternative therapy should be started.

If it is proven that the infection is caused by microorganisms sensitive to amoxicillin, it is necessary to consider the possibility of switching from the combination of amoxicillin / clavulanic acid to amoxicillin according to official recommendations.

This dosage form of the preparation Augmentin 1000 should not be used if there is a high probability that the pathogens are resistant to β-lactams, and should not be used to treat pneumonia caused by penicillin strains of S. pneumoniae.

Augmentin 1000 should not be prescribed if infectious mononucleosis is suspected, since cases of scabies rash have been observed with amoxicillin in this category of patients.

Long-term use of the preparation can cause excessive growth of microflora insensitive to Augmentin 1000.

The development of erythema multiforme associated with pustules at the beginning of treatment may be a symptom of acute generalized exanthematous pustulosis (see Side effects). In this case, it is necessary to stop the treatment, and further use of amoxicillin is contraindicated.

Augmentin 1000 The following should be prescribed with caution to patients with signs of liver failure (see USE, Contraindications, side effects). Adverse reactions from the liver occurred mainly in men and elderly patients and were associated with long-term treatment with the combined preparation amoxicillin / clavulanic acid. Such phenomena have been reported very rarely in children. In all groups of patients, symptoms usually occurred during or immediately after treatment, but in some cases they appeared several months after stopping therapy. In general, these phenomena were reversible. Liver side effects can be severe and very rarely fatal. They have always occurred in patients with severe concomitant diseases or with the simultaneous use of preparations that can adversely affect the liver (see Side effects).

With the use of almost all antibacterial preparations, the occurrence of antibiotic-associated colitis, from mild to life-threatening, has been reported (see Side Effects). It is important to keep this in mind when patients develop diarrhea during or after antibiotic use. In case of development of antibiotic-associated colitis, Augmentin 1000 Next therapy should be stopped immediately and appropriate treatment started.

Rarely, patients taking Augmentin 1000 and oral anticoagulants may experience an increase in prothrombin time (an increase in the international normalized ratio - INR). When taking anticoagulants at the same time, appropriate control of laboratory indicators is necessary. There may be a need to adjust the dose of oral anticoagulants to maintain the required level of coagulation.

For patients with impaired renal function, it is necessary to adjust the dose according to the degree of renal insufficiency (see Method of use).

Crystalluria can very rarely be observed in patients with reduced urinary excretion, mainly with parenteral administration of the preparation. Therefore, to reduce the risk of crystalluria during treatment with high doses of amoxicillin, maintain fluid balance in the body (see Conditions and shelf life).

During treatment with amoxicillin, enzymatic reactions with glucose oxidase should be used to determine the level of glucose in the urine, since other methods can give false positive results.

The presence of clavulanic acid in the preparation can cause nonspecific binding of IgG and albumin on the membranes of erythrocytes, as a result of which a false positive result is possible when conducting the Coombs test.

There have been reports of false-positive Aspergillus test results in patients receiving amoxicillin/clavulanic acid (using the Bio-Rad Laboratories Platelis Aspergillus EIA test). Therefore, such positive results in patients receiving amoxicillin / clavulanic acid should be interpreted with caution and confirmed by other diagnostic methods.