Biseptol 100mg/20mg, 20 tablets — Made in Poland by Adamed — Free Delivery
(Biseptol )
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Description Biseptol 100mg/20mg, 20 tablets — Made in Poland by Adamed — Free Delivery
Product description
Biseptol tablets are used to treat infections caused by pathogens sensitive to the preparation, in cases where the benefit of such treatment exceeds the possible risk (it is necessary to decide whether only one antibacterial agent can be used):
- infections of the ENT organs and respiratory tract: sinusitis, otitis media, acute and chronic bronchitis, bronchiectasis, pneumonia (including caused by Pneumocystis carinii), pharyngitis, tonsillitis (for infections caused by β-hemolytic streptococci of group A, the frequency of eradication is not entirely sufficient );
- kidney and urinary tract infections: acute and chronic cystitis, pyelonephritis, urethritis, prostatitis, soft chancre;
- infections of the digestive tract: typhoid fever and paratyphoid fever, shigellosis (caused by sensitive strains of Shigella flexneri and Shigella sonnei, if antibacterial therapy is indicated), "traveler's" diarrhea caused by enterotoxic strains of Escherichia coli, cholera (in addition to restoring fluid and electrolytes);
- other bacterial infections: acute and chronic osteomyelitis, brucellosis, nocardiosis, actinomycosis, toxoplasmosis, South American blastomycosis.
Storage
Active ingredients: sulfamethoxazole, trimethoprim (co-trimoxazole);
1 tablet of 100 mg / 20 mg contains sulfamethoxazole 100 mg, trimethoprim 20 mg;
1 tablet 400 mg / 80 mg contains sulfamethoxazole 400 mg trimethoprim 80 mg;
Excipients: potato starch, talc, magnesium stearate, polyvinyl alcohol.
Contraindication
- hypersensitivity to trimethoprim and sulfamethoxazole (including sulfonamide derivatives, sulfonylurea antidiabetic agents, as well as thiazide diuretics) and other components of the preparation;
- acute hepatitis, impaired liver function, severe liver failure, including diagnosed damage to the liver parenchyma, porphyria;
- blood diseases, disorders of hematopoiesis, severe hematological disorders, megaloblastic anemia caused by folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency (risk of hemolysis);
- severe renal insufficiency, which is characterized by a creatinine clearance of less than 15 ml / minute, if it is not possible to determine the concentration of the preparation in the blood plasma (with the exception of cases of hemodialysis);
- the preparation is contraindicated for patients undergoing chemotherapy;
- the preparation cannot be prescribed in combination with dofetilide.
Application method
Adults and children over 12 years old. Usually, the initial dose is two tablets 2 times a day (morning and evening). Tablets should be taken after a meal, drinking plenty of liquid. For severe infections, higher daily doses can be prescribed - up to 3 tablets 2 times a day. For maintenance therapy lasting more than 14 days, it is recommended to take one tablet 2 times a day.
Children 6-12 years old. The recommended daily dose for children is 6 mg of trimethoprim and 30 mg of sulfamethoxazole per kg of body weight. This dose should be divided into two doses.
The recommended daily dose for children aged 6 to 12 years is one tablet 2 times a day.
Duration of the course of treatment: for acute infections, with the exception of gonorrhea, the treatment should last at least 5 days or another 2 days after the disappearance of the symptoms of the disease. A three-day course of treatment may be sufficient for women with uncomplicated acute cystitis. However, children with this disease are recommended to use the preparation for 5-7 days.
Features of application
pregnant
This preparation cannot be used during pregnancy and breastfeeding.
Children
The preparation is used to treat children older than 6 years.
Drivers
The preparation does not cause a decrease in psychophysical activity and the ability to drive vehicles and operate mechanisms. If side effects from the nervous system develop during treatment (dizziness, headache, convulsions, nervousness, feeling of fatigue), which can cause a decrease in the speed of psychomotor reactions, you should avoid driving vehicles and working with complex mechanisms.
Overdose
It is not known what dose of the preparation can be life-threatening. With an overdose of sulfonamides, there is a lack of appetite, colic pain, nausea, vomiting, diarrhea, dizziness, headache, drowsiness, loss of consciousness. Fever, hematuria and crystalluria may appear, with chronic overdose, inhibition of bone marrow functions, hepatitis may develop. Acute overdose of trimethoprim may cause nausea, vomiting, dizziness, headache, mental depression, confusion, suppression of bone marrow function.
If symptoms of overdose appear, it is necessary to stop using the preparation, induce vomiting, take a large amount of liquid if diuresis is insufficient and kidney function is normal. Urine acidification will accelerate the excretion of trimethoprim, but will increase the risk of sulfonamide crystallization in the kidneys. The patient's blood count, serum electrolytes, and other biochemical indicators should be monitored. If bone marrow damage or symptoms of hepatitis occur, the usual treatment in such cases should be applied. Hemodialysis is ineffective. Peritoneal dialysis is ineffective.
In case of chronic poisoning, suppression of spinal cord function is observed, manifesting as thrombocytopenia, leukopenia, or megaloblastic anemia. In this case, leucovorin (5-15 mg per day) should be used.
Side effects
The most frequent adverse reactions during treatment with the preparation are from the digestive tract (nausea, vomiting, lack of appetite) and skin allergic reactions (rash, urticaria).
Interaction
Zidovudine: in some cases, the simultaneous use of co-trimoxazole and zidovudine increases the risk of hematological disorders caused by Biseptol. If it is necessary to use co-trimoxazole and zidovudine simultaneously, blood parameters should be monitored.
Folic acid Supplementation with folic acid has been shown to affect the antimicrobial efficacy of trimethoprim-sulfamethoxazole. This was observed in the prevention and treatment of pneumonia caused by Pneumocystis jiroveci.
Storage conditions
Store at a temperature not higher than 25°C.
Keep out of the reach of children.
Shelf life - 5 years.
Tags: Biseptol
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