Darsil 22.5mg 100 tablets — Made in Ukraine — Free Delivery

(Darsil)
Darsil 22.5mg 100 tablets — Made in Ukraine — Free Delivery
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Darnitsa Brand: Darnitsa
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Description Darsil 22.5mg 100 tablets — Made in Ukraine — Free Delivery

Pharmacological properties

Pharmacodynamics. The active ingredient of the preparation darsil - silymarin - is obtained from the extract of the fruits of the milk thistle plant silybum marianum.
Bioactive components of silymarin neutralize free radicals in the liver, prevent the destruction of cellular structures, in particular, stabilize the membranes of hepatocytes. In damaged hepatocytes, they stimulate the synthesis of structural and functional proteins and phospholipids due to specific stimulation of RNA polymerase, prevent the loss of cell components (transaminases), and accelerate the regeneration of liver cells. They inhibit the penetration of some poisons into hepatocytes, in particular, the poison of the mushroom pale toadstool. They significantly reduce the activity of LPO in the membranes of hepatocytes, thereby contributing to their strengthening.
They improve the general condition in patients with liver diseases, reduce subjective sensations (weakness, a feeling of heaviness in the right hypochondrium). Contributes to the normalization of biochemical parameters of the functional state of the liver (activity of transaminases, γ-glutamylaminotransferase, alkaline phosphatase, bilirubin level).
Pharmacokinetics. After oral administration, silymarin is slowly but not completely absorbed in the digestive tract. Practically does not bind to blood plasma proteins. It is metabolized in the liver by conjugation to form sulfates and glucuronides. It is excreted mainly with bile, in the small intestine it is again absorbed into the systemic circulation, making multiple gradually decaying enterohepatic circulation. T½ is about 6 hours. Virtually does not accumulate in the body.

Indications

Toxic liver damage: for the maintenance treatment of patients with chronic inflammatory liver disease or liver cirrhosis.

Application

Darsil tablets are taken orally after meals without chewing, drinking plenty of fluids.
Adults and children over the age of 12 years: in cases of mild and moderate severity, the preparation is used in a dose of 1-2 tablets 3 times a day, in severe forms of the disease, the dose can be doubled to 2-4 tablets 3 times a day.
The duration of the course of treatment is determined by the doctor individually, depending on the nature and course of the disease. The average duration of treatment is 3 months.

Contraindications

Hypersensitivity to the active substance or to other components of the preparation; acute poisoning of various etiologies.

Side effects

The preparation is well tolerated. rarely in some cases and with individual hypersensitivity, the following side effects may occur.
From the nervous system: headache.
On the part of the organ of hearing and labyrinth disorders: strengthening of existing vestibular disorders.
From the digestive tract: digestive disorders, loss of appetite, dyspepsia, heartburn, bloating, flatulence, anorexia, nausea, vomiting, diarrhea.
From the respiratory system, chest and mediastinal organs: shortness of breath.
From the musculoskeletal system: arthralgia.
From the urinary system: increased urine output.
From the immune system: hypersensitivity reactions, including rashes, anaphylactic shock, pruritus, alopecia.
Adverse reactions that occur when using the preparation are transient and disappear after its withdrawal.

Special instructions

Treatment with the preparation for liver disease will be effective if you follow a diet.
If jaundice develops, you should consult your doctor for correction of therapy.
The preparation is used with caution in patients with hormonal disorders (endometriosis, uterine myoma, carcinoma of the breast, ovary and uterus, prostate carcinoma), because of the possible estrogen-like effect of silymarin. In such cases, patients should consult a doctor.
The composition of the preparation includes crystalline sugar, this should be taken into account in patients with diabetes mellitus.
It is necessary to refrain from drinking alcohol during preparation treatment.
The preparation contains lactose, therefore, the preparation should not be used in patients with rare hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption.
Use during pregnancy and lactation. Due to the lack of data on safety and efficacy, the preparation should not be used during pregnancy and lactation.
Children. It is not recommended to use the preparation in children under 12 years of age.
The ability to influence the reaction rate when driving vehicles or other mechanisms. The preparation does not affect the reaction rate when driving vehicles or other mechanisms, however, in the event of any vestibular disorders, one should refrain from driving vehicles or other mechanisms.

Interactions

With the simultaneous use of silymarin with other preparations, the following interactions are possible:
with oral contraceptives, preparations that are used in estrogen replacement therapy - a decrease in the effectiveness of the latter;
with antiallergic preparations (fexofenadine), anticoagulants (clopidogrel, warfarin), antipsychotic preparations (alprazolam, diazepam, lorazepam), hypocholesterolemic preparations (lovastatin), some preparations for the treatment of cancer (vinblastine), antifungal preparations (antifungal preparations) the effectiveness of the latter (due to the inhibition of the cytochrome P450 system with silymarin).
Herbal products containing silymarin are widely used as hepatoprotectors in oncological practice simultaneously with cytostatics. Clinical studies show an insignificant risk of possible pharmacokinetic interactions of silymarin as an inhibitor of the isoenzyme CYP 3A4 and UGT1A1 and cytostatics, which are substrates of these enzymes.

Overdose

Overdose cases have not been identified.
If you accidentally take the preparation in a high dose, you should induce vomiting, rinse the stomach, take activated charcoal and, if necessary, apply symptomatic treatment prescribed by your doctor.

Storage conditions

In its original packaging at a temperature not exceeding 25 ° C.

Tags: Darsil

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