Darsil 22.5mg 50 tablets — Made in Ukraine — Free Delivery

Pharmacodynamics. The active ingredient of the preparation darsil - silymarin - is obtained from the extract of the fruits of the milk thistle plant silybum marianum.

Bioactive components of silymarin neutralize free radicals in the liver, prevent the destruction of cellular structures, in particular, stabilize the membranes of hepatocytes. In damaged hepatocytes, they stimulate the synthesis of structural and functional proteins and phospholipids due to specific stimulation of RNA polymerase, prevent the loss of cell components (transaminases), and accelerate the regeneration of liver cells. They inhibit the penetration of some poisons into hepatocytes, in particular, the poison of the mushroom pale toadstool. They significantly reduce the activity of LPO in the membranes of hepatocytes, thereby contributing to their strengthening.

They improve the general condition in patients with liver diseases, reduce subjective sensations (weakness, a feeling of heaviness in the right hypochondrium). Contributes to the normalization of biochemical parameters of the functional state of the liver (activity of transaminases, γ-glutamylaminotransferase, alkaline phosphatase, bilirubin level).

Pharmacokinetics. After oral administration, silymarin is slowly but not completely absorbed in the digestive tract. Practically does not bind to blood plasma proteins. It is metabolized in the liver by conjugation to form sulfates and glucuronides. It is excreted mainly with bile, in the small intestine it is again absorbed into the systemic circulation, making multiple gradually decaying enterohepatic circulation. T½ is about 6 hours. Virtually does not accumulate in the body.

Toxic liver damage: for the maintenance treatment of patients with chronic inflammatory liver disease or liver cirrhosis.

Darsil tablets are taken orally after meals without chewing, drinking plenty of fluids.

Adults and children over the age of 12 years: in cases of mild and moderate severity, the preparation is used in a dose of 1-2 tablets 3 times a day, in severe forms of the disease, the dose can be doubled to 2-4 tablets 3 times a day.

The duration of the course of treatment is determined by the doctor individually, depending on the nature and course of the disease. The average duration of treatment is 3 months.

Hypersensitivity to the active substance or to other components of the preparation; acute poisoning of various etiologies.

The preparation is well tolerated. rarely in some cases and with individual hypersensitivity, the following side effects may occur.

From the nervous system: headache.

On the part of the organ of hearing and labyrinth disorders: strengthening of existing vestibular disorders.

From the digestive tract: digestive disorders, loss of appetite, dyspepsia, heartburn, bloating, flatulence, anorexia, nausea, vomiting, diarrhea.

From the respiratory system, chest and mediastinal organs: shortness of breath.

From the musculoskeletal system: arthralgia.

From the urinary system: increased urine output.

From the immune system: hypersensitivity reactions, including rashes, anaphylactic shock, pruritus, alopecia.

Adverse reactions that occur when using the preparation are transient and disappear after its withdrawal.

Treatment with the preparation for liver disease will be effective if you follow a diet.

If jaundice develops, you should consult your doctor for correction of therapy.