Dermazin cream 1% 50g — Made in Germany — Free Delivery
(Dermazin )
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Description Dermazin cream 1% 50g — Made in Germany — Free Delivery
Product description
Cream "Dermazin" is used for the following indications:
- prevention of infection and treatment of infected burns, bedsores, ulcers, superficial wounds with weak exudation, abrasions;
- prevention of infection during skin grafting.
Compound
The active substance is silver sulfadiazine (1 g of cream contains silver sulfadiazine 10 mg).
Excipients: cetyl alcohol, hydrogenated peanut oil, polysorbate 60, propylene glycol, methyl paraben (methyl parahydroxybenzoate) (E 218), propyl paraben (propyl parahydroxybenzoate) (E 216), purified water.
Contraindications
- hypersensitivity to silver sulfadiazine, sulfonamides or any other ingredient of the preparation;
- hypersensitivity to peanuts or soy;
- porphyria;
- genetic deficiency of glucose-6-phosphate dehydrogenase (when used on large surfaces, hemolysis may occur);
- purulent and burn wounds with abundant exudation (not advisable);
- premature babies, newborns and children under 3 months (due to the risk of bilirubin encephalopathy).
Mode of application
The preparation is intended for external topical use.
Select the appropriate treatment regimen after assessing the size and depth of the wound surface.
After cleaning the surface of a burn or other wound, apply the cream in a thin layer (2-4 mm) on the damaged surface (or on a sterile gauze napkin, which is applied to the wound surface). The cream is applied with a sterile spatula or a hand in a sterile glove, usually 1 time per day, in severe cases - 2 times per day.
Before each subsequent application of the cream, the burn surface must be washed with 0.9% sodium chloride solution or an antiseptic solution to remove cream residues and wound exudate. You can apply a bandage.
The method of application and dose of the preparation do not depend on the age of the patient. The preparation should be used until the wound is completely healed or until the wound surface is prepared for the appropriate surgical intervention. If the preparation is not used according to the doctor's prescription, it is necessary to contact him for advice if after 7 days of treatment the patient's condition has not improved or worsened.
The cream does not leave stains on clothes and bed linen.
Application features
pregnant
Given the limited experience and risks (sulfonamides, when used systemically, displace bilirubin from binding sites with albumin in blood plasma, which can provoke hyperbilirubinemia and kernicterus in newborns), the preparation should not be used during pregnancy. Silver sulfadiazine should be used with caution in women planning pregnancy.
It is known that sulfonamides increase the risk of bilirubin encephalopathy in newborns, so the use of the cream is contraindicated during breastfeeding.
Children
Due to the risk of nuclear jaundice, silver sulfadiazine should not be used in premature babies, newborns and children under 3 months old.
Since the efficacy and safety of the preparation in children over the age of 3 months have not been determined, it is recommended to prescribe the preparation to patients in this age group after consulting a doctor.
Drivers
There are no data on the adverse effects of the cream on the reaction rate when driving vehicles or operating other mechanisms.
Overdose
Symptoms of intoxication
With an overdose of the cream, side effects associated with the systemic use of all sulfonamides may occur. Long-term use of high doses of silver sulfadiazine may cause an increase in serum silver levels. However, these levels return to normal upon discontinuation of treatment. The phenomenon of overdose may be accompanied by neurological, renal, hepatic, respiratory and hematological manifestations.
In patients with severe burns with prolonged treatment and the use of more than 10 kg of silver sulfadiazine per day, a significant increase in serum osmolarity was observed. The reason for this may be propylene glycol (a component of the cream base of the preparation) and, as a result, improved reabsorption of the preparation in significant burns, affects the skin as a whole.
Treatment of intoxication
In case of overdose, the preparation should be discontinued. Treatment is symptomatic. If necessary, kidney function and blood counts should be monitored. Sulfadiazine, which has been absorbed, is easily excreted by hemo- and peritoneal dialysis.
Side effects
Adverse reactions are given by frequency: very often (≥ 1/10), often (≥ 1/100, < 1/10), infrequently (≥ 1/1000, < 1/100), rarely (≥ 1/10000, < 1 /1000), very rarely (< 1/10000), the frequency is unknown (cannot be calculated from the available data).
On the part of the blood: often - leukopenia, methemoglobinemia, especially in patients with hemoglobin abnormalities, increased serum osmolarity. Transient leukopenia usually does not require discontinuation of therapy or the use of other special measures. Monitoring of the patient's blood counts is recommended.
On the part of the skin and subcutaneous tissue: often - hypersensitivity reactions, irritation and redness of the skin, itching, burning, pain upon application, rash, contact dermatitis, discoloration of the skin to gray under the influence of sunlight (argyria - pigmentation caused by silver deposition), photosensitivity, skin necrosis; very rarely - Stevens-Johnson syndrome, toxic epidermal necrolysis; frequency unknown (cannot be calculated from the available data) - hyperpigmentation, runny nose and asthma of allergic origin, skin discoloration, erythema multiforme.
Storage conditions
Store at a temperature not exceeding 25 ° C, out of the reach of children.
Shelf life - 3 years.
Tags: Dermazin
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